Safety and efficacy of remifentanil in patients undergoing bariatric and metabolic surgeries – A systematic review
Background and Aims: Obese patients undergoing bariatric and metabolic surgeries have a high chance of respiratory depression and could need admission to an intensive care unit or a high-dependency unit. Several studies have compared remifentanil to other opioids or non-opioids in these patients. Th...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Anaesthesia |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ija.ija_825_24 |
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| author | Abhijit S. Nair Indira Gurajala Nitinkumar Borkar Ujjwalraj Dudhedia Manamohan Rangaiah Sandeep Diwan |
| author_facet | Abhijit S. Nair Indira Gurajala Nitinkumar Borkar Ujjwalraj Dudhedia Manamohan Rangaiah Sandeep Diwan |
| author_sort | Abhijit S. Nair |
| collection | DOAJ |
| description | Background and Aims:
Obese patients undergoing bariatric and metabolic surgeries have a high chance of respiratory depression and could need admission to an intensive care unit or a high-dependency unit. Several studies have compared remifentanil to other opioids or non-opioids in these patients. This review investigated the efficacy and safety of remifentanil in bariatric and metabolic surgeries.
Methods:
After registering with PROSPERO, we searched PubMed/Medline, Ovid, CINAHL and the Cochrane Library with relevant keywords to find studies in which remifentanil was compared to other opioids or non-opioids in adult patients undergoing bariatric and metabolic surgeries. We used the risk of bias-2 tool to assess bias and Grading of Recommendation, Assessment, Development and Evaluation to determine the level of evidence. RevMan 5.4 was used to perform a quantitative meta-analysis.
Results:
Of the 121 articles retrieved from the database search, seven articles fulfilled the inclusion criteria. The overall bias was low in five studies and high in two studies. There was significant heterogeneity in the control group, which comprised opioids and also non-opioids like labetalol, dexmedetomidine and lignocaine. A quantitative meta-analysis was not reported due to a lack of comparable data for a meaningful quantitative meta-analysis.
Conclusion:
The results of this systematic review neither support nor refute the use of remifentanil in patients undergoing bariatric and metabolic surgeries, compared to other medications. Further studies are needed to investigate its efficacy and safety in these patients. |
| format | Article |
| id | doaj-art-8284477038b9490fbf93fe8a87b17274 |
| institution | Kabale University |
| issn | 0019-5049 0976-2817 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Anaesthesia |
| spelling | doaj-art-8284477038b9490fbf93fe8a87b172742025-02-06T05:26:09ZengWolters Kluwer Medknow PublicationsIndian Journal of Anaesthesia0019-50490976-28172025-01-0169112313110.4103/ija.ija_825_24Safety and efficacy of remifentanil in patients undergoing bariatric and metabolic surgeries – A systematic reviewAbhijit S. NairIndira GurajalaNitinkumar BorkarUjjwalraj DudhediaManamohan RangaiahSandeep DiwanBackground and Aims: Obese patients undergoing bariatric and metabolic surgeries have a high chance of respiratory depression and could need admission to an intensive care unit or a high-dependency unit. Several studies have compared remifentanil to other opioids or non-opioids in these patients. This review investigated the efficacy and safety of remifentanil in bariatric and metabolic surgeries. Methods: After registering with PROSPERO, we searched PubMed/Medline, Ovid, CINAHL and the Cochrane Library with relevant keywords to find studies in which remifentanil was compared to other opioids or non-opioids in adult patients undergoing bariatric and metabolic surgeries. We used the risk of bias-2 tool to assess bias and Grading of Recommendation, Assessment, Development and Evaluation to determine the level of evidence. RevMan 5.4 was used to perform a quantitative meta-analysis. Results: Of the 121 articles retrieved from the database search, seven articles fulfilled the inclusion criteria. The overall bias was low in five studies and high in two studies. There was significant heterogeneity in the control group, which comprised opioids and also non-opioids like labetalol, dexmedetomidine and lignocaine. A quantitative meta-analysis was not reported due to a lack of comparable data for a meaningful quantitative meta-analysis. Conclusion: The results of this systematic review neither support nor refute the use of remifentanil in patients undergoing bariatric and metabolic surgeries, compared to other medications. Further studies are needed to investigate its efficacy and safety in these patients.https://journals.lww.com/10.4103/ija.ija_825_24acute painanaesthesiabariatric surgerymeta-analysismetabolic surgeryopioidsremifentanilsystematic review |
| spellingShingle | Abhijit S. Nair Indira Gurajala Nitinkumar Borkar Ujjwalraj Dudhedia Manamohan Rangaiah Sandeep Diwan Safety and efficacy of remifentanil in patients undergoing bariatric and metabolic surgeries – A systematic review Indian Journal of Anaesthesia acute pain anaesthesia bariatric surgery meta-analysis metabolic surgery opioids remifentanil systematic review |
| title | Safety and efficacy of remifentanil in patients undergoing bariatric and metabolic surgeries – A systematic review |
| title_full | Safety and efficacy of remifentanil in patients undergoing bariatric and metabolic surgeries – A systematic review |
| title_fullStr | Safety and efficacy of remifentanil in patients undergoing bariatric and metabolic surgeries – A systematic review |
| title_full_unstemmed | Safety and efficacy of remifentanil in patients undergoing bariatric and metabolic surgeries – A systematic review |
| title_short | Safety and efficacy of remifentanil in patients undergoing bariatric and metabolic surgeries – A systematic review |
| title_sort | safety and efficacy of remifentanil in patients undergoing bariatric and metabolic surgeries a systematic review |
| topic | acute pain anaesthesia bariatric surgery meta-analysis metabolic surgery opioids remifentanil systematic review |
| url | https://journals.lww.com/10.4103/ija.ija_825_24 |
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