Recent advances in self-targeting natural product-based nanomedicines
Abstract Natural products, recognized for their potential in disease prevention and treatment, have been integrated with advanced nano-delivery systems to create natural product-based nanomedicines, offering innovative approaches for various diseases. Natural products derived from traditional Chines...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03092-9 |
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| author | Haifan Liu Xingyue Jin Suyi Liu Xinyue Liu Xiao Pei Kunhui Sun Meifang Li Ping Wang Yanxu Chang Tiejie Wang Bing Wang Xie-an Yu |
| author_facet | Haifan Liu Xingyue Jin Suyi Liu Xinyue Liu Xiao Pei Kunhui Sun Meifang Li Ping Wang Yanxu Chang Tiejie Wang Bing Wang Xie-an Yu |
| author_sort | Haifan Liu |
| collection | DOAJ |
| description | Abstract Natural products, recognized for their potential in disease prevention and treatment, have been integrated with advanced nano-delivery systems to create natural product-based nanomedicines, offering innovative approaches for various diseases. Natural products derived from traditional Chinese medicine have their own targeting effect and remarkable therapeutic effect on many diseases, but there are some shortcomings such as poor physical and chemical properties. The construction of nanomedicines using the active ingredients of natural products has become a key step in the modernization research process, which could be used to make up for the defects of natural products such as low solubility, large dosage, poor bioavailability and poor targeting. Nanotechnology enhances the safety, selectivity, and efficacy of natural products, positioning natural product-based nanomedicines as promising candidates in medicine. This review outlines the current status of development, the application in different diseases, and safety evaluation of natural product-based nanomedicines, providing essential insights for further exploration of the synergy between natural products and nano-delivery systems in disease treatment. Graphical Abstract |
| format | Article |
| id | doaj-art-82fac53dd1754018b295b36c28203a1e |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-82fac53dd1754018b295b36c28203a1e2025-01-26T12:50:59ZengBMCJournal of Nanobiotechnology1477-31552025-01-0123113010.1186/s12951-025-03092-9Recent advances in self-targeting natural product-based nanomedicinesHaifan Liu0Xingyue Jin1Suyi Liu2Xinyue Liu3Xiao Pei4Kunhui Sun5Meifang Li6Ping Wang7Yanxu Chang8Tiejie Wang9Bing Wang10Xie-an Yu11NMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug ControlNMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug ControlNMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug ControlNMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug ControlNMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug ControlNMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug ControlNMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug ControlNMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug ControlState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese MedicineNMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug ControlNMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug ControlNMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug ControlAbstract Natural products, recognized for their potential in disease prevention and treatment, have been integrated with advanced nano-delivery systems to create natural product-based nanomedicines, offering innovative approaches for various diseases. Natural products derived from traditional Chinese medicine have their own targeting effect and remarkable therapeutic effect on many diseases, but there are some shortcomings such as poor physical and chemical properties. The construction of nanomedicines using the active ingredients of natural products has become a key step in the modernization research process, which could be used to make up for the defects of natural products such as low solubility, large dosage, poor bioavailability and poor targeting. Nanotechnology enhances the safety, selectivity, and efficacy of natural products, positioning natural product-based nanomedicines as promising candidates in medicine. This review outlines the current status of development, the application in different diseases, and safety evaluation of natural product-based nanomedicines, providing essential insights for further exploration of the synergy between natural products and nano-delivery systems in disease treatment. Graphical Abstracthttps://doi.org/10.1186/s12951-025-03092-9Natural productTargetingDelivery systemNanomedicine |
| spellingShingle | Haifan Liu Xingyue Jin Suyi Liu Xinyue Liu Xiao Pei Kunhui Sun Meifang Li Ping Wang Yanxu Chang Tiejie Wang Bing Wang Xie-an Yu Recent advances in self-targeting natural product-based nanomedicines Journal of Nanobiotechnology Natural product Targeting Delivery system Nanomedicine |
| title | Recent advances in self-targeting natural product-based nanomedicines |
| title_full | Recent advances in self-targeting natural product-based nanomedicines |
| title_fullStr | Recent advances in self-targeting natural product-based nanomedicines |
| title_full_unstemmed | Recent advances in self-targeting natural product-based nanomedicines |
| title_short | Recent advances in self-targeting natural product-based nanomedicines |
| title_sort | recent advances in self targeting natural product based nanomedicines |
| topic | Natural product Targeting Delivery system Nanomedicine |
| url | https://doi.org/10.1186/s12951-025-03092-9 |
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