Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components
Gastric cancer is one of the most frequent malignancies in the world. Nonetheless, the knowledge of the molecular events involved in the development of gastric carcinoma is far from complete. One of the hallmarks of gastric cancer is chromosomal instability resulting in abnormal DNA copy number chan...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.1155/2006/650620 |
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| author | Beatriz Carvalho Tineke E. Buffart Rui M. Reis Thomas Mons Cátia Moutinho Paula Silva Nicole C. T. van Grieken Heike Grabsch Cornelis J. H. van de Velde Bauke Ylstra Gerrit A. Meijer Fátima Carneiro |
| author_facet | Beatriz Carvalho Tineke E. Buffart Rui M. Reis Thomas Mons Cátia Moutinho Paula Silva Nicole C. T. van Grieken Heike Grabsch Cornelis J. H. van de Velde Bauke Ylstra Gerrit A. Meijer Fátima Carneiro |
| author_sort | Beatriz Carvalho |
| collection | DOAJ |
| description | Gastric cancer is one of the most frequent malignancies in the world. Nonetheless, the knowledge of the molecular events involved in the development of gastric carcinoma is far from complete. One of the hallmarks of gastric cancer is chromosomal instability resulting in abnormal DNA copy number changes throughout the genome. Mixed gastric carcinomas constitute a rare histological entity, containing the two main histological phenotypes (diffuse and intestinal). Very little is known about the underlying mechanisms of phenotypic divergence in these mixed tumours. To the best of our knowledge only E-Cadherin mutations were implicated so far in the divergence of these tumours and nothing is known about the involvement of chromosome copy number changes in the two divergent histological components. In this study, we compared the DNA copy number changes, in the two different components (diffuse and intestinal) of mixed gastric carcinomas by microarray – comparative genomic hybridisation (array CGH). The analysis of 12 mixed gastric carcinomas showed no significant differences in array CGH profiles between the diffuse and intestinal components of mixed carcinomas. This supports the idea that the phenotypic divergence within mixed gastric carcinomas is not caused by DNA chromosomal aberrations. |
| format | Article |
| id | doaj-art-82ae0c6ad12745e6a256cc707210789f |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-82ae0c6ad12745e6a256cc707210789f2025-02-03T01:09:36ZengWileyCellular Oncology1570-58701875-86062006-01-01285-628329410.1155/2006/650620Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular ComponentsBeatriz Carvalho0Tineke E. Buffart1Rui M. Reis2Thomas Mons3Cátia Moutinho4Paula Silva5Nicole C. T. van Grieken6Heike Grabsch7Cornelis J. H. van de Velde8Bauke Ylstra9Gerrit A. Meijer10Fátima Carneiro11Department of Pathology, VUMC – VU University Medical Centre, The NetherlandsDepartment of Pathology, VUMC – VU University Medical Centre, The NetherlandsLife and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, PortugalDepartment of Pathology, VUMC – VU University Medical Centre, The NetherlandsIPATIMUP – Institute of Molecular Pathology and Immunology, University of Porto, PortugalIPATIMUP – Institute of Molecular Pathology and Immunology, University of Porto, PortugalDepartment of Pathology, VUMC – VU University Medical Centre, The NetherlandsAcademic Unit of Pathology, School of Medicine, University of Leeds, UKDepartment of Surgery, LUMC – Leiden University Medical Centre, The NetherlandsDepartment of Pathology, VUMC – VU University Medical Centre, The NetherlandsDepartment of Pathology, VUMC – VU University Medical Centre, The NetherlandsIPATIMUP – Institute of Molecular Pathology and Immunology, University of Porto, PortugalGastric cancer is one of the most frequent malignancies in the world. Nonetheless, the knowledge of the molecular events involved in the development of gastric carcinoma is far from complete. One of the hallmarks of gastric cancer is chromosomal instability resulting in abnormal DNA copy number changes throughout the genome. Mixed gastric carcinomas constitute a rare histological entity, containing the two main histological phenotypes (diffuse and intestinal). Very little is known about the underlying mechanisms of phenotypic divergence in these mixed tumours. To the best of our knowledge only E-Cadherin mutations were implicated so far in the divergence of these tumours and nothing is known about the involvement of chromosome copy number changes in the two divergent histological components. In this study, we compared the DNA copy number changes, in the two different components (diffuse and intestinal) of mixed gastric carcinomas by microarray – comparative genomic hybridisation (array CGH). The analysis of 12 mixed gastric carcinomas showed no significant differences in array CGH profiles between the diffuse and intestinal components of mixed carcinomas. This supports the idea that the phenotypic divergence within mixed gastric carcinomas is not caused by DNA chromosomal aberrations.http://dx.doi.org/10.1155/2006/650620 |
| spellingShingle | Beatriz Carvalho Tineke E. Buffart Rui M. Reis Thomas Mons Cátia Moutinho Paula Silva Nicole C. T. van Grieken Heike Grabsch Cornelis J. H. van de Velde Bauke Ylstra Gerrit A. Meijer Fátima Carneiro Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components Cellular Oncology |
| title | Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components |
| title_full | Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components |
| title_fullStr | Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components |
| title_full_unstemmed | Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components |
| title_short | Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components |
| title_sort | mixed gastric carcinomas show similar chromosomal aberrations in both their diffuse and glandular components |
| url | http://dx.doi.org/10.1155/2006/650620 |
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