The Diagnostic Value of Cystatin C and Mild Hypothermia Therapy Based on Immunoturbidimetry Enhanced by Nanospheres in Asphyxia Neonate
In order to evaluate the early diagnosis value of CysC and the influence of mild hypothermia on the renal damage of asphyxia neonates, the serum cystatin C (CysC) levels of asphyxia neonates and normal neonates were measured by the nanomicrosphere-enhanced immunoturbidimetric method. The treatment w...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/1549795 |
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| author | Xiaoping Dang Xiaojian Hu Yuancui Meng Yan’e Yang Lingfang Zheng Qiong Zhang Nan Dang Jing Hao Liang Zheng Feng Ni |
| author_facet | Xiaoping Dang Xiaojian Hu Yuancui Meng Yan’e Yang Lingfang Zheng Qiong Zhang Nan Dang Jing Hao Liang Zheng Feng Ni |
| author_sort | Xiaoping Dang |
| collection | DOAJ |
| description | In order to evaluate the early diagnosis value of CysC and the influence of mild hypothermia on the renal damage of asphyxia neonates, the serum cystatin C (CysC) levels of asphyxia neonates and normal neonates were measured by the nanomicrosphere-enhanced immunoturbidimetric method. The treatment was carried out, and the influence of mild hypothermia treatment on the renal damage of asphyxia neonates was analyzed. The results showed that the indicators of the asphyxia group were significantly higher than those of the control group, and the severe asphyxia group was significantly higher than that of the mild asphyxia group, which was statistically significant p<0.05; the heart rate of patients in the mild hypothermia treatment group decreased gradually with the decrease in body temperature. And compared with the control group, there was a significant difference (p<0.05); after symptomatic treatment, the two groups of ALT, AST, BUN, and SCR were improved to varying degrees, and the difference was statistically significant compared with before treatment (p<0.05). Studies have shown that serum CysC level can be used as an indicator to detect glomerular filtration function and early asphyxia newborns, and it is sensitive and specific for early diagnosis of kidney damage. At the same time, it can be used to monitor clinical renal function and determine the status of asphyxia newborns. |
| format | Article |
| id | doaj-art-829e299933524096963000de81efef5a |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-829e299933524096963000de81efef5a2025-02-03T05:51:16ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/15497951549795The Diagnostic Value of Cystatin C and Mild Hypothermia Therapy Based on Immunoturbidimetry Enhanced by Nanospheres in Asphyxia NeonateXiaoping Dang0Xiaojian Hu1Yuancui Meng2Yan’e Yang3Lingfang Zheng4Qiong Zhang5Nan Dang6Jing Hao7Liang Zheng8Feng Ni9Department of Neonatal, Second Affiliated Hospital of Xi’an Medical College, Xi’an 710038, ChinaDepartment of Urology, Second Affiliated Hospital of Xi’an Medical College, Xi’an 710038, ChinaDepartment of Neonatal, Second Affiliated Hospital of Xi’an Medical College, Xi’an 710038, ChinaDepartment of Pediatrics, Second Affiliated Hospital of Xi’an Medical College, Xi’an 710038, ChinaDepartment of Neonatal, Second Affiliated Hospital of Xi’an Medical College, Xi’an 710038, ChinaDepartment of Nephrology, Second Affiliated Hospital of Xi’an Medical College, Xi’an 710038, ChinaDepartment of Pharmacy, Second Affiliated Hospital of Xi’an Medical College, Xi’an 710038, ChinaDepartment of Neonatology, Affiliated Hospital of Yan’an University, Yan’an, ChinaDepartment of Urology, Second Affiliated Hospital of Xi’an Medical College, Xi’an 710038, ChinaDepartment of Urology, Second Affiliated Hospital of Xi’an Medical College, Xi’an 710038, ChinaIn order to evaluate the early diagnosis value of CysC and the influence of mild hypothermia on the renal damage of asphyxia neonates, the serum cystatin C (CysC) levels of asphyxia neonates and normal neonates were measured by the nanomicrosphere-enhanced immunoturbidimetric method. The treatment was carried out, and the influence of mild hypothermia treatment on the renal damage of asphyxia neonates was analyzed. The results showed that the indicators of the asphyxia group were significantly higher than those of the control group, and the severe asphyxia group was significantly higher than that of the mild asphyxia group, which was statistically significant p<0.05; the heart rate of patients in the mild hypothermia treatment group decreased gradually with the decrease in body temperature. And compared with the control group, there was a significant difference (p<0.05); after symptomatic treatment, the two groups of ALT, AST, BUN, and SCR were improved to varying degrees, and the difference was statistically significant compared with before treatment (p<0.05). Studies have shown that serum CysC level can be used as an indicator to detect glomerular filtration function and early asphyxia newborns, and it is sensitive and specific for early diagnosis of kidney damage. At the same time, it can be used to monitor clinical renal function and determine the status of asphyxia newborns.http://dx.doi.org/10.1155/2020/1549795 |
| spellingShingle | Xiaoping Dang Xiaojian Hu Yuancui Meng Yan’e Yang Lingfang Zheng Qiong Zhang Nan Dang Jing Hao Liang Zheng Feng Ni The Diagnostic Value of Cystatin C and Mild Hypothermia Therapy Based on Immunoturbidimetry Enhanced by Nanospheres in Asphyxia Neonate Journal of Chemistry |
| title | The Diagnostic Value of Cystatin C and Mild Hypothermia Therapy Based on Immunoturbidimetry Enhanced by Nanospheres in Asphyxia Neonate |
| title_full | The Diagnostic Value of Cystatin C and Mild Hypothermia Therapy Based on Immunoturbidimetry Enhanced by Nanospheres in Asphyxia Neonate |
| title_fullStr | The Diagnostic Value of Cystatin C and Mild Hypothermia Therapy Based on Immunoturbidimetry Enhanced by Nanospheres in Asphyxia Neonate |
| title_full_unstemmed | The Diagnostic Value of Cystatin C and Mild Hypothermia Therapy Based on Immunoturbidimetry Enhanced by Nanospheres in Asphyxia Neonate |
| title_short | The Diagnostic Value of Cystatin C and Mild Hypothermia Therapy Based on Immunoturbidimetry Enhanced by Nanospheres in Asphyxia Neonate |
| title_sort | diagnostic value of cystatin c and mild hypothermia therapy based on immunoturbidimetry enhanced by nanospheres in asphyxia neonate |
| url | http://dx.doi.org/10.1155/2020/1549795 |
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