Systemic Inflammatory Response during Laparotomy
Background. The aim of this study was to analyze the influence of laparotomy on the systemic inflammatory response in human patients suffering from secondary peritonitis. Study Design. A prospective study investigating the levels of white blood cells, C-reactive protein, platelets, interleukin-six,...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/674303 |
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| _version_ | 1832564549075599360 |
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| author | Ahmad Mahamid Basel Jabarin Gidon Almogy |
| author_facet | Ahmad Mahamid Basel Jabarin Gidon Almogy |
| author_sort | Ahmad Mahamid |
| collection | DOAJ |
| description | Background. The aim of this study was to analyze the influence of laparotomy on the systemic inflammatory response in human patients suffering from secondary peritonitis. Study Design. A prospective study investigating the levels of white blood cells, C-reactive protein, platelets, interleukin-six, and tumor necrosis factor-alpha during laparotomy in five patients who suffered from secondary peritonitis. Six venous blood samples were collected perioperatively from each patient. The data were summarized by descriptive statistics and presented in a box plot. The hypothesis was that laparotomy increases the systemic inflammatory response, as has been described in animal models in previous studies. Results. The median age of the patients in this study was 84 years, the male to female ratio was 2 : 3, and the mortality rate was 80%. The most common cause of generalized peritonitis was ischemia of the colon. Analysis of the data showed no significant changes in the level of plasma inflammatory mediators during the surgical procedure, except for the platelet count which showed a significant decrease (P=0.001). Conclusions. In contrast to experience with animal models, laparotomy in human patients with secondary peritonitis did not significantly increase the systemic inflammatory response. Furthermore, it contributed in significantly decreasing some of the systemic inflammatory mediators. |
| format | Article |
| id | doaj-art-8262110db02940f79a40935ec64be22f |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-8262110db02940f79a40935ec64be22f2025-02-03T01:10:42ZengWileyInternational Journal of Inflammation2090-80402042-00992014-01-01201410.1155/2014/674303674303Systemic Inflammatory Response during LaparotomyAhmad Mahamid0Basel Jabarin1Gidon Almogy2Department of General Surgery, Hadassah-Hebrew University Medical Center, P.O. Box 12000, 91120 Jerusalem, IsraelDepartment of General Surgery, Hadassah-Hebrew University Medical Center, P.O. Box 12000, 91120 Jerusalem, IsraelDepartment of General Surgery, Hadassah-Hebrew University Medical Center, P.O. Box 12000, 91120 Jerusalem, IsraelBackground. The aim of this study was to analyze the influence of laparotomy on the systemic inflammatory response in human patients suffering from secondary peritonitis. Study Design. A prospective study investigating the levels of white blood cells, C-reactive protein, platelets, interleukin-six, and tumor necrosis factor-alpha during laparotomy in five patients who suffered from secondary peritonitis. Six venous blood samples were collected perioperatively from each patient. The data were summarized by descriptive statistics and presented in a box plot. The hypothesis was that laparotomy increases the systemic inflammatory response, as has been described in animal models in previous studies. Results. The median age of the patients in this study was 84 years, the male to female ratio was 2 : 3, and the mortality rate was 80%. The most common cause of generalized peritonitis was ischemia of the colon. Analysis of the data showed no significant changes in the level of plasma inflammatory mediators during the surgical procedure, except for the platelet count which showed a significant decrease (P=0.001). Conclusions. In contrast to experience with animal models, laparotomy in human patients with secondary peritonitis did not significantly increase the systemic inflammatory response. Furthermore, it contributed in significantly decreasing some of the systemic inflammatory mediators.http://dx.doi.org/10.1155/2014/674303 |
| spellingShingle | Ahmad Mahamid Basel Jabarin Gidon Almogy Systemic Inflammatory Response during Laparotomy International Journal of Inflammation |
| title | Systemic Inflammatory Response during Laparotomy |
| title_full | Systemic Inflammatory Response during Laparotomy |
| title_fullStr | Systemic Inflammatory Response during Laparotomy |
| title_full_unstemmed | Systemic Inflammatory Response during Laparotomy |
| title_short | Systemic Inflammatory Response during Laparotomy |
| title_sort | systemic inflammatory response during laparotomy |
| url | http://dx.doi.org/10.1155/2014/674303 |
| work_keys_str_mv | AT ahmadmahamid systemicinflammatoryresponseduringlaparotomy AT baseljabarin systemicinflammatoryresponseduringlaparotomy AT gidonalmogy systemicinflammatoryresponseduringlaparotomy |