LPA Promotes T Cell Recruitment through Synthesis of CXCL13
Lysophosphatidic acid (LPA) is a bioactive phospholipid playing an important role in various inflammatory diseases by inducing expression and secretion of many inflammatory cytokines/chemokines. Here we report in a murine air pouch model of inflammation that LPA induced CXCL13 secretion in a time-de...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/248492 |
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| _version_ | 1832553478154616832 |
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| author | Weili Hui Chenqi Zhao Sylvain G. Bourgoin |
| author_facet | Weili Hui Chenqi Zhao Sylvain G. Bourgoin |
| author_sort | Weili Hui |
| collection | DOAJ |
| description | Lysophosphatidic acid (LPA) is a bioactive phospholipid playing an important role in various inflammatory diseases by inducing expression and secretion of many inflammatory cytokines/chemokines. Here we report in a murine air pouch model of inflammation that LPA induced CXCL13 secretion in a time-dependent manner and with exacerbation of the response when LPA was administered after a pretreatment with TNF-α, a key inflammatory cytokine. LPA mediates recruitment of leukocytes, including that of CD3+ cells into unprimed and TNF-α-primed air pouches. CXCL13 neutralization using a blocking antibody injected into air pouches prior to administration of LPA into TNF-α-primed air pouches decreased CD3+ cell influx. Our data highlight that LPA-mediated CXCL13 secretion plays a role in T cell recruitment and participates in regulation of the inflammatory response. |
| format | Article |
| id | doaj-art-81fc8c6568454da1bb8ff8cc78f0340c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-81fc8c6568454da1bb8ff8cc78f0340c2025-02-03T05:53:50ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/248492248492LPA Promotes T Cell Recruitment through Synthesis of CXCL13Weili Hui0Chenqi Zhao1Sylvain G. Bourgoin2Rheumatology and Immunology Research Center, CHU de Québec Research Center and Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Québec, QC, G1V 4G2, CanadaRheumatology and Immunology Research Center, CHU de Québec Research Center and Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Québec, QC, G1V 4G2, CanadaRheumatology and Immunology Research Center, CHU de Québec Research Center and Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Québec, QC, G1V 4G2, CanadaLysophosphatidic acid (LPA) is a bioactive phospholipid playing an important role in various inflammatory diseases by inducing expression and secretion of many inflammatory cytokines/chemokines. Here we report in a murine air pouch model of inflammation that LPA induced CXCL13 secretion in a time-dependent manner and with exacerbation of the response when LPA was administered after a pretreatment with TNF-α, a key inflammatory cytokine. LPA mediates recruitment of leukocytes, including that of CD3+ cells into unprimed and TNF-α-primed air pouches. CXCL13 neutralization using a blocking antibody injected into air pouches prior to administration of LPA into TNF-α-primed air pouches decreased CD3+ cell influx. Our data highlight that LPA-mediated CXCL13 secretion plays a role in T cell recruitment and participates in regulation of the inflammatory response.http://dx.doi.org/10.1155/2015/248492 |
| spellingShingle | Weili Hui Chenqi Zhao Sylvain G. Bourgoin LPA Promotes T Cell Recruitment through Synthesis of CXCL13 Mediators of Inflammation |
| title | LPA Promotes T Cell Recruitment through Synthesis of CXCL13 |
| title_full | LPA Promotes T Cell Recruitment through Synthesis of CXCL13 |
| title_fullStr | LPA Promotes T Cell Recruitment through Synthesis of CXCL13 |
| title_full_unstemmed | LPA Promotes T Cell Recruitment through Synthesis of CXCL13 |
| title_short | LPA Promotes T Cell Recruitment through Synthesis of CXCL13 |
| title_sort | lpa promotes t cell recruitment through synthesis of cxcl13 |
| url | http://dx.doi.org/10.1155/2015/248492 |
| work_keys_str_mv | AT weilihui lpapromotestcellrecruitmentthroughsynthesisofcxcl13 AT chenqizhao lpapromotestcellrecruitmentthroughsynthesisofcxcl13 AT sylvaingbourgoin lpapromotestcellrecruitmentthroughsynthesisofcxcl13 |