Molecular Nevogenesis
Despite recent advances, the biology underlying nevogenesis remains unclear. Activating mutations in NRAS, HRAS, BRAF, and GNAQ have been identified in benign nevi. Their presence roughly correlates with congenital, Spitz, acquired, and blue nevi, respectively. These mutations are likely to play...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2011/463184 |
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| _version_ | 1849409720126799872 |
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| author | Andrew L. Ross Margaret I. Sanchez James M. Grichnik |
| author_facet | Andrew L. Ross Margaret I. Sanchez James M. Grichnik |
| author_sort | Andrew L. Ross |
| collection | DOAJ |
| description | Despite recent advances, the biology underlying nevogenesis remains unclear. Activating mutations in NRAS, HRAS, BRAF, and GNAQ have been identified in benign nevi. Their presence roughly correlates with congenital, Spitz, acquired, and blue nevi, respectively. These mutations are likely to play a critical role in driving nevogenesis. While each mutation is able to activate the MAP kinase pathway, they also interact with a host of different proteins in other pathways. The different melanocytic developmental pathways activated by each mutation cause the cells to migrate, proliferate, and differentiate to different extents within the skin. This causes each mutation to give rise to a characteristic growth pattern. The exact location and differentiation state of the cell of origin for benign moles remains to be discovered. Further research is necessary to fully understand nevus development given that most of the same developmental pathways are also present in melanoma. |
| format | Article |
| id | doaj-art-81d3ec33fa664bc394034dc80d4e6e25 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-81d3ec33fa664bc394034dc80d4e6e252025-08-20T03:35:24ZengWileyDermatology Research and Practice1687-61051687-61132011-01-01201110.1155/2011/463184463184Molecular NevogenesisAndrew L. Ross0Margaret I. Sanchez1James M. Grichnik2Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADespite recent advances, the biology underlying nevogenesis remains unclear. Activating mutations in NRAS, HRAS, BRAF, and GNAQ have been identified in benign nevi. Their presence roughly correlates with congenital, Spitz, acquired, and blue nevi, respectively. These mutations are likely to play a critical role in driving nevogenesis. While each mutation is able to activate the MAP kinase pathway, they also interact with a host of different proteins in other pathways. The different melanocytic developmental pathways activated by each mutation cause the cells to migrate, proliferate, and differentiate to different extents within the skin. This causes each mutation to give rise to a characteristic growth pattern. The exact location and differentiation state of the cell of origin for benign moles remains to be discovered. Further research is necessary to fully understand nevus development given that most of the same developmental pathways are also present in melanoma.http://dx.doi.org/10.1155/2011/463184 |
| spellingShingle | Andrew L. Ross Margaret I. Sanchez James M. Grichnik Molecular Nevogenesis Dermatology Research and Practice |
| title | Molecular Nevogenesis |
| title_full | Molecular Nevogenesis |
| title_fullStr | Molecular Nevogenesis |
| title_full_unstemmed | Molecular Nevogenesis |
| title_short | Molecular Nevogenesis |
| title_sort | molecular nevogenesis |
| url | http://dx.doi.org/10.1155/2011/463184 |
| work_keys_str_mv | AT andrewlross molecularnevogenesis AT margaretisanchez molecularnevogenesis AT jamesmgrichnik molecularnevogenesis |