RNA Viruses: ROS-Mediated Cell Death
Reactive oxygen species (ROS) are well known for being both beneficial and deleterious. The main thrust of this review is to investigate the role of ROS in ribonucleic acid (RNA) virus pathogenesis. Much evidences has accumulated over the past decade, suggesting that patients infected with RNA virus...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2014/467452 |
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| _version_ | 1832549110519955456 |
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| author | Mohammad Latif Reshi Yi-Che Su Jiann-Ruey Hong |
| author_facet | Mohammad Latif Reshi Yi-Che Su Jiann-Ruey Hong |
| author_sort | Mohammad Latif Reshi |
| collection | DOAJ |
| description | Reactive oxygen species (ROS) are well known for being both beneficial and deleterious. The main thrust of this review is to investigate the role of ROS in ribonucleic acid (RNA) virus pathogenesis. Much evidences has accumulated over the past decade, suggesting that patients infected with RNA viruses are under chronic oxidative stress. Changes to the body’s antioxidant defense system, in relation to SOD, ascorbic acid, selenium, carotenoids, and glutathione, have been reported in various tissues of RNA-virus infected patients. This review focuses on RNA viruses and retroviruses, giving particular attention to the human influenza virus, Hepatitis c virus (HCV), human immunodeficiency virus (HIV), and the aquatic Betanodavirus. Oxidative stress via RNA virus infections can contribute to several aspects of viral disease pathogenesis including apoptosis, loss of immune function, viral replication, inflammatory response, and loss of body weight. We focus on how ROS production is correlated with host cell death. Moreover, ROS may play an important role as a signal molecule in the regulation of viral replication and organelle function, potentially providing new insights in the prevention and treatment of RNA viruses and retrovirus infections. |
| format | Article |
| id | doaj-art-828ac9de2ee54f7da3d29b8b8258c5bb |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-828ac9de2ee54f7da3d29b8b8258c5bb2025-02-03T06:12:10ZengWileyInternational Journal of Cell Biology1687-88761687-88842014-01-01201410.1155/2014/467452467452RNA Viruses: ROS-Mediated Cell DeathMohammad Latif Reshi0Yi-Che Su1Jiann-Ruey Hong2Laboratory of Molecular Virology and Biotechnology, Institute of Biotechnology, National Cheng Kung University, Tainan 701, TaiwanLaboratory of Molecular Virology and Biotechnology, Institute of Biotechnology, National Cheng Kung University, Tainan 701, TaiwanLaboratory of Molecular Virology and Biotechnology, Institute of Biotechnology, National Cheng Kung University, Tainan 701, TaiwanReactive oxygen species (ROS) are well known for being both beneficial and deleterious. The main thrust of this review is to investigate the role of ROS in ribonucleic acid (RNA) virus pathogenesis. Much evidences has accumulated over the past decade, suggesting that patients infected with RNA viruses are under chronic oxidative stress. Changes to the body’s antioxidant defense system, in relation to SOD, ascorbic acid, selenium, carotenoids, and glutathione, have been reported in various tissues of RNA-virus infected patients. This review focuses on RNA viruses and retroviruses, giving particular attention to the human influenza virus, Hepatitis c virus (HCV), human immunodeficiency virus (HIV), and the aquatic Betanodavirus. Oxidative stress via RNA virus infections can contribute to several aspects of viral disease pathogenesis including apoptosis, loss of immune function, viral replication, inflammatory response, and loss of body weight. We focus on how ROS production is correlated with host cell death. Moreover, ROS may play an important role as a signal molecule in the regulation of viral replication and organelle function, potentially providing new insights in the prevention and treatment of RNA viruses and retrovirus infections.http://dx.doi.org/10.1155/2014/467452 |
| spellingShingle | Mohammad Latif Reshi Yi-Che Su Jiann-Ruey Hong RNA Viruses: ROS-Mediated Cell Death International Journal of Cell Biology |
| title | RNA Viruses: ROS-Mediated Cell Death |
| title_full | RNA Viruses: ROS-Mediated Cell Death |
| title_fullStr | RNA Viruses: ROS-Mediated Cell Death |
| title_full_unstemmed | RNA Viruses: ROS-Mediated Cell Death |
| title_short | RNA Viruses: ROS-Mediated Cell Death |
| title_sort | rna viruses ros mediated cell death |
| url | http://dx.doi.org/10.1155/2014/467452 |
| work_keys_str_mv | AT mohammadlatifreshi rnavirusesrosmediatedcelldeath AT yichesu rnavirusesrosmediatedcelldeath AT jiannrueyhong rnavirusesrosmediatedcelldeath |