A method for analyzing the stability of the resting state for a model ofpacemaker cells surrounded by stable cells
The purpose of this paper is to derive and analyze methods for examining the stability of solutions of partial differential equations modeling collections of excitable cells. In particular, we derive methods for estimating the principal eigenvalue of a linearized version of the Luo-Rudy I model clos...
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| Format: | Article |
| Language: | English |
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AIMS Press
2010-05-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2010.7.505 |
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| author | Robert Artebrant Aslak Tveito Glenn T. Lines |
| author_facet | Robert Artebrant Aslak Tveito Glenn T. Lines |
| author_sort | Robert Artebrant |
| collection | DOAJ |
| description | The purpose of this paper is to derive and analyze methods for examining the stability of solutions of partial differential equations modeling collections of excitable cells. In particular, we derive methods for estimating the principal eigenvalue of a linearized version of the Luo-Rudy I model close to an equilibrium solution. It has been suggested that the stability of a collection of unstable cells surrounded by a large collection of stable cells can be studied by considering only a collection of unstable cells equipped with a Dirichlet type boundary condition. This method has earlier been applied to analytically assess the stability of a reduced version the Luo-Rudy I model. In this paper we analyze the accuracy of this technique and apply it to the full Luo-Rudy I model. Furthermore, we extend the method to provide analytical results for the FitzHugh-Nagumo model in the case where a collection of unstable cells is surrounded by a collection of stable cells. All our analytical findings are complemented by numerical computations computing the principal eigenvalue of a discrete version of linearized models. |
| format | Article |
| id | doaj-art-828bd7018d8a4627992e513fa36b41ea |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2010-05-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-828bd7018d8a4627992e513fa36b41ea2025-01-24T02:00:43ZengAIMS PressMathematical Biosciences and Engineering1551-00182010-05-017350552610.3934/mbe.2010.7.505A method for analyzing the stability of the resting state for a model ofpacemaker cells surrounded by stable cellsRobert Artebrant0Aslak Tveito1Glenn T. Lines2Simula Research Laboratory, P.O. Box 134, 1325 LysakerSimula Research Laboratory, P.O. Box 134, 1325 LysakerSimula Research Laboratory, P.O. Box 134, 1325 LysakerThe purpose of this paper is to derive and analyze methods for examining the stability of solutions of partial differential equations modeling collections of excitable cells. In particular, we derive methods for estimating the principal eigenvalue of a linearized version of the Luo-Rudy I model close to an equilibrium solution. It has been suggested that the stability of a collection of unstable cells surrounded by a large collection of stable cells can be studied by considering only a collection of unstable cells equipped with a Dirichlet type boundary condition. This method has earlier been applied to analytically assess the stability of a reduced version the Luo-Rudy I model. In this paper we analyze the accuracy of this technique and apply it to the full Luo-Rudy I model. Furthermore, we extend the method to provide analytical results for the FitzHugh-Nagumo model in the case where a collection of unstable cells is surrounded by a collection of stable cells. All our analytical findings are complemented by numerical computations computing the principal eigenvalue of a discrete version of linearized models.https://www.aimspress.com/article/doi/10.3934/mbe.2010.7.505ectopic wavespartial differential equationsstability. |
| spellingShingle | Robert Artebrant Aslak Tveito Glenn T. Lines A method for analyzing the stability of the resting state for a model ofpacemaker cells surrounded by stable cells Mathematical Biosciences and Engineering ectopic waves partial differential equations stability. |
| title | A method for analyzing the stability of the resting state for a model ofpacemaker cells surrounded by stable cells |
| title_full | A method for analyzing the stability of the resting state for a model ofpacemaker cells surrounded by stable cells |
| title_fullStr | A method for analyzing the stability of the resting state for a model ofpacemaker cells surrounded by stable cells |
| title_full_unstemmed | A method for analyzing the stability of the resting state for a model ofpacemaker cells surrounded by stable cells |
| title_short | A method for analyzing the stability of the resting state for a model ofpacemaker cells surrounded by stable cells |
| title_sort | method for analyzing the stability of the resting state for a model ofpacemaker cells surrounded by stable cells |
| topic | ectopic waves partial differential equations stability. |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2010.7.505 |
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