Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-κB Pathway
The aim of this study was to study the protective effect of Huang Qi Tong Bi Decoction (HQTBT) on the heart of rats. Ischemia-reperfusion injury was established by coronary artery ligation. Proinflammatory cytokines were decreased by XFZY in coronary artery ligated rats. ST segment was also restored...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/8387636 |
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| _version_ | 1832552864409452544 |
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| author | Kun Liu Manman Li Xiumei Ren Qing-sheng You Fei Wang Shuo Wang Chun-Hui Ma Wei-Nan Li Qing Ye |
| author_facet | Kun Liu Manman Li Xiumei Ren Qing-sheng You Fei Wang Shuo Wang Chun-Hui Ma Wei-Nan Li Qing Ye |
| author_sort | Kun Liu |
| collection | DOAJ |
| description | The aim of this study was to study the protective effect of Huang Qi Tong Bi Decoction (HQTBT) on the heart of rats. Ischemia-reperfusion injury was established by coronary artery ligation. Proinflammatory cytokines were decreased by XFZY in coronary artery ligated rats. ST segment was also restored with the treatment of HQTBT. Triphenyltetrazole chloride (TTC) staining and pathological analysis showed that HQTBT reduced myocardial injury. Besides, the expressions of HMGB1/TLR/NF-κB pathway in rats were significantly decreased by HQTBT. This study shows that HQTBT inhibited inflammatory reaction on myocardial injury in rats. |
| format | Article |
| id | doaj-art-82e5d6679cb943819bd346d6f34fea3a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-82e5d6679cb943819bd346d6f34fea3a2025-02-03T05:57:37ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/83876368387636Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-κB PathwayKun Liu0Manman Li1Xiumei Ren2Qing-sheng You3Fei Wang4Shuo Wang5Chun-Hui Ma6Wei-Nan Li7Qing Ye8Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, ChinaSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, ChinaDepartment of Traditional Chinese Medicine, Affiliated Hospital of Nantong University, Nantong, ChinaDepartment of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, ChinaDepartment of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, ChinaDepartment of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, ChinaDepartment of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, ChinaDepartment of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, ChinaDepartment of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, ChinaThe aim of this study was to study the protective effect of Huang Qi Tong Bi Decoction (HQTBT) on the heart of rats. Ischemia-reperfusion injury was established by coronary artery ligation. Proinflammatory cytokines were decreased by XFZY in coronary artery ligated rats. ST segment was also restored with the treatment of HQTBT. Triphenyltetrazole chloride (TTC) staining and pathological analysis showed that HQTBT reduced myocardial injury. Besides, the expressions of HMGB1/TLR/NF-κB pathway in rats were significantly decreased by HQTBT. This study shows that HQTBT inhibited inflammatory reaction on myocardial injury in rats.http://dx.doi.org/10.1155/2019/8387636 |
| spellingShingle | Kun Liu Manman Li Xiumei Ren Qing-sheng You Fei Wang Shuo Wang Chun-Hui Ma Wei-Nan Li Qing Ye Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-κB Pathway Mediators of Inflammation |
| title | Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-κB Pathway |
| title_full | Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-κB Pathway |
| title_fullStr | Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-κB Pathway |
| title_full_unstemmed | Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-κB Pathway |
| title_short | Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-κB Pathway |
| title_sort | huang qi tong bi decoction attenuates myocardial ischemia reperfusion injury via hmgb1 tlr nf κb pathway |
| url | http://dx.doi.org/10.1155/2019/8387636 |
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