MXenes in biosensing: Enhancing sensitivity and flexibility – A review of properties, applications, and future directions
MXenes are a novel type of nanostructured material that has received a lot of attention for their potential applications in bioanalysis owing to their unique features. These materials, made from transition metal nitrides, carbides, or carbonitrides, have a number of advantages, including high hydrop...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Sensing and Bio-Sensing Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214180424001144 |
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| author | Ali Mohammad Amani Lobat Tayebi Ehsan Vafa Alireza Jahanbin Milad Abbasi Ahmad Vaez Hesam Kamyab Lalitha Gnanasekaran Shreeshivadasan Chelliapan |
| author_facet | Ali Mohammad Amani Lobat Tayebi Ehsan Vafa Alireza Jahanbin Milad Abbasi Ahmad Vaez Hesam Kamyab Lalitha Gnanasekaran Shreeshivadasan Chelliapan |
| author_sort | Ali Mohammad Amani |
| collection | DOAJ |
| description | MXenes are a novel type of nanostructured material that has received a lot of attention for their potential applications in bioanalysis owing to their unique features. These materials, made from transition metal nitrides, carbides, or carbonitrides, have a number of advantages, including high hydrophilicity, a large surface area, strong metallic conductivity, superior ion transport capabilities, biocompatibility, and low diffusion barriers. Their surfaces are easily manipulated, making them more adaptable for a variety of applications, including biosensing. The outstanding properties of MXenes have attracted researchers of different fields, including renewable energy, fuel cells, supercapacitors, electronics, and catalysis. In the context of biosensing, MXenes are particularly noteworthy because of their layered structure and composition, which render them suitable for both electrochemical and optical biosensors. The high electrical conductivity and multilayered design of MXenes facilitate effective charge transport and the preservation of biological activity when biomolecules are attached to their surfaces. This characteristic positions them as ideal candidates for the creation of sensitive and efficient electrochemical biosensors. Moreover, the inherent flexibility of MXenes allows for the development of sensors compatible with wearable technologies, presenting substantial opportunities for real-time, on-body detection of biomolecules. This review looks at various applications of MXenes in electrochemical and optical biosensing, with a focus on how they help improve sensor performance metrics like sensitivity, stability, and biocompatibility. It also discusses the obstacles and limitations that must be overcome to fully realize MXenes' potential in biosensor technology, such as issues with large-scale manufacturing, surface modification, and long-term stability. The review concludes by discussing future directions and advancements in this field. |
| format | Article |
| id | doaj-art-82050a37f9bc40008264b96829bb6156 |
| institution | Kabale University |
| issn | 2214-1804 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensing and Bio-Sensing Research |
| spelling | doaj-art-82050a37f9bc40008264b96829bb61562025-01-23T05:26:42ZengElsevierSensing and Bio-Sensing Research2214-18042025-02-0147100732MXenes in biosensing: Enhancing sensitivity and flexibility – A review of properties, applications, and future directionsAli Mohammad Amani0Lobat Tayebi1Ehsan Vafa2Alireza Jahanbin3Milad Abbasi4Ahmad Vaez5Hesam Kamyab6Lalitha Gnanasekaran7Shreeshivadasan Chelliapan8Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; Corresponding authors.Institute for Engineering in Medicine, Health & Human Performance (EnMed), Batten College of Engineering and Technology, Old Dominion University, Norfolk, VA 23529, USADepartment of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Materials Science and Engineering, School of Engineering, Shiraz University, Zand Blvd., Shiraz 7134851154, IranDepartment of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Biomaterials, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai 600077, India; The KU-KIST Graduate School of Energy and Environment, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul 02841, Republic of Korea; Faculty of Social Sciences, Media and Communication, University of Religions and Denominations, Pardisan, Qom, Iran; Corresponding author at: The KU-KIST Graduate School of Energy and Environment, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul, 02841, Republic of KoreaInstituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, ChileDepartment of Smart Engineering and Advanced Technology, Faculty of Artificial Intelligence, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia; Corresponding authors.MXenes are a novel type of nanostructured material that has received a lot of attention for their potential applications in bioanalysis owing to their unique features. These materials, made from transition metal nitrides, carbides, or carbonitrides, have a number of advantages, including high hydrophilicity, a large surface area, strong metallic conductivity, superior ion transport capabilities, biocompatibility, and low diffusion barriers. Their surfaces are easily manipulated, making them more adaptable for a variety of applications, including biosensing. The outstanding properties of MXenes have attracted researchers of different fields, including renewable energy, fuel cells, supercapacitors, electronics, and catalysis. In the context of biosensing, MXenes are particularly noteworthy because of their layered structure and composition, which render them suitable for both electrochemical and optical biosensors. The high electrical conductivity and multilayered design of MXenes facilitate effective charge transport and the preservation of biological activity when biomolecules are attached to their surfaces. This characteristic positions them as ideal candidates for the creation of sensitive and efficient electrochemical biosensors. Moreover, the inherent flexibility of MXenes allows for the development of sensors compatible with wearable technologies, presenting substantial opportunities for real-time, on-body detection of biomolecules. This review looks at various applications of MXenes in electrochemical and optical biosensing, with a focus on how they help improve sensor performance metrics like sensitivity, stability, and biocompatibility. It also discusses the obstacles and limitations that must be overcome to fully realize MXenes' potential in biosensor technology, such as issues with large-scale manufacturing, surface modification, and long-term stability. The review concludes by discussing future directions and advancements in this field.http://www.sciencedirect.com/science/article/pii/S2214180424001144MXenesElectrochemical biosensorsDetectionElectronicsHealthcare |
| spellingShingle | Ali Mohammad Amani Lobat Tayebi Ehsan Vafa Alireza Jahanbin Milad Abbasi Ahmad Vaez Hesam Kamyab Lalitha Gnanasekaran Shreeshivadasan Chelliapan MXenes in biosensing: Enhancing sensitivity and flexibility – A review of properties, applications, and future directions Sensing and Bio-Sensing Research MXenes Electrochemical biosensors Detection Electronics Healthcare |
| title | MXenes in biosensing: Enhancing sensitivity and flexibility – A review of properties, applications, and future directions |
| title_full | MXenes in biosensing: Enhancing sensitivity and flexibility – A review of properties, applications, and future directions |
| title_fullStr | MXenes in biosensing: Enhancing sensitivity and flexibility – A review of properties, applications, and future directions |
| title_full_unstemmed | MXenes in biosensing: Enhancing sensitivity and flexibility – A review of properties, applications, and future directions |
| title_short | MXenes in biosensing: Enhancing sensitivity and flexibility – A review of properties, applications, and future directions |
| title_sort | mxenes in biosensing enhancing sensitivity and flexibility a review of properties applications and future directions |
| topic | MXenes Electrochemical biosensors Detection Electronics Healthcare |
| url | http://www.sciencedirect.com/science/article/pii/S2214180424001144 |
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