Sox5 controls the establishment of quiescence in neural stem cells during postnatal development.
Adult stem cell niches relays in the acquisition of a reversible state of quiescence to ensure long-lasting DNA integrity and cell expansion. Neural stem cells (NSCs) in the dentate gyrus (DG) enter quiescence before the adult hippocampal neurogenic niche is fully established. However, the mechanism...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-07-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3002654 |
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| author | Cristina Medina-Menéndez Paula Tirado-Melendro Lingling Li Pilar Rodríguez-Martín Elena Melgarejo-de la Peña Mario Díaz-García María Valdés-Bescós Rafael López-Sansegundo Aixa V Morales |
| author_facet | Cristina Medina-Menéndez Paula Tirado-Melendro Lingling Li Pilar Rodríguez-Martín Elena Melgarejo-de la Peña Mario Díaz-García María Valdés-Bescós Rafael López-Sansegundo Aixa V Morales |
| author_sort | Cristina Medina-Menéndez |
| collection | DOAJ |
| description | Adult stem cell niches relays in the acquisition of a reversible state of quiescence to ensure long-lasting DNA integrity and cell expansion. Neural stem cells (NSCs) in the dentate gyrus (DG) enter quiescence before the adult hippocampal neurogenic niche is fully established. However, the mechanisms controlling NSC first quiescence entry and quiescence deepness are largely unknown. Using conditional mutant mouse during embryonic or postnatal stages, we have determined that transcription factor Sox5 is required to restrict first entry in quiescence. Moreover, we have found a critical window during the second postnatal week when NSCs build up a shallow quiescent state. Loss of Sox5 leads to an excess of NSCs in shallow quiescence, which are prone to activate, leading to a neurogenic burst in the adult DG and precocious depletion of the NSC pool. Mechanistically, Sox5 prevents an excess of BMP canonical signaling, a pathway that is required to maintain the correct levels of NSC quiescence during the second postnatal week. In conclusion, our results demonstrate that Sox5 is required to control the correct balance between shallow and deep quiescence during the first postnatal weeks of DG development, a balance which is essential for establishing long-lasting adult neurogenesis. |
| format | Article |
| id | doaj-art-829be9e76adb438cbe956ec00a06d124 |
| institution | Kabale University |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-829be9e76adb438cbe956ec00a06d1242025-08-20T03:40:46ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852025-07-01237e300265410.1371/journal.pbio.3002654Sox5 controls the establishment of quiescence in neural stem cells during postnatal development.Cristina Medina-MenéndezPaula Tirado-MelendroLingling LiPilar Rodríguez-MartínElena Melgarejo-de la PeñaMario Díaz-GarcíaMaría Valdés-BescósRafael López-SansegundoAixa V MoralesAdult stem cell niches relays in the acquisition of a reversible state of quiescence to ensure long-lasting DNA integrity and cell expansion. Neural stem cells (NSCs) in the dentate gyrus (DG) enter quiescence before the adult hippocampal neurogenic niche is fully established. However, the mechanisms controlling NSC first quiescence entry and quiescence deepness are largely unknown. Using conditional mutant mouse during embryonic or postnatal stages, we have determined that transcription factor Sox5 is required to restrict first entry in quiescence. Moreover, we have found a critical window during the second postnatal week when NSCs build up a shallow quiescent state. Loss of Sox5 leads to an excess of NSCs in shallow quiescence, which are prone to activate, leading to a neurogenic burst in the adult DG and precocious depletion of the NSC pool. Mechanistically, Sox5 prevents an excess of BMP canonical signaling, a pathway that is required to maintain the correct levels of NSC quiescence during the second postnatal week. In conclusion, our results demonstrate that Sox5 is required to control the correct balance between shallow and deep quiescence during the first postnatal weeks of DG development, a balance which is essential for establishing long-lasting adult neurogenesis.https://doi.org/10.1371/journal.pbio.3002654 |
| spellingShingle | Cristina Medina-Menéndez Paula Tirado-Melendro Lingling Li Pilar Rodríguez-Martín Elena Melgarejo-de la Peña Mario Díaz-García María Valdés-Bescós Rafael López-Sansegundo Aixa V Morales Sox5 controls the establishment of quiescence in neural stem cells during postnatal development. PLoS Biology |
| title | Sox5 controls the establishment of quiescence in neural stem cells during postnatal development. |
| title_full | Sox5 controls the establishment of quiescence in neural stem cells during postnatal development. |
| title_fullStr | Sox5 controls the establishment of quiescence in neural stem cells during postnatal development. |
| title_full_unstemmed | Sox5 controls the establishment of quiescence in neural stem cells during postnatal development. |
| title_short | Sox5 controls the establishment of quiescence in neural stem cells during postnatal development. |
| title_sort | sox5 controls the establishment of quiescence in neural stem cells during postnatal development |
| url | https://doi.org/10.1371/journal.pbio.3002654 |
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