Influence of the Preparation Method on Some Characteristics of Alginate/Chitosan/Lovastatin Composites
This study investigates the effects of direct and indirect dispersion methods for lovastatin solid dispersion (LSD) in alginate (AG)/chitosan (CS) composites on the characteristics and properties of the AG/CS/LSD composites. The preparation method significantly influences the structure, morphology,...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Advances in Polymer Technology |
| Online Access: | http://dx.doi.org/10.1155/2020/7879368 |
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| _version_ | 1832547157528281088 |
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| author | Duc-Thuan Nghiem Thuy-Chinh Nguyen Minh-Thanh Do Thi-Huyen Nguyen Dai Lam Tran Tran-Dung Hoang Van-Quan Le Quoc-Trung Vu Duy-Trinh Nguyen Hoang Thai |
| author_facet | Duc-Thuan Nghiem Thuy-Chinh Nguyen Minh-Thanh Do Thi-Huyen Nguyen Dai Lam Tran Tran-Dung Hoang Van-Quan Le Quoc-Trung Vu Duy-Trinh Nguyen Hoang Thai |
| author_sort | Duc-Thuan Nghiem |
| collection | DOAJ |
| description | This study investigates the effects of direct and indirect dispersion methods for lovastatin solid dispersion (LSD) in alginate (AG)/chitosan (CS) composites on the characteristics and properties of the AG/CS/LSD composites. The preparation method significantly influences the structure, morphology, and LSD size distribution of the composites as well as the drug release of LSD from the samples. The differences in dispersion methods for LSD lead to differences in the interaction between the components, the structure, and the control drug release of LSD. Lovastatin was released from the samples containing LSD in two stages (a fast release stage and a slow release stage), and the drug release content prepared using the indirect method is lower than that prepared using the direct method in the same buffer solution. After 32 h of testing, the released LSD content from the indirect and direct LSD dispersion methods in pH 2 and pH 7.4 buffer solutions was 87–94% and 41–61%, respectively. Drug release kinetics from the above samples in solutions with different pH values was also set up. |
| format | Article |
| id | doaj-art-825065733c934de697904f5c667a9dfd |
| institution | Kabale University |
| issn | 0730-6679 1098-2329 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Polymer Technology |
| spelling | doaj-art-825065733c934de697904f5c667a9dfd2025-02-03T06:45:54ZengWileyAdvances in Polymer Technology0730-66791098-23292020-01-01202010.1155/2020/78793687879368Influence of the Preparation Method on Some Characteristics of Alginate/Chitosan/Lovastatin CompositesDuc-Thuan Nghiem0Thuy-Chinh Nguyen1Minh-Thanh Do2Thi-Huyen Nguyen3Dai Lam Tran4Tran-Dung Hoang5Van-Quan Le6Quoc-Trung Vu7Duy-Trinh Nguyen8Hoang Thai9Military Hospital 103, Vietnam Military Medical University, 261 Phung Hung, Phuc La, Ha Dong, Hanoi 100000, VietnamInstitute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamInstitute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamHanoi National University of Education, No. 136 Xuan Thuy Road, Cau Giay, Hanoi 100000, VietnamInstitute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamInstitute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamMilitary Hospital 103, Vietnam Military Medical University, 261 Phung Hung, Phuc La, Ha Dong, Hanoi 100000, VietnamHanoi National University of Education, No. 136 Xuan Thuy Road, Cau Giay, Hanoi 100000, VietnamNguyen Tat Thanh University, 300A Nguyen Tat Thanh, District 4, Ho Chi Minh City 700000, VietnamInstitute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamThis study investigates the effects of direct and indirect dispersion methods for lovastatin solid dispersion (LSD) in alginate (AG)/chitosan (CS) composites on the characteristics and properties of the AG/CS/LSD composites. The preparation method significantly influences the structure, morphology, and LSD size distribution of the composites as well as the drug release of LSD from the samples. The differences in dispersion methods for LSD lead to differences in the interaction between the components, the structure, and the control drug release of LSD. Lovastatin was released from the samples containing LSD in two stages (a fast release stage and a slow release stage), and the drug release content prepared using the indirect method is lower than that prepared using the direct method in the same buffer solution. After 32 h of testing, the released LSD content from the indirect and direct LSD dispersion methods in pH 2 and pH 7.4 buffer solutions was 87–94% and 41–61%, respectively. Drug release kinetics from the above samples in solutions with different pH values was also set up.http://dx.doi.org/10.1155/2020/7879368 |
| spellingShingle | Duc-Thuan Nghiem Thuy-Chinh Nguyen Minh-Thanh Do Thi-Huyen Nguyen Dai Lam Tran Tran-Dung Hoang Van-Quan Le Quoc-Trung Vu Duy-Trinh Nguyen Hoang Thai Influence of the Preparation Method on Some Characteristics of Alginate/Chitosan/Lovastatin Composites Advances in Polymer Technology |
| title | Influence of the Preparation Method on Some Characteristics of Alginate/Chitosan/Lovastatin Composites |
| title_full | Influence of the Preparation Method on Some Characteristics of Alginate/Chitosan/Lovastatin Composites |
| title_fullStr | Influence of the Preparation Method on Some Characteristics of Alginate/Chitosan/Lovastatin Composites |
| title_full_unstemmed | Influence of the Preparation Method on Some Characteristics of Alginate/Chitosan/Lovastatin Composites |
| title_short | Influence of the Preparation Method on Some Characteristics of Alginate/Chitosan/Lovastatin Composites |
| title_sort | influence of the preparation method on some characteristics of alginate chitosan lovastatin composites |
| url | http://dx.doi.org/10.1155/2020/7879368 |
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