Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing

Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing

During the development process of therapeutic monoclonal antibodies (mAbs), it is crucial to control (critical) quality attributes such as N-glycosylation influencing pharmacokinetics (PK) and Fc effector functions. Previous reports have shown that mAbs containing high-mannose N-glycans are cleared...

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Bibliographic Details
Main Authors: Julia Baumeister, Maximilian Meudt, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Kristina M. J. Aertker, Fabian Higel
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
N-glycosylation
high-mannose
glycan-pairing
mannose receptor
monoclonal antibody
pharmacokinetics
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2400414
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