Prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples: systematic review and meta-analysis
Abstract Background This systematic review and meta-analysis evaluates the prevalence of disruptive mood dysregulation disorders (DMDD) in community-based and clinical populations. Methods PubMed and PsychINFO databases were searched, using terms specific to DMDD, for studies of prevalence and c...
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Cambridge University Press
2025-01-01
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| Series: | European Psychiatry |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933824018133/type/journal_article |
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| author | Xavier Benarous Hélène Lahaye Angèle Consoli David Cohen Réal Labelle Jean-Marc Guilé |
| author_facet | Xavier Benarous Hélène Lahaye Angèle Consoli David Cohen Réal Labelle Jean-Marc Guilé |
| author_sort | Xavier Benarous |
| collection | DOAJ |
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Abstract
Background
This systematic review and meta-analysis evaluates the prevalence of disruptive mood dysregulation disorders (DMDD) in community-based and clinical populations.
Methods
PubMed and PsychINFO databases were searched, using terms specific to DMDD, for studies of prevalence and comorbidity rates conducted in youths below 18.
Results
Fourteen studies reporting data from 2013 to 2023 were included. The prevalence of DMDD in the community-based samples was 3.3% (95% confidence interval [CI], 1.4–6.0) and 21.9% (95% CI, 15.5–29.0) in the clinical population. The differences in the identification strategy of DMDD were associated with significant heterogeneity between studies in the community-based samples, with a prevalence of 0.82% (95% CI, 0.11–2.13) when all diagnosis criteria were considered. Anxiety, depressive disorders, and ADHD were the most frequent comorbidity present with DMDD. The association with other neurodevelopmental disorders remained poorly investigated.
Conclusions
Caution is required when interpreting these findings, considering the quality of the reviewed data and the level of unexplained heterogeneity among studies. This review stresses the importance of considering a strict adhesion to DMDD criteria when exploring its clinical correlates.
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| format | Article |
| id | doaj-art-822b62b1f9344ddabde72b08dc58e52f |
| institution | Kabale University |
| issn | 0924-9338 1778-3585 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj-art-822b62b1f9344ddabde72b08dc58e52f2025-01-21T06:18:17ZengCambridge University PressEuropean Psychiatry0924-93381778-35852025-01-016810.1192/j.eurpsy.2024.1813Prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples: systematic review and meta-analysisXavier Benarous0https://orcid.org/0000-0003-1994-5779Hélène Lahaye1Angèle Consoli2https://orcid.org/0000-0003-1357-6538David Cohen3Réal Labelle4https://orcid.org/0000-0002-5661-9254Jean-Marc Guilé5INSERM UMR-S 1136 IPLESP-ESSMA (Pierre Louis Institute of Epidemiology, Team Social Epidemiology, Mental Health, Addictions), Paris, France Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, APHP.Sorbonne-Université, Paris, FranceDepartment of Child and Adolescent Psychopathology, Amiens University Hospital, Amiens, France INSERM Unit U1105 Research Group for Analysis of the Multimodal Cerebral Function, University of Picardy Jules Verne (UPJV), Amiens, FranceINSERM UMR-S 1136 IPLESP-ESSMA (Pierre Louis Institute of Epidemiology, Team Social Epidemiology, Mental Health, Addictions), Paris, France Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, APHP.Sorbonne-Université, Paris, FranceDepartment of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, APHP.Sorbonne-Université, Paris, France CNRS UMR 7222, Institute for Intelligent Systems and Robotics, Sorbonne University, Paris, FranceDepartment of Psychology, Quebec University, Montreal, QC, Canada Centre for Research and Intervention on Suicide, Ethical Issues and End-of-Life Practices, Quebec University, Montreal, QC, CanadaDepartment of Child and Adolescent Psychopathology, Amiens University Hospital, Amiens, France INSERM Unit U1105 Research Group for Analysis of the Multimodal Cerebral Function, University of Picardy Jules Verne (UPJV), Amiens, France Department of Psychiatry, McGill University, Montreal, QC, Canada Department of Child and Adolescent Psychiatry, Etablissment Publique de Santé Mentale (EPSM) de la Somme, Amiens, France Abstract Background This systematic review and meta-analysis evaluates the prevalence of disruptive mood dysregulation disorders (DMDD) in community-based and clinical populations. Methods PubMed and PsychINFO databases were searched, using terms specific to DMDD, for studies of prevalence and comorbidity rates conducted in youths below 18. Results Fourteen studies reporting data from 2013 to 2023 were included. The prevalence of DMDD in the community-based samples was 3.3% (95% confidence interval [CI], 1.4–6.0) and 21.9% (95% CI, 15.5–29.0) in the clinical population. The differences in the identification strategy of DMDD were associated with significant heterogeneity between studies in the community-based samples, with a prevalence of 0.82% (95% CI, 0.11–2.13) when all diagnosis criteria were considered. Anxiety, depressive disorders, and ADHD were the most frequent comorbidity present with DMDD. The association with other neurodevelopmental disorders remained poorly investigated. Conclusions Caution is required when interpreting these findings, considering the quality of the reviewed data and the level of unexplained heterogeneity among studies. This review stresses the importance of considering a strict adhesion to DMDD criteria when exploring its clinical correlates. https://www.cambridge.org/core/product/identifier/S0924933824018133/type/journal_articleaggressiondepressive disorderemotional dysregulationirritabilitymood dysregulationpediatric depressiontemper outburst |
| spellingShingle | Xavier Benarous Hélène Lahaye Angèle Consoli David Cohen Réal Labelle Jean-Marc Guilé Prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples: systematic review and meta-analysis European Psychiatry aggression depressive disorder emotional dysregulation irritability mood dysregulation pediatric depression temper outburst |
| title | Prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples: systematic review and meta-analysis |
| title_full | Prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples: systematic review and meta-analysis |
| title_fullStr | Prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples: systematic review and meta-analysis |
| title_full_unstemmed | Prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples: systematic review and meta-analysis |
| title_short | Prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples: systematic review and meta-analysis |
| title_sort | prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples systematic review and meta analysis |
| topic | aggression depressive disorder emotional dysregulation irritability mood dysregulation pediatric depression temper outburst |
| url | https://www.cambridge.org/core/product/identifier/S0924933824018133/type/journal_article |
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