Safety assessment of monosodium glutamate based on intestinal function and flora in mice
Although monosodium glutamate (MSG) is a widely used food additive, its safety and systemic side effects have not been fully clarified. The intestinal flora is closely associated with human health; however, it remains unclear whether MSG consumption can affect health by acting on the intestinal flor...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2022-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000823 |
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| author | Jinzhao Xu Mengqi Tang Yini Liu Jinghan Xu Xiaoxi Xu |
| author_facet | Jinzhao Xu Mengqi Tang Yini Liu Jinghan Xu Xiaoxi Xu |
| author_sort | Jinzhao Xu |
| collection | DOAJ |
| description | Although monosodium glutamate (MSG) is a widely used food additive, its safety and systemic side effects have not been fully clarified. The intestinal flora is closely associated with human health; however, it remains unclear whether MSG consumption can affect health by acting on the intestinal flora. In this study, serum biomarkers, intestinal structure, intestinal immunity, and intestinal flora were examined to investigate the effects of different doses of sodium glutamate on the body, intestinal function, and intestinal flora of mice. The results showed that 30 mg/kg MSG had no significant effect on serum C-reactive protein, trimethylamine N-oxide, angiotensin II, intestinal interleukin (IL)-1β, IL-6, tumor necrosis factor-α, secretory IgA and fecal albumin in mice, but also promoted intestinal development and regulated the intestinal flora. Moreover, 1500 mg/kg MSG increased the risk of cardiovascular disease and damaged the intestinal structure and flora. In this study, MSG was also found to be healthier than salt at the equivalent sodium concentration. Collectively, these findings suggested that low doses of MSG were safe for mice and may have some health benefits as a probiotic by promoting intestinal development and regulating the intestinal flora. |
| format | Article |
| id | doaj-art-82aa21936b514068860ca27f339ae374 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-82aa21936b514068860ca27f339ae3742025-02-03T10:41:39ZengTsinghua University PressFood Science and Human Wellness2213-45302022-01-01111155164Safety assessment of monosodium glutamate based on intestinal function and flora in miceJinzhao Xu0Mengqi Tang1Yini Liu2Jinghan Xu3Xiaoxi Xu4Key Laboratory of Dairy Science, Ministry of Education/College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaKey Laboratory of Dairy Science, Ministry of Education/College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaKey Laboratory of Dairy Science, Ministry of Education/College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaKey Laboratory of Dairy Science, Ministry of Education/College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaCorresponding author at: Key Laboratory of Dairy Science, Ministry of Education/College of Food Science, Northeast Agricultural University, Harbin 150030, China.; Key Laboratory of Dairy Science, Ministry of Education/College of Food Science, Northeast Agricultural University, Harbin 150030, ChinaAlthough monosodium glutamate (MSG) is a widely used food additive, its safety and systemic side effects have not been fully clarified. The intestinal flora is closely associated with human health; however, it remains unclear whether MSG consumption can affect health by acting on the intestinal flora. In this study, serum biomarkers, intestinal structure, intestinal immunity, and intestinal flora were examined to investigate the effects of different doses of sodium glutamate on the body, intestinal function, and intestinal flora of mice. The results showed that 30 mg/kg MSG had no significant effect on serum C-reactive protein, trimethylamine N-oxide, angiotensin II, intestinal interleukin (IL)-1β, IL-6, tumor necrosis factor-α, secretory IgA and fecal albumin in mice, but also promoted intestinal development and regulated the intestinal flora. Moreover, 1500 mg/kg MSG increased the risk of cardiovascular disease and damaged the intestinal structure and flora. In this study, MSG was also found to be healthier than salt at the equivalent sodium concentration. Collectively, these findings suggested that low doses of MSG were safe for mice and may have some health benefits as a probiotic by promoting intestinal development and regulating the intestinal flora.http://www.sciencedirect.com/science/article/pii/S2213453021000823Monosodium glutamateSafety assessmentIntestinal floraIntestinal inflammation |
| spellingShingle | Jinzhao Xu Mengqi Tang Yini Liu Jinghan Xu Xiaoxi Xu Safety assessment of monosodium glutamate based on intestinal function and flora in mice Food Science and Human Wellness Monosodium glutamate Safety assessment Intestinal flora Intestinal inflammation |
| title | Safety assessment of monosodium glutamate based on intestinal function and flora in mice |
| title_full | Safety assessment of monosodium glutamate based on intestinal function and flora in mice |
| title_fullStr | Safety assessment of monosodium glutamate based on intestinal function and flora in mice |
| title_full_unstemmed | Safety assessment of monosodium glutamate based on intestinal function and flora in mice |
| title_short | Safety assessment of monosodium glutamate based on intestinal function and flora in mice |
| title_sort | safety assessment of monosodium glutamate based on intestinal function and flora in mice |
| topic | Monosodium glutamate Safety assessment Intestinal flora Intestinal inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000823 |
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