CLINICAL AND IMMUNOLOGICAL EFFICACY OF THE RECOMBINANT INTERFERON alfa-2b OF ACUTE EPSTEIN-BARR VIRAL MONONUCLEOSIS IN PRESCHOOL CHILDREN
Conducted clinical and immunological examination of 51 children with acute Epstein-Barr viral mononucleosis (EBV) in age from 1 year to 7 years. All children diagnosed with a moderate degree of the disease. In the treatment of 25 people (comparison group) used the standard treatment (pathogenetic, s...
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LLC "Diagnostics and Vaccines"
2016-09-01
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| Series: | Детские инфекции (Москва) |
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| Online Access: | https://detinf.elpub.ru/jour/article/view/243 |
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| author | V. N. Timchenko S. L. Bannova N. M. Kalinina O. V. Bulina E. N. Vyzhlova A. N. Nazarova А. V. Fedorova |
| author_facet | V. N. Timchenko S. L. Bannova N. M. Kalinina O. V. Bulina E. N. Vyzhlova A. N. Nazarova А. V. Fedorova |
| author_sort | V. N. Timchenko |
| collection | DOAJ |
| description | Conducted clinical and immunological examination of 51 children with acute Epstein-Barr viral mononucleosis (EBV) in age from 1 year to 7 years. All children diagnosed with a moderate degree of the disease. In the treatment of 25 people (comparison group) used the standard treatment (pathogenetic, symptomatic), treatment 26 people (main group) included the use as antiviral and immunotropic means of the preparation of human recombinant interferon Alfa-2b in the form of rectal suppositories — VIFERON®. The immunological survey was conducted in dynamics: at the height of the disease and in the convalescence period. The blood was determined indicators of cellular immunity (leukocytes, lymphocytes, CD3+, CD4+, CD8+, CD56+, HLAII+, CD95+, CD1 6+, CD25+), the concentration of IFN-a, IFN-y, IL-4 levels in spontaneous and induced production, in the serum). At milestones children of the main group noted rapid regression of clinical symptoms, normalization of body temperature, reducing intoxication, positive dynamics lymphoproliferative syndrome), a significant reduction in bed-days, no layering respiratory viral infections. Interferon had also expressed a positive impact on the changed parameters of cellular immunity and cytokine links. At the same time, 80% of patients after basic treatment is established the predominance of Th2 type immune response, indicating a high risk of developing chronic course of EBV-mononucleosis. |
| format | Article |
| id | doaj-art-825b81d0e69640c5bd93b0caffb2d3cc |
| institution | DOAJ |
| issn | 2072-8107 |
| language | Russian |
| publishDate | 2016-09-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj-art-825b81d0e69640c5bd93b0caffb2d3cc2025-08-20T03:15:22ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072016-09-01153303810.22627/2072-8107-2016-15-3-30-38237CLINICAL AND IMMUNOLOGICAL EFFICACY OF THE RECOMBINANT INTERFERON alfa-2b OF ACUTE EPSTEIN-BARR VIRAL MONONUCLEOSIS IN PRESCHOOL CHILDRENV. N. Timchenko0S. L. Bannova1N. M. Kalinina2O. V. Bulina3E. N. Vyzhlova4A. N. Nazarova5А. V. Fedorova6Saint Petersburg State Pediatric Medical University of the Ministry of Halth of the Russian FederationSaint Petersburg State Pediatric Medical University of the Ministry of Halth of the Russian FederationAll-Russian Center of Emergency and Radiation Medicine named A.M. Nikiforov of EMERCOM RussiaSaint Petersburg State Pediatric Medical University of the Ministry of Halth of the Russian FederationResearch Institute of Microbiology and Epidemiology named N.F. Gamalei of the Ministry of Health of the Russian Federation , MoscowSaint Petersburg State Pediatric Medical University of the Ministry of Halth of the Russian FederationSaint Petersburg State Pediatric Medical University of the Ministry of Halth of the Russian FederationConducted clinical and immunological examination of 51 children with acute Epstein-Barr viral mononucleosis (EBV) in age from 1 year to 7 years. All children diagnosed with a moderate degree of the disease. In the treatment of 25 people (comparison group) used the standard treatment (pathogenetic, symptomatic), treatment 26 people (main group) included the use as antiviral and immunotropic means of the preparation of human recombinant interferon Alfa-2b in the form of rectal suppositories — VIFERON®. The immunological survey was conducted in dynamics: at the height of the disease and in the convalescence period. The blood was determined indicators of cellular immunity (leukocytes, lymphocytes, CD3+, CD4+, CD8+, CD56+, HLAII+, CD95+, CD1 6+, CD25+), the concentration of IFN-a, IFN-y, IL-4 levels in spontaneous and induced production, in the serum). At milestones children of the main group noted rapid regression of clinical symptoms, normalization of body temperature, reducing intoxication, positive dynamics lymphoproliferative syndrome), a significant reduction in bed-days, no layering respiratory viral infections. Interferon had also expressed a positive impact on the changed parameters of cellular immunity and cytokine links. At the same time, 80% of patients after basic treatment is established the predominance of Th2 type immune response, indicating a high risk of developing chronic course of EBV-mononucleosis.https://detinf.elpub.ru/jour/article/view/243acute ebv-mononucleosispreschool childrencellular and cytokine links of immunityrecombinant interferon alfa-2bviferon® |
| spellingShingle | V. N. Timchenko S. L. Bannova N. M. Kalinina O. V. Bulina E. N. Vyzhlova A. N. Nazarova А. V. Fedorova CLINICAL AND IMMUNOLOGICAL EFFICACY OF THE RECOMBINANT INTERFERON alfa-2b OF ACUTE EPSTEIN-BARR VIRAL MONONUCLEOSIS IN PRESCHOOL CHILDREN Детские инфекции (Москва) acute ebv-mononucleosis preschool children cellular and cytokine links of immunity recombinant interferon alfa-2b viferon® |
| title | CLINICAL AND IMMUNOLOGICAL EFFICACY OF THE RECOMBINANT INTERFERON alfa-2b OF ACUTE EPSTEIN-BARR VIRAL MONONUCLEOSIS IN PRESCHOOL CHILDREN |
| title_full | CLINICAL AND IMMUNOLOGICAL EFFICACY OF THE RECOMBINANT INTERFERON alfa-2b OF ACUTE EPSTEIN-BARR VIRAL MONONUCLEOSIS IN PRESCHOOL CHILDREN |
| title_fullStr | CLINICAL AND IMMUNOLOGICAL EFFICACY OF THE RECOMBINANT INTERFERON alfa-2b OF ACUTE EPSTEIN-BARR VIRAL MONONUCLEOSIS IN PRESCHOOL CHILDREN |
| title_full_unstemmed | CLINICAL AND IMMUNOLOGICAL EFFICACY OF THE RECOMBINANT INTERFERON alfa-2b OF ACUTE EPSTEIN-BARR VIRAL MONONUCLEOSIS IN PRESCHOOL CHILDREN |
| title_short | CLINICAL AND IMMUNOLOGICAL EFFICACY OF THE RECOMBINANT INTERFERON alfa-2b OF ACUTE EPSTEIN-BARR VIRAL MONONUCLEOSIS IN PRESCHOOL CHILDREN |
| title_sort | clinical and immunological efficacy of the recombinant interferon alfa 2b of acute epstein barr viral mononucleosis in preschool children |
| topic | acute ebv-mononucleosis preschool children cellular and cytokine links of immunity recombinant interferon alfa-2b viferon® |
| url | https://detinf.elpub.ru/jour/article/view/243 |
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