Thermodynamic and Structural Characterization of a Mechanochemically Synthesized Pyrazinamide–Acetylsalicylic–Acid Eutectic Mixture

Thermodynamic and Structural Characterization of a Mechanochemically Synthesized Pyrazinamide–Acetylsalicylic–Acid Eutectic Mixture

<b>Background/Objectives:</b> This study aims to develop a sustainable and environmentally friendly drug delivery system by synthesizing a novel drug–drug eutectic mixture (DDEM) of acetylsalicylic acid (ASA) and pyrazinamide (PZA) using a green and efficient mechanochemical approach. &l...

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Bibliographic Details
Main Authors: Luís H. S. Queiroz, Mateus R. Lage, Clenilton C. dos Santos, Mafalda C. Sarraguça, Paulo R. S. Ribeiro
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceuticals
Subjects:
acetylsalicylic acid (ASA)
pyrazinamide (PZA)
drug–drug eutectic mixture (DDEM)
DFT calculations
green chemistry
mechanochemistry
Online Access:https://www.mdpi.com/1424-8247/18/2/211
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