Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations
Depressive and anxiety disorders are frequently observed in patients with Systemic Lupus Erythematosus (SLE). However, the underlying mechanisms are still unknown. We conducted this survey to understand the prevalence of depression and anxiety in SLE patients without major neuropsychiatric manifesta...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/2829018 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547444600078336 |
|---|---|
| author | Ru Bai Shuang Liu Yueyin Zhao Yuqi Cheng Shu Li Aiyun Lai Zhongqi Xie Xinyu Xu Zhaoping Lu Jian Xu |
| author_facet | Ru Bai Shuang Liu Yueyin Zhao Yuqi Cheng Shu Li Aiyun Lai Zhongqi Xie Xinyu Xu Zhaoping Lu Jian Xu |
| author_sort | Ru Bai |
| collection | DOAJ |
| description | Depressive and anxiety disorders are frequently observed in patients with Systemic Lupus Erythematosus (SLE). However, the underlying mechanisms are still unknown. We conducted this survey to understand the prevalence of depression and anxiety in SLE patients without major neuropsychiatric manifestations (non-NPSLE) and to explore the relationship between emotional disorders, symptoms, autoantibodies, disease activity, and treatments in SLE. 176 SLE patients were included, and SLE disease activity index (SLEDAI), Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Rating Scale (HAMA) were recorded to evaluate their disease activity and emotional status. We found that depressive and anxiety disorders were common among SLE patients: 121 (68.8%) patients were in depression status while 14 (8.0%) patients could be diagnosed with depression. Accordingly, 101 (57.4%) were in anxiety status and 21 (11.9%) could be diagnosed with anxiety. Depression was associated with disease activity, and anxiety was associated with anti-P0 antibody, while both of them were associated with proteinuria. HAMA and HAMD scores were in strong positive correlation and they were independent risk factors of each other. We concluded that the high prevalence of depression and anxiety and the association between depression and SLE disease activity might reveal the covert damage of central nervous system in SLE. The role of anti-P0 antibody in SLE patients with emotional disorders warrants more researches. |
| format | Article |
| id | doaj-art-81da88a8dde34281852fbfdfae030f87 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-81da88a8dde34281852fbfdfae030f872025-02-03T06:44:40ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/28290182829018Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric ManifestationsRu Bai0Shuang Liu1Yueyin Zhao2Yuqi Cheng3Shu Li4Aiyun Lai5Zhongqi Xie6Xinyu Xu7Zhaoping Lu8Jian Xu9Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepressive and anxiety disorders are frequently observed in patients with Systemic Lupus Erythematosus (SLE). However, the underlying mechanisms are still unknown. We conducted this survey to understand the prevalence of depression and anxiety in SLE patients without major neuropsychiatric manifestations (non-NPSLE) and to explore the relationship between emotional disorders, symptoms, autoantibodies, disease activity, and treatments in SLE. 176 SLE patients were included, and SLE disease activity index (SLEDAI), Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Rating Scale (HAMA) were recorded to evaluate their disease activity and emotional status. We found that depressive and anxiety disorders were common among SLE patients: 121 (68.8%) patients were in depression status while 14 (8.0%) patients could be diagnosed with depression. Accordingly, 101 (57.4%) were in anxiety status and 21 (11.9%) could be diagnosed with anxiety. Depression was associated with disease activity, and anxiety was associated with anti-P0 antibody, while both of them were associated with proteinuria. HAMA and HAMD scores were in strong positive correlation and they were independent risk factors of each other. We concluded that the high prevalence of depression and anxiety and the association between depression and SLE disease activity might reveal the covert damage of central nervous system in SLE. The role of anti-P0 antibody in SLE patients with emotional disorders warrants more researches.http://dx.doi.org/10.1155/2016/2829018 |
| spellingShingle | Ru Bai Shuang Liu Yueyin Zhao Yuqi Cheng Shu Li Aiyun Lai Zhongqi Xie Xinyu Xu Zhaoping Lu Jian Xu Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations Journal of Immunology Research |
| title | Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations |
| title_full | Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations |
| title_fullStr | Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations |
| title_full_unstemmed | Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations |
| title_short | Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations |
| title_sort | depressive and anxiety disorders in systemic lupus erythematosus patients without major neuropsychiatric manifestations |
| url | http://dx.doi.org/10.1155/2016/2829018 |
| work_keys_str_mv | AT rubai depressiveandanxietydisordersinsystemiclupuserythematosuspatientswithoutmajorneuropsychiatricmanifestations AT shuangliu depressiveandanxietydisordersinsystemiclupuserythematosuspatientswithoutmajorneuropsychiatricmanifestations AT yueyinzhao depressiveandanxietydisordersinsystemiclupuserythematosuspatientswithoutmajorneuropsychiatricmanifestations AT yuqicheng depressiveandanxietydisordersinsystemiclupuserythematosuspatientswithoutmajorneuropsychiatricmanifestations AT shuli depressiveandanxietydisordersinsystemiclupuserythematosuspatientswithoutmajorneuropsychiatricmanifestations AT aiyunlai depressiveandanxietydisordersinsystemiclupuserythematosuspatientswithoutmajorneuropsychiatricmanifestations AT zhongqixie depressiveandanxietydisordersinsystemiclupuserythematosuspatientswithoutmajorneuropsychiatricmanifestations AT xinyuxu depressiveandanxietydisordersinsystemiclupuserythematosuspatientswithoutmajorneuropsychiatricmanifestations AT zhaopinglu depressiveandanxietydisordersinsystemiclupuserythematosuspatientswithoutmajorneuropsychiatricmanifestations AT jianxu depressiveandanxietydisordersinsystemiclupuserythematosuspatientswithoutmajorneuropsychiatricmanifestations |