The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis
Based upon our morphologic observations, we hypothesize and also provide morphometric evidence for the occurrence of progressive developmental changes in many uterine fibroids, which can be arbitrarily divided into 4 phases. These developmental phases are related to the ongoing production of extrace...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2013/285103 |
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| author | Gordon P. Flake Alicia B. Moore Norris Flagler Benita Wicker Natasha Clayton Grace E. Kissling Stanley J. Robboy Darlene Dixon |
| author_facet | Gordon P. Flake Alicia B. Moore Norris Flagler Benita Wicker Natasha Clayton Grace E. Kissling Stanley J. Robboy Darlene Dixon |
| author_sort | Gordon P. Flake |
| collection | DOAJ |
| description | Based upon our morphologic observations, we hypothesize and also provide morphometric evidence for the occurrence of progressive developmental changes in many uterine fibroids, which can be arbitrarily divided into 4 phases. These developmental phases are related to the ongoing production of extracellular collagenous matrix, which eventually exceeds the degree of angiogenesis, resulting in the progressive separation of myocytes from their blood supply and a condition of interstitial ischemia. The consequence of this process of slow ischemia with nutritional and oxygen deprivation is a progressive myocyte atrophy (or inanition), culminating in cell death, a process that we refer to as inanosis. The studies presented here provide quantitative and semiquantitative evidence to support the concept of the declining proliferative activity as the collagenous matrix increases and the microvascular density decreases. |
| format | Article |
| id | doaj-art-81f91297bf054b409edaca5bf1705c4c |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-81f91297bf054b409edaca5bf1705c4c2025-02-03T01:01:50ZengWileyObstetrics and Gynecology International1687-95891687-95972013-01-01201310.1155/2013/285103285103The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and InanosisGordon P. Flake0Alicia B. Moore1Norris Flagler2Benita Wicker3Natasha Clayton4Grace E. Kissling5Stanley J. Robboy6Darlene Dixon7Cellular and Molecular Pathology Branch, National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services, Research Triangle Park, NC 27709, USAMolecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services, Research Triangle Park, NC 27709, USACellular and Molecular Pathology Branch, National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services, Research Triangle Park, NC 27709, USACellular and Molecular Pathology Branch, National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services, Research Triangle Park, NC 27709, USACellular and Molecular Pathology Branch, National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services, Research Triangle Park, NC 27709, USABiostatistics Branch, Division of Intramural Research, National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services, Research Triangle Park, NC 27709, USADepartment of Pathology, Duke University Medical Center, Durham, NC 27710, USAMolecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services, Research Triangle Park, NC 27709, USABased upon our morphologic observations, we hypothesize and also provide morphometric evidence for the occurrence of progressive developmental changes in many uterine fibroids, which can be arbitrarily divided into 4 phases. These developmental phases are related to the ongoing production of extracellular collagenous matrix, which eventually exceeds the degree of angiogenesis, resulting in the progressive separation of myocytes from their blood supply and a condition of interstitial ischemia. The consequence of this process of slow ischemia with nutritional and oxygen deprivation is a progressive myocyte atrophy (or inanition), culminating in cell death, a process that we refer to as inanosis. The studies presented here provide quantitative and semiquantitative evidence to support the concept of the declining proliferative activity as the collagenous matrix increases and the microvascular density decreases.http://dx.doi.org/10.1155/2013/285103 |
| spellingShingle | Gordon P. Flake Alicia B. Moore Norris Flagler Benita Wicker Natasha Clayton Grace E. Kissling Stanley J. Robboy Darlene Dixon The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis Obstetrics and Gynecology International |
| title | The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis |
| title_full | The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis |
| title_fullStr | The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis |
| title_full_unstemmed | The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis |
| title_short | The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis |
| title_sort | natural history of uterine leiomyomas morphometric concordance with concepts of interstitial ischemia and inanosis |
| url | http://dx.doi.org/10.1155/2013/285103 |
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