Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study
Abstract This study evaluated the impact of aspirin on the biochemical recurrence (BCR) rate following robot-assisted radical prostatectomy (RARP) in patients. A database search identified patients who underwent RARP for pT2-3N0M0 disease at any of 25 centers between 2011 and 2022, categorized into...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86521-x |
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| author | Shuhei Suzuki Hiromitsu Negoro Masashi Kubota Takayuki Sumiyoshi Ryoichi Saito Tomoya Okuno Takehiko Segawa Shigeki Fukuzawa Hiroyuki Onishi Kodai Hattahara Kanji Nagahama Yuya Sekine Ryoma Kurahashi Kimihiro Shimatani Atsuro Sawada Shusuke Akamatsu Hiroyuki Nishiyama Takayuki Goto Takashi Kobayashi |
| author_facet | Shuhei Suzuki Hiromitsu Negoro Masashi Kubota Takayuki Sumiyoshi Ryoichi Saito Tomoya Okuno Takehiko Segawa Shigeki Fukuzawa Hiroyuki Onishi Kodai Hattahara Kanji Nagahama Yuya Sekine Ryoma Kurahashi Kimihiro Shimatani Atsuro Sawada Shusuke Akamatsu Hiroyuki Nishiyama Takayuki Goto Takashi Kobayashi |
| author_sort | Shuhei Suzuki |
| collection | DOAJ |
| description | Abstract This study evaluated the impact of aspirin on the biochemical recurrence (BCR) rate following robot-assisted radical prostatectomy (RARP) in patients. A database search identified patients who underwent RARP for pT2-3N0M0 disease at any of 25 centers between 2011 and 2022, categorized into aspirin (n = 350) and control groups (n = 5857). Adjustment by 1:1 propensity score matching (PSM) and Mahalanobis distance matching (MDM) created 350 matched pairs. The effect of aspirin on the BCR rate was evaluated by analysis of BCR-free survival. After PSM and MDM, the 3-year BCR-free rate was significantly better in the aspirin group (85.0%, 95% confidence interval [CI] 80.8–89.4) than in the control group (PSM, 74.5%, 95% CI 66.5–83.5, p = 0.021; MDM, 74.7%, 95% CI 66.3–84.3, p = 0.037). In the analysis of high-risk subgroups, patients in the aspirin group with an ISUP (International Society of Urological Pathology) grade ≥ 4 had a significantly lower recurrence rate in both matched groups (PSM, hazard ratio 0.44, 95% CI 0.22–0.88; MDM, hazard ratio 0.45, 95% CI 0.23–0.90). In conclusion, this study suggests that aspirin could enhance BCR-free survival post-RARP, especially in patients with higher ISUP grades. |
| format | Article |
| id | doaj-art-81f170640e5b4b9380232d3056dc1380 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-81f170640e5b4b9380232d3056dc13802025-01-19T12:21:39ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-86521-xImpact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort studyShuhei Suzuki0Hiromitsu Negoro1Masashi Kubota2Takayuki Sumiyoshi3Ryoichi Saito4Tomoya Okuno5Takehiko Segawa6Shigeki Fukuzawa7Hiroyuki Onishi8Kodai Hattahara9Kanji Nagahama10Yuya Sekine11Ryoma Kurahashi12Kimihiro Shimatani13Atsuro Sawada14Shusuke Akamatsu15Hiroyuki Nishiyama16Takayuki Goto17Takashi Kobayashi18Department of Urology, University of TsukubaDepartment of Urology, University of TsukubaDepartment of Urology, Kyoto University School of MedicineDepartment of Urology, Kyoto University School of MedicineDepartment of Urology, Kyoto University School of MedicineDepartment of Urology and Retroperitoneal Surgery, National Cancer Center HospitalDepartment of Urology, Kyoto City HospitalDepartment of Urology, Shimada General Medical CenterDepartment of Urology, Japanese Red Cross Osaka HospitalDepartment of Urology, Shiga General HospitalDepartment of Urology, Rakuwakai Otowa HospitalDepartment of Urology, Akita University Graduate School of MedicineDepartment of Urology, Faculty of Life Sciences, Kumamoto UniversityDepartment of Urology, Hyogo Medical UniversityDepartment of Urology, Miyazaki UniversityDepartment of Urology, Nagoya UniversityDepartment of Urology, University of TsukubaDepartment of Urology, Kyoto University School of MedicineDepartment of Urology, Kyoto University School of MedicineAbstract This study evaluated the impact of aspirin on the biochemical recurrence (BCR) rate following robot-assisted radical prostatectomy (RARP) in patients. A database search identified patients who underwent RARP for pT2-3N0M0 disease at any of 25 centers between 2011 and 2022, categorized into aspirin (n = 350) and control groups (n = 5857). Adjustment by 1:1 propensity score matching (PSM) and Mahalanobis distance matching (MDM) created 350 matched pairs. The effect of aspirin on the BCR rate was evaluated by analysis of BCR-free survival. After PSM and MDM, the 3-year BCR-free rate was significantly better in the aspirin group (85.0%, 95% confidence interval [CI] 80.8–89.4) than in the control group (PSM, 74.5%, 95% CI 66.5–83.5, p = 0.021; MDM, 74.7%, 95% CI 66.3–84.3, p = 0.037). In the analysis of high-risk subgroups, patients in the aspirin group with an ISUP (International Society of Urological Pathology) grade ≥ 4 had a significantly lower recurrence rate in both matched groups (PSM, hazard ratio 0.44, 95% CI 0.22–0.88; MDM, hazard ratio 0.45, 95% CI 0.23–0.90). In conclusion, this study suggests that aspirin could enhance BCR-free survival post-RARP, especially in patients with higher ISUP grades.https://doi.org/10.1038/s41598-025-86521-xAspirinBiochemical recurrenceProstate cancerRobot-assisted laparoscopic radical prostatectomySurvival rate |
| spellingShingle | Shuhei Suzuki Hiromitsu Negoro Masashi Kubota Takayuki Sumiyoshi Ryoichi Saito Tomoya Okuno Takehiko Segawa Shigeki Fukuzawa Hiroyuki Onishi Kodai Hattahara Kanji Nagahama Yuya Sekine Ryoma Kurahashi Kimihiro Shimatani Atsuro Sawada Shusuke Akamatsu Hiroyuki Nishiyama Takayuki Goto Takashi Kobayashi Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study Scientific Reports Aspirin Biochemical recurrence Prostate cancer Robot-assisted laparoscopic radical prostatectomy Survival rate |
| title | Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study |
| title_full | Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study |
| title_fullStr | Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study |
| title_full_unstemmed | Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study |
| title_short | Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study |
| title_sort | impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study |
| topic | Aspirin Biochemical recurrence Prostate cancer Robot-assisted laparoscopic radical prostatectomy Survival rate |
| url | https://doi.org/10.1038/s41598-025-86521-x |
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