Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish
We report analysis of the ocular lens phenotype of the recessive, larval lethal zebrafish mutant, lama1a69/a69. Previous work revealed that this mutant has a shortened body axis and eye defects including a defective hyaloid vasculature, focal corneal dysplasia, and loss of the crystalline lens. Whil...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/524929 |
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| author | Mallika Pathania Elena V. Semina Melinda K. Duncan |
| author_facet | Mallika Pathania Elena V. Semina Melinda K. Duncan |
| author_sort | Mallika Pathania |
| collection | DOAJ |
| description | We report analysis of the ocular lens phenotype of the recessive, larval lethal zebrafish mutant, lama1a69/a69. Previous work revealed that this mutant has a shortened body axis and eye defects including a defective hyaloid vasculature, focal corneal dysplasia, and loss of the crystalline lens. While these studies highlight the importance of laminin α1 in lens development, a detailed analysis of the lens defects seen in these mutants was not reported. In the present study, we analyze the lenticular anomalies seen in the lama1a69/a69 mutants and show that the lens defects result from the anterior extrusion of lens material from the eye secondary to structural defects in the lens capsule and developing corneal epithelium associated with basement membrane loss. Our analysis provides further insights into the role of the lens capsule and corneal basement membrane in the structural integrity of the developing eye. |
| format | Article |
| id | doaj-art-82816399e4d04bdfa37027a2106d93fa |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-82816399e4d04bdfa37027a2106d93fa2025-02-03T01:02:25ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/524929524929Lens Extrusion from Laminin Alpha 1 Mutant ZebrafishMallika Pathania0Elena V. Semina1Melinda K. Duncan2Department of Biological Sciences, University of Delaware, 327 Wolf Hall Newark, DE 19716, USADepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Biological Sciences, University of Delaware, 327 Wolf Hall Newark, DE 19716, USAWe report analysis of the ocular lens phenotype of the recessive, larval lethal zebrafish mutant, lama1a69/a69. Previous work revealed that this mutant has a shortened body axis and eye defects including a defective hyaloid vasculature, focal corneal dysplasia, and loss of the crystalline lens. While these studies highlight the importance of laminin α1 in lens development, a detailed analysis of the lens defects seen in these mutants was not reported. In the present study, we analyze the lenticular anomalies seen in the lama1a69/a69 mutants and show that the lens defects result from the anterior extrusion of lens material from the eye secondary to structural defects in the lens capsule and developing corneal epithelium associated with basement membrane loss. Our analysis provides further insights into the role of the lens capsule and corneal basement membrane in the structural integrity of the developing eye.http://dx.doi.org/10.1155/2014/524929 |
| spellingShingle | Mallika Pathania Elena V. Semina Melinda K. Duncan Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish The Scientific World Journal |
| title | Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish |
| title_full | Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish |
| title_fullStr | Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish |
| title_full_unstemmed | Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish |
| title_short | Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish |
| title_sort | lens extrusion from laminin alpha 1 mutant zebrafish |
| url | http://dx.doi.org/10.1155/2014/524929 |
| work_keys_str_mv | AT mallikapathania lensextrusionfromlamininalpha1mutantzebrafish AT elenavsemina lensextrusionfromlamininalpha1mutantzebrafish AT melindakduncan lensextrusionfromlamininalpha1mutantzebrafish |