ClpB chaperone as a promising target for antimicrobial therapy: A narrative review
The Clp/Hsp100 family, part of the ATPase associated with various cellular activities (AAA+) superfamily, includes caseinolytic peptidase B (ClpB), a highly conserved protein found in bacteria, fungi, protozoa, and plants. Notably, ClpB is present in all ESKAPE pathogens: Enterococcus faecium, Staph...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
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| Online Access: | https://journals.lww.com/10.4103/apjtb.apjtb_590_24 |
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| author | Sachini J. Udari Sayoka Shamodhi Rumesh M. Nelumdeniya Udayana Ranatunga Nimesha N. Senadeera Chathuranga B. Ranaweera |
| author_facet | Sachini J. Udari Sayoka Shamodhi Rumesh M. Nelumdeniya Udayana Ranatunga Nimesha N. Senadeera Chathuranga B. Ranaweera |
| author_sort | Sachini J. Udari |
| collection | DOAJ |
| description | The Clp/Hsp100 family, part of the ATPase associated with various cellular activities (AAA+) superfamily, includes caseinolytic peptidase B (ClpB), a highly conserved protein found in bacteria, fungi, protozoa, and plants. Notably, ClpB is present in all ESKAPE pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. ClpB plays a crucial role in reactivating and disaggregating proteins, enabling pathogens to survive under host-induced stress and conferring thermotolerance to bacterial cells. Infections caused by ESKAPE pathogens are particularly challenging due to their resistance to broad-spectrum antibiotics and biofilm formation, posing a significant global health threat as they are often multidrug-resistant, extensively drug-resistant, and pan-drug-resistant. Given its absence in human cells and its essential role in bacterial survival under stress, ClpB is a promising target for antimicrobial therapy. Targeting Hsp100 family proteins could lead to the development of novel antifungal and antiprotozoal treatments. This review explores the function of ClpB in the survival of ESKAPE pathogens and the protozoan Plasmodium falciparum. Relevant research findings were compiled using academic databases, and data analysis was performed using Clustal Omega Multiple Sequence Alignment and Boxshade tools. |
| format | Article |
| id | doaj-art-81d217a216c94285b393009a1fc628b1 |
| institution | Kabale University |
| issn | 2221-1691 2588-9222 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj-art-81d217a216c94285b393009a1fc628b12025-02-06T04:54:51ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912588-92222025-01-0115111010.4103/apjtb.apjtb_590_24ClpB chaperone as a promising target for antimicrobial therapy: A narrative reviewSachini J. UdariSayoka ShamodhiRumesh M. NelumdeniyaUdayana RanatungaNimesha N. SenadeeraChathuranga B. RanaweeraThe Clp/Hsp100 family, part of the ATPase associated with various cellular activities (AAA+) superfamily, includes caseinolytic peptidase B (ClpB), a highly conserved protein found in bacteria, fungi, protozoa, and plants. Notably, ClpB is present in all ESKAPE pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. ClpB plays a crucial role in reactivating and disaggregating proteins, enabling pathogens to survive under host-induced stress and conferring thermotolerance to bacterial cells. Infections caused by ESKAPE pathogens are particularly challenging due to their resistance to broad-spectrum antibiotics and biofilm formation, posing a significant global health threat as they are often multidrug-resistant, extensively drug-resistant, and pan-drug-resistant. Given its absence in human cells and its essential role in bacterial survival under stress, ClpB is a promising target for antimicrobial therapy. Targeting Hsp100 family proteins could lead to the development of novel antifungal and antiprotozoal treatments. This review explores the function of ClpB in the survival of ESKAPE pathogens and the protozoan Plasmodium falciparum. Relevant research findings were compiled using academic databases, and data analysis was performed using Clustal Omega Multiple Sequence Alignment and Boxshade tools.https://journals.lww.com/10.4103/apjtb.apjtb_590_24molecular chaperoneclpbeskape pathogensthermotoleranceheat shock proteinsplasmodium falciparum |
| spellingShingle | Sachini J. Udari Sayoka Shamodhi Rumesh M. Nelumdeniya Udayana Ranatunga Nimesha N. Senadeera Chathuranga B. Ranaweera ClpB chaperone as a promising target for antimicrobial therapy: A narrative review Asian Pacific Journal of Tropical Biomedicine molecular chaperone clpb eskape pathogens thermotolerance heat shock proteins plasmodium falciparum |
| title | ClpB chaperone as a promising target for antimicrobial therapy: A narrative review |
| title_full | ClpB chaperone as a promising target for antimicrobial therapy: A narrative review |
| title_fullStr | ClpB chaperone as a promising target for antimicrobial therapy: A narrative review |
| title_full_unstemmed | ClpB chaperone as a promising target for antimicrobial therapy: A narrative review |
| title_short | ClpB chaperone as a promising target for antimicrobial therapy: A narrative review |
| title_sort | clpb chaperone as a promising target for antimicrobial therapy a narrative review |
| topic | molecular chaperone clpb eskape pathogens thermotolerance heat shock proteins plasmodium falciparum |
| url | https://journals.lww.com/10.4103/apjtb.apjtb_590_24 |
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