Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model
Background. The deterioration of hemodynamics instantly endangers the patients’ life after polytrauma. As accidental hypothermia frequently occurs in polytrauma, therapeutic hypothermia still displays an ambivalent role as the impact on the cardiopulmonary function is not yet fully understood. Metho...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/829195 |
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| author | Matthias Weuster Philipp Mommsen Roman Pfeifer Juliane Mohr Steffen Ruchholtz Sascha Flohé Matthias Fröhlich Claudia Keibl Andreas Seekamp Martijn van Griensven Ingo Witte |
| author_facet | Matthias Weuster Philipp Mommsen Roman Pfeifer Juliane Mohr Steffen Ruchholtz Sascha Flohé Matthias Fröhlich Claudia Keibl Andreas Seekamp Martijn van Griensven Ingo Witte |
| author_sort | Matthias Weuster |
| collection | DOAJ |
| description | Background. The deterioration of hemodynamics instantly endangers the patients’ life after polytrauma. As accidental hypothermia frequently occurs in polytrauma, therapeutic hypothermia still displays an ambivalent role as the impact on the cardiopulmonary function is not yet fully understood. Methods. We have previously established a porcine polytrauma model including blunt chest trauma, penetrating abdominal trauma, and hemorrhagic shock. Therapeutic hypothermia (34°C) was induced for 3 hours. We documented cardiovascular parameters and basic respiratory parameters. Pigs were euthanized after 15.5 hours. Results. Our polytrauma porcine model displayed sufficient trauma impact. Resuscitation showed adequate restoration of hemodynamics. Induced hypothermia had neither harmful nor major positive effects on the animals’ hemodynamics. Though heart rate significantly decreased and mixed venous oxygen saturation significantly increased during therapeutic hypothermia. Mean arterial blood pressure, central venous pressure, pulmonary arterial pressure, and wedge pressure showed no significant differences comparing normothermic trauma and hypothermic trauma pigs during hypothermia. Conclusions. Induced hypothermia after polytrauma is feasible. No major harmful effects on hemodynamics were observed. Therapeutic hypothermia revealed hints for tissue protective impact. But the chosen length for therapeutic hypothermia was too short. Nevertheless, therapeutic hypothermia might be a useful tool for intensive care after polytrauma. Future studies should extend therapeutic hypothermia. |
| format | Article |
| id | doaj-art-81e895caea3b4a27990bad9c8d44e8d1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-81e895caea3b4a27990bad9c8d44e8d12025-02-03T01:30:38ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/829195829195Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine ModelMatthias Weuster0Philipp Mommsen1Roman Pfeifer2Juliane Mohr3Steffen Ruchholtz4Sascha Flohé5Matthias Fröhlich6Claudia Keibl7Andreas Seekamp8Martijn van Griensven9Ingo Witte10Department of Trauma Surgery, University of Schleswig-Holstein, 24105 Kiel, GermanyDepartment of Trauma Surgery, Hannover Medical School, 30625 Hannover, GermanyDepartment of Trauma Surgery, University of Aachen, 52074 Aachen, GermanyDepartment of Trauma Surgery, University of Marburg-Giessen, 35043 Marburg, GermanyDepartment of Trauma Surgery, University of Marburg-Giessen, 35043 Marburg, GermanyDepartment of Trauma Surgery, University of Düsseldorf, 40225 Düsseldorf, GermanyDepartment of Trauma Surgery, University of Aachen, 52074 Aachen, GermanyLudwig Boltzmann Institute for Experimental and Clinical Traumatology, 1200 Vienna, AustriaDepartment of Trauma Surgery, University of Schleswig-Holstein, 24105 Kiel, GermanyLudwig Boltzmann Institute for Experimental and Clinical Traumatology, 1200 Vienna, AustriaDepartment of Trauma Surgery, University of Düsseldorf, 40225 Düsseldorf, GermanyBackground. The deterioration of hemodynamics instantly endangers the patients’ life after polytrauma. As accidental hypothermia frequently occurs in polytrauma, therapeutic hypothermia still displays an ambivalent role as the impact on the cardiopulmonary function is not yet fully understood. Methods. We have previously established a porcine polytrauma model including blunt chest trauma, penetrating abdominal trauma, and hemorrhagic shock. Therapeutic hypothermia (34°C) was induced for 3 hours. We documented cardiovascular parameters and basic respiratory parameters. Pigs were euthanized after 15.5 hours. Results. Our polytrauma porcine model displayed sufficient trauma impact. Resuscitation showed adequate restoration of hemodynamics. Induced hypothermia had neither harmful nor major positive effects on the animals’ hemodynamics. Though heart rate significantly decreased and mixed venous oxygen saturation significantly increased during therapeutic hypothermia. Mean arterial blood pressure, central venous pressure, pulmonary arterial pressure, and wedge pressure showed no significant differences comparing normothermic trauma and hypothermic trauma pigs during hypothermia. Conclusions. Induced hypothermia after polytrauma is feasible. No major harmful effects on hemodynamics were observed. Therapeutic hypothermia revealed hints for tissue protective impact. But the chosen length for therapeutic hypothermia was too short. Nevertheless, therapeutic hypothermia might be a useful tool for intensive care after polytrauma. Future studies should extend therapeutic hypothermia.http://dx.doi.org/10.1155/2015/829195 |
| spellingShingle | Matthias Weuster Philipp Mommsen Roman Pfeifer Juliane Mohr Steffen Ruchholtz Sascha Flohé Matthias Fröhlich Claudia Keibl Andreas Seekamp Martijn van Griensven Ingo Witte Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model Mediators of Inflammation |
| title | Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model |
| title_full | Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model |
| title_fullStr | Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model |
| title_full_unstemmed | Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model |
| title_short | Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model |
| title_sort | induced hypothermia does not harm hemodynamics after polytrauma a porcine model |
| url | http://dx.doi.org/10.1155/2015/829195 |
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