Synthesis and Antioxidant Activities of Novel 5-Chlorocurcumin, Complemented by Semiempirical Calculations
The novel curcumin derivative (1E,4Z,6E)-5-chloro-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one (5-chlorocurcumin) was prepared from natural curcumin. The newly synthesised compound was characterised by spectral studies (IR, 1H NMR, and 13C NMR). The free radical scavenging activity of 5...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2013/354982 |
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| author | Ahmed A. Al-Amiery Abdul Amir H. Kadhum Hasan R. Obayes Abu Bakar Mohamad |
| author_facet | Ahmed A. Al-Amiery Abdul Amir H. Kadhum Hasan R. Obayes Abu Bakar Mohamad |
| author_sort | Ahmed A. Al-Amiery |
| collection | DOAJ |
| description | The novel curcumin derivative (1E,4Z,6E)-5-chloro-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one (5-chlorocurcumin) was prepared from natural curcumin. The newly synthesised compound was characterised by spectral studies (IR, 1H NMR, and 13C NMR). The free radical scavenging activity of 5-chlorocurcumin has been determined by measuring interaction with the stable free radical DPPH, and 5-chlorocurcumin has shown encouraging antioxidant activities. Theory calculations of the synthesised 5-chlorocurcumin were performed using molecular structures with optimised geometries. Molecular orbital calculations provided a detailed description of the orbitals, including spatial characteristics, nodal patterns, and the contributions of individual atoms. |
| format | Article |
| id | doaj-art-82b3a102751040929013b1ba8e04b948 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-82b3a102751040929013b1ba8e04b9482025-02-03T06:05:20ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2013-01-01201310.1155/2013/354982354982Synthesis and Antioxidant Activities of Novel 5-Chlorocurcumin, Complemented by Semiempirical CalculationsAhmed A. Al-Amiery0Abdul Amir H. Kadhum1Hasan R. Obayes2Abu Bakar Mohamad3Department of Chemical & Process Engineering, Universiti of Kebangsaan Malaysia (UKM), 43000 Bangi, Selangor, MalaysiaDepartment of Chemical & Process Engineering, Universiti of Kebangsaan Malaysia (UKM), 43000 Bangi, Selangor, MalaysiaApplied Chemistry Division, Applied Science Department, University of Technology (UOT), Baghdad 10001, IraqDepartment of Chemical & Process Engineering, Universiti of Kebangsaan Malaysia (UKM), 43000 Bangi, Selangor, MalaysiaThe novel curcumin derivative (1E,4Z,6E)-5-chloro-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one (5-chlorocurcumin) was prepared from natural curcumin. The newly synthesised compound was characterised by spectral studies (IR, 1H NMR, and 13C NMR). The free radical scavenging activity of 5-chlorocurcumin has been determined by measuring interaction with the stable free radical DPPH, and 5-chlorocurcumin has shown encouraging antioxidant activities. Theory calculations of the synthesised 5-chlorocurcumin were performed using molecular structures with optimised geometries. Molecular orbital calculations provided a detailed description of the orbitals, including spatial characteristics, nodal patterns, and the contributions of individual atoms.http://dx.doi.org/10.1155/2013/354982 |
| spellingShingle | Ahmed A. Al-Amiery Abdul Amir H. Kadhum Hasan R. Obayes Abu Bakar Mohamad Synthesis and Antioxidant Activities of Novel 5-Chlorocurcumin, Complemented by Semiempirical Calculations Bioinorganic Chemistry and Applications |
| title | Synthesis and Antioxidant Activities of Novel 5-Chlorocurcumin, Complemented by Semiempirical Calculations |
| title_full | Synthesis and Antioxidant Activities of Novel 5-Chlorocurcumin, Complemented by Semiempirical Calculations |
| title_fullStr | Synthesis and Antioxidant Activities of Novel 5-Chlorocurcumin, Complemented by Semiempirical Calculations |
| title_full_unstemmed | Synthesis and Antioxidant Activities of Novel 5-Chlorocurcumin, Complemented by Semiempirical Calculations |
| title_short | Synthesis and Antioxidant Activities of Novel 5-Chlorocurcumin, Complemented by Semiempirical Calculations |
| title_sort | synthesis and antioxidant activities of novel 5 chlorocurcumin complemented by semiempirical calculations |
| url | http://dx.doi.org/10.1155/2013/354982 |
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