Sox5 controls the establishment of quiescence in neural stem cells during postnatal development.

Sox5 controls the establishment of quiescence in neural stem cells during postnatal development.

Adult stem cell niches relays in the acquisition of a reversible state of quiescence to ensure long-lasting DNA integrity and cell expansion. Neural stem cells (NSCs) in the dentate gyrus (DG) enter quiescence before the adult hippocampal neurogenic niche is fully established. However, the mechanism...

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Main Authors: Cristina Medina-Menéndez, Paula Tirado-Melendro, Lingling Li, Pilar Rodríguez-Martín, Elena Melgarejo-de la Peña, Mario Díaz-García, María Valdés-Bescós, Rafael López-Sansegundo, Aixa V Morales
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002654
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