2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses
Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan parasites with over one million deaths each yea...
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| Language: | English |
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Sciendo
2020-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2020-0031 |
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| author | Serban Georgeta |
| author_facet | Serban Georgeta |
| author_sort | Serban Georgeta |
| collection | DOAJ |
| description | Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan parasites with over one million deaths each year. Due to old medications and drug resistance worldwide, there is an urgent need for new antiparasitic drugs. 1,3,4-Thiadiazoles have been widely studied for medical applications. The chemical, physical and pharmacokinetic properties recommend 1,3,4-thiadiazole ring as a target in drug development. Many scientific papers report the antiparasitic potential of 2-amino-1,3,4-thiadiazoles. This review presents synthetic 2-amino-1,3,4-thiadiazoles exhibiting antitrypanosomal, antimalarial and antitoxoplasmal activities. Although there are insufficient results to state the quality of 2-amino-1,3,4-thiadiazoles as a new class of antiparasitic agents, many reported derivatives can be considered as lead compounds for drug synthesis and a promise for the future treatment of parasitosis and provide a valid strategy for the development of potent antiparasitic drugs. |
| format | Article |
| id | doaj-art-82a471cab658445faa19444b6b0bacc3 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-82a471cab658445faa19444b6b0bacc32025-02-02T15:22:05ZengSciendoActa Pharmaceutica1846-95582020-09-0170325929010.2478/acph-2020-0031acph-2020-00312-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitosesSerban Georgeta0Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy, University of Oradea 410028 Oradea, RomaniaParasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan parasites with over one million deaths each year. Due to old medications and drug resistance worldwide, there is an urgent need for new antiparasitic drugs. 1,3,4-Thiadiazoles have been widely studied for medical applications. The chemical, physical and pharmacokinetic properties recommend 1,3,4-thiadiazole ring as a target in drug development. Many scientific papers report the antiparasitic potential of 2-amino-1,3,4-thiadiazoles. This review presents synthetic 2-amino-1,3,4-thiadiazoles exhibiting antitrypanosomal, antimalarial and antitoxoplasmal activities. Although there are insufficient results to state the quality of 2-amino-1,3,4-thiadiazoles as a new class of antiparasitic agents, many reported derivatives can be considered as lead compounds for drug synthesis and a promise for the future treatment of parasitosis and provide a valid strategy for the development of potent antiparasitic drugs.https://doi.org/10.2478/acph-2020-00312-amino-134-thiadiazolesantiparasitic activityanti-trypanosomal activityantimalarial activityantitoxoplasmal activityinhibitory concentration |
| spellingShingle | Serban Georgeta 2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses Acta Pharmaceutica 2-amino-1 3 4-thiadiazoles antiparasitic activity anti-trypanosomal activity antimalarial activity antitoxoplasmal activity inhibitory concentration |
| title | 2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses |
| title_full | 2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses |
| title_fullStr | 2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses |
| title_full_unstemmed | 2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses |
| title_short | 2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses |
| title_sort | 2 amino 1 3 4 thiadiazoles as prospective agents in trypanosomiasis and other parasitoses |
| topic | 2-amino-1 3 4-thiadiazoles antiparasitic activity anti-trypanosomal activity antimalarial activity antitoxoplasmal activity inhibitory concentration |
| url | https://doi.org/10.2478/acph-2020-0031 |
| work_keys_str_mv | AT serbangeorgeta 2amino134thiadiazolesasprospectiveagentsintrypanosomiasisandotherparasitoses |