Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis
Herpes simplex virus type 2 (HSV-2) is the cause of most genital herpes while HSV-1 is responsible for orolabial and facial lesions. In immunocompromised individuals, like HIV patients, impaired immunity leads to more frequent symptomatic and asymptomatic HSV infection. Fifty-two blood samples from...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2015/537939 |
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| author | Soumyabrata Nag Soma Sarkar Debprasad Chattopadhyay Sanjoy Bhattacharya Rahul Biswas Manideepa SenGupta |
| author_facet | Soumyabrata Nag Soma Sarkar Debprasad Chattopadhyay Sanjoy Bhattacharya Rahul Biswas Manideepa SenGupta |
| author_sort | Soumyabrata Nag |
| collection | DOAJ |
| description | Herpes simplex virus type 2 (HSV-2) is the cause of most genital herpes while HSV-1 is responsible for orolabial and facial lesions. In immunocompromised individuals, like HIV patients, impaired immunity leads to more frequent symptomatic and asymptomatic HSV infection. Fifty-two blood samples from HIV patients with clinically diagnosed HSV infection were taken as cases, while 45 blood samples each from HIV-infected (HIV control) and noninfected patients without any herpetic lesion (non-HIV control) were taken as control. Serum was tested for IgM and IgG antibodies of both HSV-1 and HSV-2 by ELISA. The seroprevalence was compared among the three groups of study population, considering the demographic and socioeconomic parameters. The HSV-2 IgM was significantly higher (p<0.005) in the HIV patient group (34.6%) than the HIV control (2.2%) and non-HIV control (2.2%) groups, whereas HSV-2 IgG seroprevalence was higher in both HIV patient (61.5%) and HIV control (57.8%) groups than the non-HIV control group (17.8%). The prevalence of HSV-2 was significantly higher in persons with multiple partners and in the reproductive age group. The overall seroprevalence of HSV-1 IgM was too low (<5%), whereas it was too high (about 90%) with HSV-1 IgG in all three study groups. |
| format | Article |
| id | doaj-art-821151de9c9740c990fe6d19bd1148f6 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-821151de9c9740c990fe6d19bd1148f62025-02-03T01:00:33ZengWileyAdvances in Virology1687-86391687-86472015-01-01201510.1155/2015/537939537939Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor AnalysisSoumyabrata Nag0Soma Sarkar1Debprasad Chattopadhyay2Sanjoy Bhattacharya3Rahul Biswas4Manideepa SenGupta5Department of Microbiology, IIMSAR & BCRH, Haldia, West Bengal, IndiaDepartment of Microbiology, Medical College Kolkata, 88 College Street, Kolkata, West Bengal, IndiaICMR Virus Unit, I.D. and B.G. Hospital, GB-4, 1st Floor, 57 Dr. S. C. Banerjee Road, Beliaghata, Kolkata, IndiaDepartment of Medicine, Medical College Kolkata, 88 College Street, Kolkata, West Bengal, IndiaDepartment of Community Medicine, A.I.I.H. & P.H., Kolkata, West Bengal, IndiaDepartment of Microbiology, Medical College Kolkata, 88 College Street, Kolkata, West Bengal, IndiaHerpes simplex virus type 2 (HSV-2) is the cause of most genital herpes while HSV-1 is responsible for orolabial and facial lesions. In immunocompromised individuals, like HIV patients, impaired immunity leads to more frequent symptomatic and asymptomatic HSV infection. Fifty-two blood samples from HIV patients with clinically diagnosed HSV infection were taken as cases, while 45 blood samples each from HIV-infected (HIV control) and noninfected patients without any herpetic lesion (non-HIV control) were taken as control. Serum was tested for IgM and IgG antibodies of both HSV-1 and HSV-2 by ELISA. The seroprevalence was compared among the three groups of study population, considering the demographic and socioeconomic parameters. The HSV-2 IgM was significantly higher (p<0.005) in the HIV patient group (34.6%) than the HIV control (2.2%) and non-HIV control (2.2%) groups, whereas HSV-2 IgG seroprevalence was higher in both HIV patient (61.5%) and HIV control (57.8%) groups than the non-HIV control group (17.8%). The prevalence of HSV-2 was significantly higher in persons with multiple partners and in the reproductive age group. The overall seroprevalence of HSV-1 IgM was too low (<5%), whereas it was too high (about 90%) with HSV-1 IgG in all three study groups.http://dx.doi.org/10.1155/2015/537939 |
| spellingShingle | Soumyabrata Nag Soma Sarkar Debprasad Chattopadhyay Sanjoy Bhattacharya Rahul Biswas Manideepa SenGupta Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis Advances in Virology |
| title | Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis |
| title_full | Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis |
| title_fullStr | Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis |
| title_full_unstemmed | Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis |
| title_short | Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis |
| title_sort | seroprevalence of herpes simplex virus infection in hiv coinfected individuals in eastern india with risk factor analysis |
| url | http://dx.doi.org/10.1155/2015/537939 |
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