Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds
The diverse pleiotropic pharmacological effects of curcumin nanoformulations have turned it into an attractive natural compound in different health-related problems. A great body of evidence has shown the impact of curcumin and its nanoformulations on the differentiation of stem cells. The current r...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/1520052 |
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| _version_ | 1832556618141663232 |
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| author | Khadijeh Khezri Solmaz Maleki Dizaj Yalda Rahbar Saadat Simin Sharifi Shahriar Shahi Elham Ahmadian Aziz Eftekhari Elaheh Dalir Abdolahinia Farzaneh Lotfipour |
| author_facet | Khadijeh Khezri Solmaz Maleki Dizaj Yalda Rahbar Saadat Simin Sharifi Shahriar Shahi Elham Ahmadian Aziz Eftekhari Elaheh Dalir Abdolahinia Farzaneh Lotfipour |
| author_sort | Khadijeh Khezri |
| collection | DOAJ |
| description | The diverse pleiotropic pharmacological effects of curcumin nanoformulations have turned it into an attractive natural compound in different health-related problems. A great body of evidence has shown the impact of curcumin and its nanoformulations on the differentiation of stem cells. The current review highlights cellular and molecular mechanisms connected with the osteogenic differentiation of mesenchymal stem cells (MSCs) in the scaffolds benefiting from the presence of nanocurcumin pointing toward the role of inhibitory or stimulant signal transduction pathways in detail. Moreover, the effects of different concentrations as well as the structural modifications of curcumin on the differentiation of MSCs have been addressed. |
| format | Article |
| id | doaj-art-8305699c6b084e62a5ee137b42460a1e |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-8305699c6b084e62a5ee137b42460a1e2025-02-03T05:44:51ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/15200521520052Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing NanoscaffoldsKhadijeh Khezri0Solmaz Maleki Dizaj1Yalda Rahbar Saadat2Simin Sharifi3Shahriar Shahi4Elham Ahmadian5Aziz Eftekhari6Elaheh Dalir Abdolahinia7Farzaneh Lotfipour8Deputy of Food and Drug Administration, Urmia University of Medical Sciences, Urmia, IranDental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, IranKidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranDental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, IranDental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, IranKidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranPharmacology and Toxicology Department, Maragheh University of Medical Sciences, Maragheh, IranResearch Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, IranFood and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, IranThe diverse pleiotropic pharmacological effects of curcumin nanoformulations have turned it into an attractive natural compound in different health-related problems. A great body of evidence has shown the impact of curcumin and its nanoformulations on the differentiation of stem cells. The current review highlights cellular and molecular mechanisms connected with the osteogenic differentiation of mesenchymal stem cells (MSCs) in the scaffolds benefiting from the presence of nanocurcumin pointing toward the role of inhibitory or stimulant signal transduction pathways in detail. Moreover, the effects of different concentrations as well as the structural modifications of curcumin on the differentiation of MSCs have been addressed.http://dx.doi.org/10.1155/2021/1520052 |
| spellingShingle | Khadijeh Khezri Solmaz Maleki Dizaj Yalda Rahbar Saadat Simin Sharifi Shahriar Shahi Elham Ahmadian Aziz Eftekhari Elaheh Dalir Abdolahinia Farzaneh Lotfipour Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds Stem Cells International |
| title | Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds |
| title_full | Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds |
| title_fullStr | Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds |
| title_full_unstemmed | Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds |
| title_short | Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds |
| title_sort | osteogenic differentiation of mesenchymal stem cells via curcumin containing nanoscaffolds |
| url | http://dx.doi.org/10.1155/2021/1520052 |
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