Induction of Cytoplasmic dsDNA and cGAS-STING Immune Signaling After Exposure of Breast Cancer Cells to X-ray or High-Energetic Carbon Ions

Induction of Cytoplasmic dsDNA and cGAS-STING Immune Signaling After Exposure of Breast Cancer Cells to X-ray or High-Energetic Carbon Ions

Purpose: Radiation therapy can trigger activation of the cyclic GMP-AMP synthase (cGAS)- Stimulator of interferon genes (STING) axis via cytoplasmic dsDNA fragment induction. The activation of cGAS-STING initiates innate immune signaling mediated by interferon type I that can contribute to eradicate...

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Main Authors: Cristina Totis, MSc, Nicole B. Averbeck, PhD, Burkhard Jakob, PhD, Maik Schork, PhD, Gaia Volpi, MSc, Dennis F. Hintze, BSc, Marco Durante, PhD, Claudia Fournier, PhD, Alexander Helm, PhD
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Advances in Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2452109425000703
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