Bioactive milk-derived nutrient MFG-E8 ameliorates skeletal muscle atrophy induced by mitochondria damage in aging rats via activating the MAPK/ERK signaling pathway

Bioactive milk-derived nutrient MFG-E8 ameliorates skeletal muscle atrophy induced by mitochondria damage in aging rats via activating the MAPK/ERK signaling pathway

ABSTRACT: Sarcopenia is the age-related loss of muscle and fiber number and decreased regenerative capacity with increased abundance of reactive oxygen species levels and electron transport chain abnormalities. The aim of this study was to investigate the antisarcopenia effect of MFG-E8 in alleviati...

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Bibliographic Details
Main Authors: Kaifang Guan, Xiaolin Liu, Weihong Lu, Yuhao Mao, Yirong Mao, Ying Ma, Rongchu Wang, Qiming Li
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Journal of Dairy Science
Subjects:
MFG-E8
skeletal muscle atrophy
mitochondria
ERK signaling pathway
cell cycle
Online Access:http://www.sciencedirect.com/science/article/pii/S0022030224012414
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