A Case of Mild Encephalopathy with a Reversible Splenial Lesion Associated with G5P[6]Rotavirus Infection
We report a case of mild encephalopathy with a reversible splenial lesion (MERS) associated with acute gastroenteritis caused by rotavirus (RV) infection. The patient (male, 4 years and 3 months old) was admitted to our hospital for diarrhea and afebrile seizures. Head MRI revealed a hyperintense si...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2013/197163 |
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| author | Tsuyoshi Matsuoka Toshifumi Yodoshi Misaki Sugai Masato Hiyane Takashi Matsuoka Hideki Akeda Masaharu Ohfu Satoshi Komoto Koki Taniguchi |
| author_facet | Tsuyoshi Matsuoka Toshifumi Yodoshi Misaki Sugai Masato Hiyane Takashi Matsuoka Hideki Akeda Masaharu Ohfu Satoshi Komoto Koki Taniguchi |
| author_sort | Tsuyoshi Matsuoka |
| collection | DOAJ |
| description | We report a case of mild encephalopathy with a reversible splenial lesion (MERS) associated with acute gastroenteritis caused by rotavirus (RV) infection. The patient (male, 4 years and 3 months old) was admitted to our hospital for diarrhea and afebrile seizures. Head MRI revealed a hyperintense signal in the splenium of the corpus callosum on DWI and a hypointense signal on the ADC-map. After awakening from sedation, the patient's disturbance of consciousness improved. On day 5 after admission of the illness, the patient was discharged from the hospital in a good condition. Electroencephalography on day 2 after admission was normal. On day 8 of admission, head MRI revealed that the splenial lesion had disappeared. RV antigen-positive stools suggested that RV had caused MERS. This RV genotype was considered to be G5P[6]; it may have spread to humans as a strain reassortment through substitution of porcine RV into human RV gene segments. This extremely rare genotype was detected first in Japan and is not covered by existing vaccines; this is the first sample isolated from encephalopathy patients. Few reports have investigated RV genotypes in encephalopathy; we believe that this case is valuable for studying the relationship between genotypes and clinical symptoms. |
| format | Article |
| id | doaj-art-831ac6738f744f4e8f3290f82ca7a2a7 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-831ac6738f744f4e8f3290f82ca7a2a72025-02-03T06:12:43ZengWileyCase Reports in Pediatrics2090-68032090-68112013-01-01201310.1155/2013/197163197163A Case of Mild Encephalopathy with a Reversible Splenial Lesion Associated with G5P[6]Rotavirus InfectionTsuyoshi Matsuoka0Toshifumi Yodoshi1Misaki Sugai2Masato Hiyane3Takashi Matsuoka4Hideki Akeda5Masaharu Ohfu6Satoshi Komoto7Koki Taniguchi8Division of Pediatric Neurology & General, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, JapanDivision of Pediatric Neurology & General, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, JapanDivision of Pediatric Neurology & General, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, JapanDivision of Pediatric Neurology & General, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, JapanDivision of Pediatric Neurology & General, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, JapanDivision of Pediatric Neurology & General, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, JapanDivision of Pediatric Neurology & General, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, JapanDepartment of Virology and Parasitology, Fujita Health University School of Medicine, JapanDepartment of Virology and Parasitology, Fujita Health University School of Medicine, JapanWe report a case of mild encephalopathy with a reversible splenial lesion (MERS) associated with acute gastroenteritis caused by rotavirus (RV) infection. The patient (male, 4 years and 3 months old) was admitted to our hospital for diarrhea and afebrile seizures. Head MRI revealed a hyperintense signal in the splenium of the corpus callosum on DWI and a hypointense signal on the ADC-map. After awakening from sedation, the patient's disturbance of consciousness improved. On day 5 after admission of the illness, the patient was discharged from the hospital in a good condition. Electroencephalography on day 2 after admission was normal. On day 8 of admission, head MRI revealed that the splenial lesion had disappeared. RV antigen-positive stools suggested that RV had caused MERS. This RV genotype was considered to be G5P[6]; it may have spread to humans as a strain reassortment through substitution of porcine RV into human RV gene segments. This extremely rare genotype was detected first in Japan and is not covered by existing vaccines; this is the first sample isolated from encephalopathy patients. Few reports have investigated RV genotypes in encephalopathy; we believe that this case is valuable for studying the relationship between genotypes and clinical symptoms.http://dx.doi.org/10.1155/2013/197163 |
| spellingShingle | Tsuyoshi Matsuoka Toshifumi Yodoshi Misaki Sugai Masato Hiyane Takashi Matsuoka Hideki Akeda Masaharu Ohfu Satoshi Komoto Koki Taniguchi A Case of Mild Encephalopathy with a Reversible Splenial Lesion Associated with G5P[6]Rotavirus Infection Case Reports in Pediatrics |
| title | A Case of Mild Encephalopathy with a Reversible Splenial Lesion Associated with G5P[6]Rotavirus Infection |
| title_full | A Case of Mild Encephalopathy with a Reversible Splenial Lesion Associated with G5P[6]Rotavirus Infection |
| title_fullStr | A Case of Mild Encephalopathy with a Reversible Splenial Lesion Associated with G5P[6]Rotavirus Infection |
| title_full_unstemmed | A Case of Mild Encephalopathy with a Reversible Splenial Lesion Associated with G5P[6]Rotavirus Infection |
| title_short | A Case of Mild Encephalopathy with a Reversible Splenial Lesion Associated with G5P[6]Rotavirus Infection |
| title_sort | case of mild encephalopathy with a reversible splenial lesion associated with g5p 6 rotavirus infection |
| url | http://dx.doi.org/10.1155/2013/197163 |
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