Which Are the Cells of Origin in Merkel Cell Carcinoma?
Merkel cell carcinoma (MCC), a highly aggressive skin tumour with increasing incidence, is associated with the newly discovered Merkel cell polyomavirus (MCPyV). Studies on MCC and MCPyV as well as other risk factors have significantly increased our knowledge of MCC pathogenesis, but the cells of or...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/680410 |
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| _version_ | 1832558810531627008 |
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| author | Thomas Tilling Ingrid Moll |
| author_facet | Thomas Tilling Ingrid Moll |
| author_sort | Thomas Tilling |
| collection | DOAJ |
| description | Merkel cell carcinoma (MCC), a highly aggressive skin tumour with increasing incidence, is associated with the newly discovered Merkel cell polyomavirus (MCPyV). Studies on MCC and MCPyV as well as other risk factors have significantly increased our knowledge of MCC pathogenesis, but the cells of origin, which could be important targets in future therapies, are still unknown. Merkel cells (MCs), the neuroendocrine cells of the skin, were believed to be at the origin of MCC due to their phenotypic similarities. However, for several reasons, for example, heterogeneous differentiation of MCCs and postmitotic character of MCs, it is not very likely that MCC develops from differentiated MCs. Skin stem cells, probably from the epidermal lineage, are more likely to be cells of origin in MCC. Future studies will have to address these questions more directly in order to identify the physiological cells which are transformed to MCC cells. |
| format | Article |
| id | doaj-art-82fea11f7e924ad593e5f362ce25ab4b |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-82fea11f7e924ad593e5f362ce25ab4b2025-02-03T01:31:31ZengWileyJournal of Skin Cancer2090-29052090-29132012-01-01201210.1155/2012/680410680410Which Are the Cells of Origin in Merkel Cell Carcinoma?Thomas Tilling0Ingrid Moll1Department of Dermatology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, GermanyDepartment of Dermatology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, GermanyMerkel cell carcinoma (MCC), a highly aggressive skin tumour with increasing incidence, is associated with the newly discovered Merkel cell polyomavirus (MCPyV). Studies on MCC and MCPyV as well as other risk factors have significantly increased our knowledge of MCC pathogenesis, but the cells of origin, which could be important targets in future therapies, are still unknown. Merkel cells (MCs), the neuroendocrine cells of the skin, were believed to be at the origin of MCC due to their phenotypic similarities. However, for several reasons, for example, heterogeneous differentiation of MCCs and postmitotic character of MCs, it is not very likely that MCC develops from differentiated MCs. Skin stem cells, probably from the epidermal lineage, are more likely to be cells of origin in MCC. Future studies will have to address these questions more directly in order to identify the physiological cells which are transformed to MCC cells.http://dx.doi.org/10.1155/2012/680410 |
| spellingShingle | Thomas Tilling Ingrid Moll Which Are the Cells of Origin in Merkel Cell Carcinoma? Journal of Skin Cancer |
| title | Which Are the Cells of Origin in Merkel Cell Carcinoma? |
| title_full | Which Are the Cells of Origin in Merkel Cell Carcinoma? |
| title_fullStr | Which Are the Cells of Origin in Merkel Cell Carcinoma? |
| title_full_unstemmed | Which Are the Cells of Origin in Merkel Cell Carcinoma? |
| title_short | Which Are the Cells of Origin in Merkel Cell Carcinoma? |
| title_sort | which are the cells of origin in merkel cell carcinoma |
| url | http://dx.doi.org/10.1155/2012/680410 |
| work_keys_str_mv | AT thomastilling whicharethecellsoforigininmerkelcellcarcinoma AT ingridmoll whicharethecellsoforigininmerkelcellcarcinoma |