Shedding light on vascular imaging: the revolutionary role of nanotechnology
Abstract Vascular dysfunction, characterized by changes in anatomy, hemodynamics, and molecular expressions of vasculatures, is closely linked to the onset and development of diseases, emphasizing the importance of its detection. In clinical practice, medical imaging has been utilized as a significa...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-024-03042-x |
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| author | Peisen Zhang Yao Li Xiaoqi Li Yudong Wang Hua Lin Ni Zhang Wenyue Li Lihong Jing Mingxia Jiao Xiliang Luo Yi Hou |
| author_facet | Peisen Zhang Yao Li Xiaoqi Li Yudong Wang Hua Lin Ni Zhang Wenyue Li Lihong Jing Mingxia Jiao Xiliang Luo Yi Hou |
| author_sort | Peisen Zhang |
| collection | DOAJ |
| description | Abstract Vascular dysfunction, characterized by changes in anatomy, hemodynamics, and molecular expressions of vasculatures, is closely linked to the onset and development of diseases, emphasizing the importance of its detection. In clinical practice, medical imaging has been utilized as a significant tool in the assessment of vascular dysfunction, however, traditional imaging techniques still lack sufficient resolution for visualizing the complex microvascular systems. Over the past decade, with the rapid advancement of nanotechnology and the emergence of corresponding detection facilities, engineered nanomaterials offer new alternatives to traditional contrast agents. Compared with conventional small molecule counterparts, nanomaterials possess numerous advantages for vascular imaging, holding the potential to significantly advance related technologies. In this review, the latest developments in nanotechnology-assisted vascular imaging research across different imaging modalities, including contrast-enhanced magnetic resonance (MR) angiography, susceptibility-weighted imaging (SWI), and fluorescence imaging in the second near-infrared window (NIR-II) are summarized. Additionally, the advancements of preclinical and clinical studies related to these nanotechnology-enhanced vascular imaging approaches are outlined, with subsequent discussion on the current challenges and future prospects in both basic research and clinical translation. Graphical Abstract |
| format | Article |
| id | doaj-art-81fdd75c87384c9bb8c5a004dfe44bcc |
| institution | DOAJ |
| issn | 1477-3155 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-81fdd75c87384c9bb8c5a004dfe44bcc2025-08-20T02:39:41ZengBMCJournal of Nanobiotechnology1477-31552024-12-0122112310.1186/s12951-024-03042-xShedding light on vascular imaging: the revolutionary role of nanotechnologyPeisen Zhang0Yao Li1Xiaoqi Li2Yudong Wang3Hua Lin4Ni Zhang5Wenyue Li6Lihong Jing7Mingxia Jiao8Xiliang Luo9Yi Hou10Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and TechnologyKey Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and TechnologyKey Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and TechnologyKey Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and TechnologyDepartment of Psychiatry, West China Hospital of Sichuan UniversityDepartment of Psychiatry, West China Hospital of Sichuan UniversityCollege of Life Science and Technology, Beijing University of Chemical TechnologyBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid and Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Center for Carbon Neutral Chemistry, Institute of Chemistry, Chinese Academy of SciencesKey Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and TechnologyKey Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and TechnologyCollege of Life Science and Technology, Beijing University of Chemical TechnologyAbstract Vascular dysfunction, characterized by changes in anatomy, hemodynamics, and molecular expressions of vasculatures, is closely linked to the onset and development of diseases, emphasizing the importance of its detection. In clinical practice, medical imaging has been utilized as a significant tool in the assessment of vascular dysfunction, however, traditional imaging techniques still lack sufficient resolution for visualizing the complex microvascular systems. Over the past decade, with the rapid advancement of nanotechnology and the emergence of corresponding detection facilities, engineered nanomaterials offer new alternatives to traditional contrast agents. Compared with conventional small molecule counterparts, nanomaterials possess numerous advantages for vascular imaging, holding the potential to significantly advance related technologies. In this review, the latest developments in nanotechnology-assisted vascular imaging research across different imaging modalities, including contrast-enhanced magnetic resonance (MR) angiography, susceptibility-weighted imaging (SWI), and fluorescence imaging in the second near-infrared window (NIR-II) are summarized. Additionally, the advancements of preclinical and clinical studies related to these nanotechnology-enhanced vascular imaging approaches are outlined, with subsequent discussion on the current challenges and future prospects in both basic research and clinical translation. Graphical Abstracthttps://doi.org/10.1186/s12951-024-03042-xVascular dysfunctionNanomaterialsMR angiographySusceptibility-weighted imagingFluorescence imaging |
| spellingShingle | Peisen Zhang Yao Li Xiaoqi Li Yudong Wang Hua Lin Ni Zhang Wenyue Li Lihong Jing Mingxia Jiao Xiliang Luo Yi Hou Shedding light on vascular imaging: the revolutionary role of nanotechnology Journal of Nanobiotechnology Vascular dysfunction Nanomaterials MR angiography Susceptibility-weighted imaging Fluorescence imaging |
| title | Shedding light on vascular imaging: the revolutionary role of nanotechnology |
| title_full | Shedding light on vascular imaging: the revolutionary role of nanotechnology |
| title_fullStr | Shedding light on vascular imaging: the revolutionary role of nanotechnology |
| title_full_unstemmed | Shedding light on vascular imaging: the revolutionary role of nanotechnology |
| title_short | Shedding light on vascular imaging: the revolutionary role of nanotechnology |
| title_sort | shedding light on vascular imaging the revolutionary role of nanotechnology |
| topic | Vascular dysfunction Nanomaterials MR angiography Susceptibility-weighted imaging Fluorescence imaging |
| url | https://doi.org/10.1186/s12951-024-03042-x |
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