Changes in DNA methylation are associated with systemic lupus erythematosus flare remission and clinical subtypes

Changes in DNA methylation are associated with systemic lupus erythematosus flare remission and clinical subtypes

Abstract Background Systemic lupus erythematosus (SLE) has numerous symptoms across organs and an unpredictable flare-remittance pattern. This has made it challenging to understand drivers of long-term SLE outcomes. Our objective was to identify whether changes in DNA methylation over time, in an ac...

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Bibliographic Details
Main Authors: Mary K. Horton, Joanne Nititham, Kimberly E. Taylor, Patricia Katz, Chun Jimmie Ye, Jinoos Yazdany, Maria Dall’Era, Charlotte Hurabielle, Lisa F. Barcellos, Lindsey A. Criswell, Cristina M. Lanata
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
Disease subtyping
Systemic lupus erythematosus
Unsupervised machine learning
Hierarchical clustering
Longitudinal
Online Access:https://doi.org/10.1186/s13148-024-01792-x
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