Exploring the Association Between Gastroesophageal Reflux and Temporomandibular Joint Disorder in European Populations: A Bidirectional Mendelian Randomization Analysis
Introduction and aims: Gastroesophageal reflux disease (GERD) and temporomandibular joint disorder (TMD) are relatively common conditions with a potential causal relationship. This study aims to investigate the possible causal relationship between GERD and TMD through bidirectional Mendelian randomi...
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Elsevier
2025-02-01
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| Series: | International Dental Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0020653924014011 |
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| author | Renjie Gu Liangqiong Chen Minhui Hua Huangtai Miao Yongwei Qin |
| author_facet | Renjie Gu Liangqiong Chen Minhui Hua Huangtai Miao Yongwei Qin |
| author_sort | Renjie Gu |
| collection | DOAJ |
| description | Introduction and aims: Gastroesophageal reflux disease (GERD) and temporomandibular joint disorder (TMD) are relatively common conditions with a potential causal relationship. This study aims to investigate the possible causal relationship between GERD and TMD through bidirectional Mendelian randomization analysis. Methods: Using data from large GWAS databases, we conducted bidirectional Mendelian randomization analyses to investigate the potential causal link between GERD and TMD. Instrumental variables were selected from the IEU platform, comprising 129,080 GERD cases and 473,524 controls from the UK Biobank. TMD data from the FinnGen project included 6,314 cases and 222,498 controls. Results: The forward MR analysis suggested that GERD may increase the risk of TMD (OR = 1.47, 95% CI: 1.20-1.81, P = 2e-4). The Weighted Median method also yielded significant results (OR = 1.53, 95% CI: 1.14-2.04, P = 4.1e-3). However, the reverse MR analysis did not reveal a significant association between TMD and GERD (OR = 1.02, 95% CI: 0.98-1.05, P = .33). Conclusion: This study, employing MR analysis, provides initial evidence supporting a potential causal relationship between GERD and TMD. The findings contribute to a better understanding of the relationship between these two conditions and offer insights for future clinical investigations. Clinical relevance: The findings of this study hold potential clinical significance in guiding early management strategies for GERD, reducing the incidence of TMD, and optimizing healthcare resource allocation, thereby improving patient quality of life. Further clinical studies are warranted to validate these findings and explore underlying mechanisms. |
| format | Article |
| id | doaj-art-82468e2656d44bb8b91acf0a65861887 |
| institution | Kabale University |
| issn | 0020-6539 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Dental Journal |
| spelling | doaj-art-82468e2656d44bb8b91acf0a658618872025-01-21T04:12:44ZengElsevierInternational Dental Journal0020-65392025-02-01751288294Exploring the Association Between Gastroesophageal Reflux and Temporomandibular Joint Disorder in European Populations: A Bidirectional Mendelian Randomization AnalysisRenjie Gu0Liangqiong Chen1Minhui Hua2Huangtai Miao3Yongwei Qin4Department of Pathogen Biology, Medical College, Nantong University, 19 Qixiu Road, Nantong, 226001, Jiangsu, ChinaDepartment of Laboratory Medicine, Haian People's Hospital, Haian, 226600, Jiangsu, ChinaDepartment of Gynecology and Obstetrics, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, ChinaCenter for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100013, ChinaDepartment of Pathogen Biology, Medical College, Nantong University, 19 Qixiu Road, Nantong, 226001, Jiangsu, China; Corresponding author. Department of Pathogen Biology, Medical College, Nantong University, 19 Qixiu Road, Nantong, 226001, Jiangsu, China.Introduction and aims: Gastroesophageal reflux disease (GERD) and temporomandibular joint disorder (TMD) are relatively common conditions with a potential causal relationship. This study aims to investigate the possible causal relationship between GERD and TMD through bidirectional Mendelian randomization analysis. Methods: Using data from large GWAS databases, we conducted bidirectional Mendelian randomization analyses to investigate the potential causal link between GERD and TMD. Instrumental variables were selected from the IEU platform, comprising 129,080 GERD cases and 473,524 controls from the UK Biobank. TMD data from the FinnGen project included 6,314 cases and 222,498 controls. Results: The forward MR analysis suggested that GERD may increase the risk of TMD (OR = 1.47, 95% CI: 1.20-1.81, P = 2e-4). The Weighted Median method also yielded significant results (OR = 1.53, 95% CI: 1.14-2.04, P = 4.1e-3). However, the reverse MR analysis did not reveal a significant association between TMD and GERD (OR = 1.02, 95% CI: 0.98-1.05, P = .33). Conclusion: This study, employing MR analysis, provides initial evidence supporting a potential causal relationship between GERD and TMD. The findings contribute to a better understanding of the relationship between these two conditions and offer insights for future clinical investigations. Clinical relevance: The findings of this study hold potential clinical significance in guiding early management strategies for GERD, reducing the incidence of TMD, and optimizing healthcare resource allocation, thereby improving patient quality of life. Further clinical studies are warranted to validate these findings and explore underlying mechanisms.http://www.sciencedirect.com/science/article/pii/S0020653924014011GERDTMDMendelian randomizationInstrumental variablesGWAS |
| spellingShingle | Renjie Gu Liangqiong Chen Minhui Hua Huangtai Miao Yongwei Qin Exploring the Association Between Gastroesophageal Reflux and Temporomandibular Joint Disorder in European Populations: A Bidirectional Mendelian Randomization Analysis International Dental Journal GERD TMD Mendelian randomization Instrumental variables GWAS |
| title | Exploring the Association Between Gastroesophageal Reflux and Temporomandibular Joint Disorder in European Populations: A Bidirectional Mendelian Randomization Analysis |
| title_full | Exploring the Association Between Gastroesophageal Reflux and Temporomandibular Joint Disorder in European Populations: A Bidirectional Mendelian Randomization Analysis |
| title_fullStr | Exploring the Association Between Gastroesophageal Reflux and Temporomandibular Joint Disorder in European Populations: A Bidirectional Mendelian Randomization Analysis |
| title_full_unstemmed | Exploring the Association Between Gastroesophageal Reflux and Temporomandibular Joint Disorder in European Populations: A Bidirectional Mendelian Randomization Analysis |
| title_short | Exploring the Association Between Gastroesophageal Reflux and Temporomandibular Joint Disorder in European Populations: A Bidirectional Mendelian Randomization Analysis |
| title_sort | exploring the association between gastroesophageal reflux and temporomandibular joint disorder in european populations a bidirectional mendelian randomization analysis |
| topic | GERD TMD Mendelian randomization Instrumental variables GWAS |
| url | http://www.sciencedirect.com/science/article/pii/S0020653924014011 |
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