Bladder Cancer Invading the Prostate and Penis and Multiple Bone Metastases Showing Significant Improvement after a Short-Term Pembrolizumab Therapy following Radiation and Gemcitabine and Cisplatin Therapy Leading to a Pathologically Complete Remission
A 65-year-old man was diagnosed with bladder cancer invading the prostate and penis and multiple bone metastases. He underwent palliative radiation (30 Gy/10 fr) through vertebral bones (Th3 and Th12-L5) and pelvic bones for pain control. The patient received pembrolizumab therapy after three course...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2024/7525757 |
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| author | Kyohei Ishida Akira Ogose Gen Kawaguchi Go Hasegawa Yohei Ikeda Noboru Hara Tsutomu Nishiyama |
| author_facet | Kyohei Ishida Akira Ogose Gen Kawaguchi Go Hasegawa Yohei Ikeda Noboru Hara Tsutomu Nishiyama |
| author_sort | Kyohei Ishida |
| collection | DOAJ |
| description | A 65-year-old man was diagnosed with bladder cancer invading the prostate and penis and multiple bone metastases. He underwent palliative radiation (30 Gy/10 fr) through vertebral bones (Th3 and Th12-L5) and pelvic bones for pain control. The patient received pembrolizumab therapy after three courses of gemcitabine and cisplatin therapy. CT four weeks after starting pembrolizumab therapy showed that both the primary and metastatic lesions had notably reduced in size, and no new lesion was detected. He subsequently fell, resulting in a femoral neck pathological fracture, and underwent hemiarthroplasty. Pathological examination of the pathological fracture site revealed no residual tumor tissue. |
| format | Article |
| id | doaj-art-82035375c6f248af85eb47d25b4c81fa |
| institution | Kabale University |
| issn | 2090-6978 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-82035375c6f248af85eb47d25b4c81fa2025-02-03T06:15:14ZengWileyCase Reports in Urology2090-69782024-01-01202410.1155/2024/7525757Bladder Cancer Invading the Prostate and Penis and Multiple Bone Metastases Showing Significant Improvement after a Short-Term Pembrolizumab Therapy following Radiation and Gemcitabine and Cisplatin Therapy Leading to a Pathologically Complete RemissionKyohei Ishida0Akira Ogose1Gen Kawaguchi2Go Hasegawa3Yohei Ikeda4Noboru Hara5Tsutomu Nishiyama6Department of UrologyDepartment of Orthopedic SurgeryDepartment of RadiotherapyDepartment of PathologyDepartment of Diagnostic RadiologyDepartment of UrologyDepartment of UrologyA 65-year-old man was diagnosed with bladder cancer invading the prostate and penis and multiple bone metastases. He underwent palliative radiation (30 Gy/10 fr) through vertebral bones (Th3 and Th12-L5) and pelvic bones for pain control. The patient received pembrolizumab therapy after three courses of gemcitabine and cisplatin therapy. CT four weeks after starting pembrolizumab therapy showed that both the primary and metastatic lesions had notably reduced in size, and no new lesion was detected. He subsequently fell, resulting in a femoral neck pathological fracture, and underwent hemiarthroplasty. Pathological examination of the pathological fracture site revealed no residual tumor tissue.http://dx.doi.org/10.1155/2024/7525757 |
| spellingShingle | Kyohei Ishida Akira Ogose Gen Kawaguchi Go Hasegawa Yohei Ikeda Noboru Hara Tsutomu Nishiyama Bladder Cancer Invading the Prostate and Penis and Multiple Bone Metastases Showing Significant Improvement after a Short-Term Pembrolizumab Therapy following Radiation and Gemcitabine and Cisplatin Therapy Leading to a Pathologically Complete Remission Case Reports in Urology |
| title | Bladder Cancer Invading the Prostate and Penis and Multiple Bone Metastases Showing Significant Improvement after a Short-Term Pembrolizumab Therapy following Radiation and Gemcitabine and Cisplatin Therapy Leading to a Pathologically Complete Remission |
| title_full | Bladder Cancer Invading the Prostate and Penis and Multiple Bone Metastases Showing Significant Improvement after a Short-Term Pembrolizumab Therapy following Radiation and Gemcitabine and Cisplatin Therapy Leading to a Pathologically Complete Remission |
| title_fullStr | Bladder Cancer Invading the Prostate and Penis and Multiple Bone Metastases Showing Significant Improvement after a Short-Term Pembrolizumab Therapy following Radiation and Gemcitabine and Cisplatin Therapy Leading to a Pathologically Complete Remission |
| title_full_unstemmed | Bladder Cancer Invading the Prostate and Penis and Multiple Bone Metastases Showing Significant Improvement after a Short-Term Pembrolizumab Therapy following Radiation and Gemcitabine and Cisplatin Therapy Leading to a Pathologically Complete Remission |
| title_short | Bladder Cancer Invading the Prostate and Penis and Multiple Bone Metastases Showing Significant Improvement after a Short-Term Pembrolizumab Therapy following Radiation and Gemcitabine and Cisplatin Therapy Leading to a Pathologically Complete Remission |
| title_sort | bladder cancer invading the prostate and penis and multiple bone metastases showing significant improvement after a short term pembrolizumab therapy following radiation and gemcitabine and cisplatin therapy leading to a pathologically complete remission |
| url | http://dx.doi.org/10.1155/2024/7525757 |
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