Digital humanistic program to manage premature frailty in young breast cancer survivors with gender perspective
Abstract Premature frailty is a critical challenge for young breast cancer survivors (YBCSs), impacting their health and perpetuating gender inequality through heightened vulnerability and marginalization. While digital health shows promise in frailty screening, its effectiveness for comprehensively...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Digital Medicine |
| Online Access: | https://doi.org/10.1038/s41746-025-01439-y |
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| author | Yun Hu Joshua Wiley Lulu Jiang Xiyi Wang Ran Yi Jiehui Xu Yanyan Liu Aozhou Weng Futai Zou Eun-Ok Im |
| author_facet | Yun Hu Joshua Wiley Lulu Jiang Xiyi Wang Ran Yi Jiehui Xu Yanyan Liu Aozhou Weng Futai Zou Eun-Ok Im |
| author_sort | Yun Hu |
| collection | DOAJ |
| description | Abstract Premature frailty is a critical challenge for young breast cancer survivors (YBCSs), impacting their health and perpetuating gender inequality through heightened vulnerability and marginalization. While digital health shows promise in frailty screening, its effectiveness for comprehensively managing frailty remains inconclusive. This randomized controlled trial, registered at the Chinese Clinical Trial Registry (ChiCTR2200058823), tests the “AI-TA” program’s efficacy on premature frailty and quality of life in YBCSs. The intervention group received a gender- and generation-sensitive program combining artificial intelligence interactions and humanities skills. The control group received 12 weeks of online information support. Both groups improved in frailty dimensions (P < 0.05); the intervention group showed notable enhancements in psychological (P = 0.013) and social frailty (P < 0.001). Quality of life also improved more in the intervention group from T1 to T2 (β = 15.384, 95% CI:13.028–17.740, P < 0.001). Results show a gender- and generation-sensitive digital humanistic program can optimize frailty management, promoting survivorship and gender equity. |
| format | Article |
| id | doaj-art-81e5f62b5660469ab25354f818f5f9b7 |
| institution | Kabale University |
| issn | 2398-6352 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Digital Medicine |
| spelling | doaj-art-81e5f62b5660469ab25354f818f5f9b72025-01-19T12:39:45ZengNature Portfolionpj Digital Medicine2398-63522025-01-018111610.1038/s41746-025-01439-yDigital humanistic program to manage premature frailty in young breast cancer survivors with gender perspectiveYun Hu0Joshua Wiley1Lulu Jiang2Xiyi Wang3Ran Yi4Jiehui Xu5Yanyan Liu6Aozhou Weng7Futai Zou8Eun-Ok Im9School of Nursing, Shanghai Jiao Tong UniversityTurner Institute for Brain and Mental Health and School of Psychological Sciences, Monash UniversitySchool of Nursing, Shanghai Jiao Tong UniversitySchool of Nursing, Shanghai Jiao Tong UniversitySchool of Nursing, Shanghai Jiao Tong UniversityRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineSchool of Nursing, Shanghai Jiao Tong UniversitySchool of Nursing, Shanghai Jiao Tong UniversitySchool of Electronic Information and Electrical Engineering, Shanghai Jiao Tong UniversitySchool of Nursing, The University of Texas at AustinAbstract Premature frailty is a critical challenge for young breast cancer survivors (YBCSs), impacting their health and perpetuating gender inequality through heightened vulnerability and marginalization. While digital health shows promise in frailty screening, its effectiveness for comprehensively managing frailty remains inconclusive. This randomized controlled trial, registered at the Chinese Clinical Trial Registry (ChiCTR2200058823), tests the “AI-TA” program’s efficacy on premature frailty and quality of life in YBCSs. The intervention group received a gender- and generation-sensitive program combining artificial intelligence interactions and humanities skills. The control group received 12 weeks of online information support. Both groups improved in frailty dimensions (P < 0.05); the intervention group showed notable enhancements in psychological (P = 0.013) and social frailty (P < 0.001). Quality of life also improved more in the intervention group from T1 to T2 (β = 15.384, 95% CI:13.028–17.740, P < 0.001). Results show a gender- and generation-sensitive digital humanistic program can optimize frailty management, promoting survivorship and gender equity.https://doi.org/10.1038/s41746-025-01439-y |
| spellingShingle | Yun Hu Joshua Wiley Lulu Jiang Xiyi Wang Ran Yi Jiehui Xu Yanyan Liu Aozhou Weng Futai Zou Eun-Ok Im Digital humanistic program to manage premature frailty in young breast cancer survivors with gender perspective npj Digital Medicine |
| title | Digital humanistic program to manage premature frailty in young breast cancer survivors with gender perspective |
| title_full | Digital humanistic program to manage premature frailty in young breast cancer survivors with gender perspective |
| title_fullStr | Digital humanistic program to manage premature frailty in young breast cancer survivors with gender perspective |
| title_full_unstemmed | Digital humanistic program to manage premature frailty in young breast cancer survivors with gender perspective |
| title_short | Digital humanistic program to manage premature frailty in young breast cancer survivors with gender perspective |
| title_sort | digital humanistic program to manage premature frailty in young breast cancer survivors with gender perspective |
| url | https://doi.org/10.1038/s41746-025-01439-y |
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