Short Telomere Length in Plasma of Sudanese Patients with Hepatocellular Carcinoma and Chronic Liver Diseases
Background: Telomeres, a protective sequence of DNA at the end of chromosomes, are essential for the maintenance of chromosomal integrity and stability. With each cell division, telomeres are shortened until a critical length is reached. Several cancers have been linked to shortened telomere length...
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| Format: | Article |
| Language: | English |
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Knowledge E
2024-12-01
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| Series: | Sudan Journal of Medical Sciences |
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| Online Access: | https://knepublishing.com/index.php/SJMS/article/view/16404 |
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| author | Fayza A. Rahamtalla Iman M. Shammat Salma B. M. Mudawi Maram Abbas Mohammed A. H. Kheir Elsid Mohammed S. M. Abdalla |
| author_facet | Fayza A. Rahamtalla Iman M. Shammat Salma B. M. Mudawi Maram Abbas Mohammed A. H. Kheir Elsid Mohammed S. M. Abdalla |
| author_sort | Fayza A. Rahamtalla |
| collection | DOAJ |
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Background: Telomeres, a protective sequence of DNA at the end of chromosomes, are essential for the maintenance of chromosomal integrity and stability. With each cell division, telomeres are shortened until a critical length is reached. Several cancers have been linked to shortened telomere length (TL). The current cross-sectional study aims to investigate the TL in the plasma of Sudanese patients with hepatocellular carcinoma (HCC) and chronic liver diseases (CLD).
Methods: Blood samples were obtained from 113 patients with HCC and CLD as well as from 50 healthy controls. The assessment of TL in blood samples was carried out using the relative quantitative PCR method.
Results: Patients with HCC had significantly shorter TL than healthy controls (0.66 vs 0.89; P < 0.01), whereas insignificant shorter TL was detected in HCC patients as compared to those with CLD. A significant decrease in telomeres copy numbers was observed in HCC patients when compared to those with CLD (P < 0.01).
Conclusion: The results of the present study demonstrate that TL is shorter in patients with HCC and CLD compared to healthy controls.
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| format | Article |
| id | doaj-art-8276c9b61b7f41a39cab22692ab8be4c |
| institution | Kabale University |
| issn | 1858-5051 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Sudan Journal of Medical Sciences |
| spelling | doaj-art-8276c9b61b7f41a39cab22692ab8be4c2025-01-21T05:40:18ZengKnowledge ESudan Journal of Medical Sciences1858-50512024-12-0119410.18502/sjms.v19i4.16404Short Telomere Length in Plasma of Sudanese Patients with Hepatocellular Carcinoma and Chronic Liver DiseasesFayza A. Rahamtalla0Iman M. Shammat1Salma B. M. Mudawi2Maram Abbas3Mohammed A. H. Kheir Elsid 4Mohammed S. M. Abdalla5Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, SudanDepartment of Basic Medical Sciences, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, SudanNational Center for GI and Liver Disease, IbnSina Hospital, Khartoum, SudanInstitute of Endemic diseases, Khartoum University, Khartoum, SudanFaculty of Medicine, Omdurman Islamic University, SudanAtomic Energy Commission (SAEC), Khartoum, Sudan Background: Telomeres, a protective sequence of DNA at the end of chromosomes, are essential for the maintenance of chromosomal integrity and stability. With each cell division, telomeres are shortened until a critical length is reached. Several cancers have been linked to shortened telomere length (TL). The current cross-sectional study aims to investigate the TL in the plasma of Sudanese patients with hepatocellular carcinoma (HCC) and chronic liver diseases (CLD). Methods: Blood samples were obtained from 113 patients with HCC and CLD as well as from 50 healthy controls. The assessment of TL in blood samples was carried out using the relative quantitative PCR method. Results: Patients with HCC had significantly shorter TL than healthy controls (0.66 vs 0.89; P < 0.01), whereas insignificant shorter TL was detected in HCC patients as compared to those with CLD. A significant decrease in telomeres copy numbers was observed in HCC patients when compared to those with CLD (P < 0.01). Conclusion: The results of the present study demonstrate that TL is shorter in patients with HCC and CLD compared to healthy controls. https://knepublishing.com/index.php/SJMS/article/view/16404telomere’s lengthtelomeres copy numbershepatocellular carcinomaCLDSudan |
| spellingShingle | Fayza A. Rahamtalla Iman M. Shammat Salma B. M. Mudawi Maram Abbas Mohammed A. H. Kheir Elsid Mohammed S. M. Abdalla Short Telomere Length in Plasma of Sudanese Patients with Hepatocellular Carcinoma and Chronic Liver Diseases Sudan Journal of Medical Sciences telomere’s length telomeres copy numbers hepatocellular carcinoma CLD Sudan |
| title | Short Telomere Length in Plasma of Sudanese Patients with Hepatocellular Carcinoma and Chronic Liver Diseases |
| title_full | Short Telomere Length in Plasma of Sudanese Patients with Hepatocellular Carcinoma and Chronic Liver Diseases |
| title_fullStr | Short Telomere Length in Plasma of Sudanese Patients with Hepatocellular Carcinoma and Chronic Liver Diseases |
| title_full_unstemmed | Short Telomere Length in Plasma of Sudanese Patients with Hepatocellular Carcinoma and Chronic Liver Diseases |
| title_short | Short Telomere Length in Plasma of Sudanese Patients with Hepatocellular Carcinoma and Chronic Liver Diseases |
| title_sort | short telomere length in plasma of sudanese patients with hepatocellular carcinoma and chronic liver diseases |
| topic | telomere’s length telomeres copy numbers hepatocellular carcinoma CLD Sudan |
| url | https://knepublishing.com/index.php/SJMS/article/view/16404 |
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