Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity
We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stress molecule on the surface of the tumor cells is u...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/4501273 |
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| author | T. N. Sharapova E. A. Romanova L. P. Sashchenko D. V. Yashin |
| author_facet | T. N. Sharapova E. A. Romanova L. P. Sashchenko D. V. Yashin |
| author_sort | T. N. Sharapova |
| collection | DOAJ |
| description | We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stress molecule on the surface of the tumor cells is used as a recognition target, while the Tag7 protein on the lymphocyte membrane acts as a receptor for Hsp70. We have also demonstrated that this subpopulation of the CD4+CD25+ cells is CD127 positive and hence is not the Treg cells. Our data suggest that this subpopulation of cells is identical to the CD4+CD25+ lymphocytes, which are activated in the leukocyte pool by the IL-2 cytokine. |
| format | Article |
| id | doaj-art-8252af72c55b438ca49eea1bb4478b86 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-8252af72c55b438ca49eea1bb4478b862025-02-03T07:24:56ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/45012734501273Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor ActivityT. N. Sharapova0E. A. Romanova1L. P. Sashchenko2D. V. Yashin3Institute of Gene Biology, RAS, 34/5 Vavilova Str, Moscow 119334, RussiaInstitute of Gene Biology, RAS, 34/5 Vavilova Str, Moscow 119334, RussiaInstitute of Gene Biology, RAS, 34/5 Vavilova Str, Moscow 119334, RussiaInstitute of Gene Biology, RAS, 34/5 Vavilova Str, Moscow 119334, RussiaWe have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stress molecule on the surface of the tumor cells is used as a recognition target, while the Tag7 protein on the lymphocyte membrane acts as a receptor for Hsp70. We have also demonstrated that this subpopulation of the CD4+CD25+ cells is CD127 positive and hence is not the Treg cells. Our data suggest that this subpopulation of cells is identical to the CD4+CD25+ lymphocytes, which are activated in the leukocyte pool by the IL-2 cytokine.http://dx.doi.org/10.1155/2018/4501273 |
| spellingShingle | T. N. Sharapova E. A. Romanova L. P. Sashchenko D. V. Yashin Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity Journal of Immunology Research |
| title | Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity |
| title_full | Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity |
| title_fullStr | Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity |
| title_full_unstemmed | Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity |
| title_short | Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity |
| title_sort | tag7 pglyrp1 can induce an emergence of the cd3 cd4 cd25 cd127 cells with antitumor activity |
| url | http://dx.doi.org/10.1155/2018/4501273 |
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