Determination of the effect of danofloxacin on 8-hydroxy-2-deoxyguanosine level
<b>Aim: </b>The primary aim of this study is to determine the effect of danofloxacin administrations on 8-hydroxy-2-deoxyguanosine (8- OHDG) level, oxidative stress biomarker, in sheep. In addition, to determine on heart [Troponin I, creatine kinase-MB (CK-MB) isoenzyme, lactate dehydrog...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1265 |
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| author | Devran Coşkun Rahmi Canbar Yasemin Korkmaz Burak Dik Ayşe Er Enver Yazar |
| author_facet | Devran Coşkun Rahmi Canbar Yasemin Korkmaz Burak Dik Ayşe Er Enver Yazar |
| author_sort | Devran Coşkun |
| collection | DOAJ |
| description | <b>Aim: </b>The primary aim of this study is to determine the effect of
danofloxacin administrations on 8-hydroxy-2-deoxyguanosine (8-
OHDG) level, oxidative stress biomarker, in sheep. In addition, to
determine on heart [Troponin I, creatine kinase-MB (CK-MB) isoenzyme,
lactate dehydrogenase (LDH), aspartate aminotransferase
(AST)], liver [Alkaline phosphatase (ALP), alanine aminotransferase
(ALT)] and kidney [Blood urea nitrogen (BUN), creatinine] damage
biomarkers and hemogram parameters [White blood cell count
(WBC), red blood cell count (RBC), platelet count, hemoglobin, hematocrit].<p>
<b>Materials and Methods:</b> In this study, 6 mg/kg/day (Subcutaneous)
dose of danofloxacin was applied to 10 sheep for 14 days. Blood
samples were taken on day 0 (control), 1, 3, 5, 7, 9, 11, 13 and 15
days. Serum 8-OHDG, troponin I and CK-MB isoenzyme levels were
measured with ELISA reader, while serum LDH, AST, ALT, ALP, creatinine
and BUN values were determined with autoanalyzer. Hemogram
parameters were determined with hemocell counter.<p>
<b>Results:</b> In this study, 8-OHDG levels did not change (P>0,05) statistically,
while temporal elevations in troponin I, CK-MB isoenzyme
and AST levels were determined (P<0,05). Statistical fluctuations
(P<0,05) were determined in BUN levels, while decreases in WBC,
RBC, hemoglobin and hematocrit values (P<0,05) and temporary
increase in platelet level were determined (P<0,05).<p>
<b>Conclusion: </b>It can be stated that danofloxacin administration to
sheep for 14 days does not cause systemic oxidative stress and does
not cause seriously effects to the function of heart, liver, kidney and
bone marrow. |
| format | Article |
| id | doaj-art-82b6c618226947109ec3731026f8a738 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-82b6c618226947109ec3731026f8a7382025-02-03T11:25:38ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19533542242291265Determination of the effect of danofloxacin on 8-hydroxy-2-deoxyguanosine levelDevran Coşkun0Rahmi Canbar1Yasemin Korkmaz2Burak Dik3Ayşe Er4Enver Yazar5Siirt Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Siirt, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, Türkiye<b>Aim: </b>The primary aim of this study is to determine the effect of danofloxacin administrations on 8-hydroxy-2-deoxyguanosine (8- OHDG) level, oxidative stress biomarker, in sheep. In addition, to determine on heart [Troponin I, creatine kinase-MB (CK-MB) isoenzyme, lactate dehydrogenase (LDH), aspartate aminotransferase (AST)], liver [Alkaline phosphatase (ALP), alanine aminotransferase (ALT)] and kidney [Blood urea nitrogen (BUN), creatinine] damage biomarkers and hemogram parameters [White blood cell count (WBC), red blood cell count (RBC), platelet count, hemoglobin, hematocrit].<p> <b>Materials and Methods:</b> In this study, 6 mg/kg/day (Subcutaneous) dose of danofloxacin was applied to 10 sheep for 14 days. Blood samples were taken on day 0 (control), 1, 3, 5, 7, 9, 11, 13 and 15 days. Serum 8-OHDG, troponin I and CK-MB isoenzyme levels were measured with ELISA reader, while serum LDH, AST, ALT, ALP, creatinine and BUN values were determined with autoanalyzer. Hemogram parameters were determined with hemocell counter.<p> <b>Results:</b> In this study, 8-OHDG levels did not change (P>0,05) statistically, while temporal elevations in troponin I, CK-MB isoenzyme and AST levels were determined (P<0,05). Statistical fluctuations (P<0,05) were determined in BUN levels, while decreases in WBC, RBC, hemoglobin and hematocrit values (P<0,05) and temporary increase in platelet level were determined (P<0,05).<p> <b>Conclusion: </b>It can be stated that danofloxacin administration to sheep for 14 days does not cause systemic oxidative stress and does not cause seriously effects to the function of heart, liver, kidney and bone marrow.http://eurasianjvetsci.org/pdf.php3?id=1265danofloxacin8-hydroxy-2-deoxyguanosinesheep |
| spellingShingle | Devran Coşkun Rahmi Canbar Yasemin Korkmaz Burak Dik Ayşe Er Enver Yazar Determination of the effect of danofloxacin on 8-hydroxy-2-deoxyguanosine level Eurasian Journal of Veterinary Sciences danofloxacin 8-hydroxy-2-deoxyguanosine sheep |
| title | Determination of the effect of danofloxacin on 8-hydroxy-2-deoxyguanosine level |
| title_full | Determination of the effect of danofloxacin on 8-hydroxy-2-deoxyguanosine level |
| title_fullStr | Determination of the effect of danofloxacin on 8-hydroxy-2-deoxyguanosine level |
| title_full_unstemmed | Determination of the effect of danofloxacin on 8-hydroxy-2-deoxyguanosine level |
| title_short | Determination of the effect of danofloxacin on 8-hydroxy-2-deoxyguanosine level |
| title_sort | determination of the effect of danofloxacin on 8 hydroxy 2 deoxyguanosine level |
| topic | danofloxacin 8-hydroxy-2-deoxyguanosine sheep |
| url | http://eurasianjvetsci.org/pdf.php3?id=1265 |
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