Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance
Background. Pancreatic tumors are rare and could arise from either the exocrine (ductal and acinar cells) or the endocrine (neuroendocrine cells) components of the pancreas. In some instances, the occurrence of pancreatic tumors comprising both acinar cells and neuroendocrine cells, with neuroendocr...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/705092 |
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| author | Onyekachi Henry Ogbonna Marie Carmel Garcon Kostas N. Syrigos Muhammad Wasif Saif |
| author_facet | Onyekachi Henry Ogbonna Marie Carmel Garcon Kostas N. Syrigos Muhammad Wasif Saif |
| author_sort | Onyekachi Henry Ogbonna |
| collection | DOAJ |
| description | Background. Pancreatic tumors are rare and could arise from either the exocrine (ductal and acinar cells) or the endocrine (neuroendocrine cells) components of the pancreas. In some instances, the occurrence of pancreatic tumors comprising both acinar cells and neuroendocrine cells, with neuroendocrine cells making up more than 30% of the tumor, has been identified. This unique entity has been referred to as mixed acinar-neuroendocrine carcinoma (MANEC). Only about 20 such cases have been reported in the literature. Case Report. We report an interesting case of MANEC with neuroendocrine cell predominance in a woman presenting with epigastric pain secondary to a pancreatic mass with acinar and endocrine differentiation. She underwent surgical resection of the tumor and was offered adjuvant treatment chemotherapy with carboplatin, etoposide, and radiotherapy for positive tumor resection margins. Conclusions. Given the paucity of the cases of MANEC, continuous reporting of these cases when identified should be encouraged to aid oncologists in understanding the disease and help establish standardized management. |
| format | Article |
| id | doaj-art-82169139a84e4b319ab98b2149a35410 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-82169139a84e4b319ab98b2149a354102025-02-03T06:14:18ZengWileyCase Reports in Medicine1687-96271687-96352013-01-01201310.1155/2013/705092705092Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine PredominanceOnyekachi Henry Ogbonna0Marie Carmel Garcon1Kostas N. Syrigos2Muhammad Wasif Saif3Section of GI Cancers and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USAColumbia University Medical Center, New York, NY 10032, USAOncology Unit, Third Department of Medicine, Athens University, School of Medicine, Sotiria General Hospital, 115 27 Athens, GreeceSection of GI Cancers and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USABackground. Pancreatic tumors are rare and could arise from either the exocrine (ductal and acinar cells) or the endocrine (neuroendocrine cells) components of the pancreas. In some instances, the occurrence of pancreatic tumors comprising both acinar cells and neuroendocrine cells, with neuroendocrine cells making up more than 30% of the tumor, has been identified. This unique entity has been referred to as mixed acinar-neuroendocrine carcinoma (MANEC). Only about 20 such cases have been reported in the literature. Case Report. We report an interesting case of MANEC with neuroendocrine cell predominance in a woman presenting with epigastric pain secondary to a pancreatic mass with acinar and endocrine differentiation. She underwent surgical resection of the tumor and was offered adjuvant treatment chemotherapy with carboplatin, etoposide, and radiotherapy for positive tumor resection margins. Conclusions. Given the paucity of the cases of MANEC, continuous reporting of these cases when identified should be encouraged to aid oncologists in understanding the disease and help establish standardized management.http://dx.doi.org/10.1155/2013/705092 |
| spellingShingle | Onyekachi Henry Ogbonna Marie Carmel Garcon Kostas N. Syrigos Muhammad Wasif Saif Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance Case Reports in Medicine |
| title | Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance |
| title_full | Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance |
| title_fullStr | Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance |
| title_full_unstemmed | Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance |
| title_short | Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance |
| title_sort | mixed acinar neuroendocrine carcinoma of the pancreas with neuroendocrine predominance |
| url | http://dx.doi.org/10.1155/2013/705092 |
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