Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives
Cholesterol is one of the most vital compounds for animals as it is involved in various biological processes and acts as the structural material in the body. However, insects do not have some of the essential enzymes in the cholesterol biosynthesis pathway and this makes them dependent on dietary ch...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2019/7240356 |
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| author | Hirunika Perera Tharaka Wijerathna |
| author_facet | Hirunika Perera Tharaka Wijerathna |
| author_sort | Hirunika Perera |
| collection | DOAJ |
| description | Cholesterol is one of the most vital compounds for animals as it is involved in various biological processes and acts as the structural material in the body. However, insects do not have some of the essential enzymes in the cholesterol biosynthesis pathway and this makes them dependent on dietary cholesterol. Thus, the blocking of cholesterol uptake may have detrimental effects on the survival of the insect. Utilizing this character, certain phytochemicals can be used to inhibit mosquito sterol carrier protein-2 (AeSCP-2) activity via competitive binding and proven to have effective insecticidal activities against disease-transmitting mosquitoes and other insect vectors. A range of synthetic compounds, phytochemicals, and synthetic analogs of phytochemicals are found to have AeSCP-2 inhibitory activity. Phytochemicals such as alpha-mangostin can be considered as the most promising group of compounds when considering the minimum environmental impact and availability at a low cost. Once the few limitations such as very low persistence in the environment are addressed successfully, these chemicals may be used as an effective tool for controlling mosquitoes and other disease-transmitting vector populations. |
| format | Article |
| id | doaj-art-828719d8dcfe4f40a267fbbacd9a170f |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-828719d8dcfe4f40a267fbbacd9a170f2025-02-03T06:05:48ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932019-01-01201910.1155/2019/72403567240356Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future PerspectivesHirunika Perera0Tharaka Wijerathna1Department of Parasitology, Faculty of Medicine, University of Kelaniya, Colombo, Sri LankaDepartment of Parasitology, Faculty of Medicine, University of Kelaniya, Colombo, Sri LankaCholesterol is one of the most vital compounds for animals as it is involved in various biological processes and acts as the structural material in the body. However, insects do not have some of the essential enzymes in the cholesterol biosynthesis pathway and this makes them dependent on dietary cholesterol. Thus, the blocking of cholesterol uptake may have detrimental effects on the survival of the insect. Utilizing this character, certain phytochemicals can be used to inhibit mosquito sterol carrier protein-2 (AeSCP-2) activity via competitive binding and proven to have effective insecticidal activities against disease-transmitting mosquitoes and other insect vectors. A range of synthetic compounds, phytochemicals, and synthetic analogs of phytochemicals are found to have AeSCP-2 inhibitory activity. Phytochemicals such as alpha-mangostin can be considered as the most promising group of compounds when considering the minimum environmental impact and availability at a low cost. Once the few limitations such as very low persistence in the environment are addressed successfully, these chemicals may be used as an effective tool for controlling mosquitoes and other disease-transmitting vector populations.http://dx.doi.org/10.1155/2019/7240356 |
| spellingShingle | Hirunika Perera Tharaka Wijerathna Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives |
| title_full | Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives |
| title_fullStr | Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives |
| title_full_unstemmed | Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives |
| title_short | Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives |
| title_sort | sterol carrier protein inhibition based control of mosquito vectors current knowledge and future perspectives |
| url | http://dx.doi.org/10.1155/2019/7240356 |
| work_keys_str_mv | AT hirunikaperera sterolcarrierproteininhibitionbasedcontrolofmosquitovectorscurrentknowledgeandfutureperspectives AT tharakawijerathna sterolcarrierproteininhibitionbasedcontrolofmosquitovectorscurrentknowledgeandfutureperspectives |