Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group
Introduction. Drooling in Parkinson’s disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling in a PD cohort and compare it with a control group. Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of...
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2023-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2023/3104425 |
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| author | Diego Santos-García Teresa de Deus Fonticoba Carlos Cores Bartolomé Maria J. Feal Painceiras Maria Cristina Íñiguez-Alvarado Silvia Jesús Maria Teresa Buongiorno Lluís Planellas Marina Cosgaya Juan García Caldentey Nuria Caballol Ines Legarda Jorge Hernández Vara Iria Cabo Lydia López Manzanares Isabel González Aramburu Maria A. Ávila Rivera Víctor Gómez Mayordomo Víctor Nogueira Víctor Puente Julio Dotor García-Soto Carmen Borrué Berta Solano Vila María Álvarez Sauco Lydia Vela Sonia Escalante Esther Cubo Francisco Carrillo Padilla Juan C. Martínez Castrillo Pilar Sánchez Alonso Maria G. Alonso Losada Nuria López Ariztegui Itziar Gastón Jaime Kulisevsky Marta Blázquez Estrada Manuel Seijo Javier Rúiz Martínez Caridad Valero Mónica Kurtis Oriol de Fábregues Jessica González Ardura Ruben Alonso Redondo Carlos Ordás Luis M. L. López Díaz Darrian McAfee Pablo Martinez-Martin Pablo Mir Study Group COPPADIS |
| author_facet | Diego Santos-García Teresa de Deus Fonticoba Carlos Cores Bartolomé Maria J. Feal Painceiras Maria Cristina Íñiguez-Alvarado Silvia Jesús Maria Teresa Buongiorno Lluís Planellas Marina Cosgaya Juan García Caldentey Nuria Caballol Ines Legarda Jorge Hernández Vara Iria Cabo Lydia López Manzanares Isabel González Aramburu Maria A. Ávila Rivera Víctor Gómez Mayordomo Víctor Nogueira Víctor Puente Julio Dotor García-Soto Carmen Borrué Berta Solano Vila María Álvarez Sauco Lydia Vela Sonia Escalante Esther Cubo Francisco Carrillo Padilla Juan C. Martínez Castrillo Pilar Sánchez Alonso Maria G. Alonso Losada Nuria López Ariztegui Itziar Gastón Jaime Kulisevsky Marta Blázquez Estrada Manuel Seijo Javier Rúiz Martínez Caridad Valero Mónica Kurtis Oriol de Fábregues Jessica González Ardura Ruben Alonso Redondo Carlos Ordás Luis M. L. López Díaz Darrian McAfee Pablo Martinez-Martin Pablo Mir Study Group COPPADIS |
| author_sort | Diego Santos-García |
| collection | DOAJ |
| description | Introduction. Drooling in Parkinson’s disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling in a PD cohort and compare it with a control group. Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of very early PD patients. Patients and Methods. PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30-day follow-up (V2) from 35 centers in Spain from the COPPADIS cohort were included in this longitudinal prospective study. Subjects were classified as with or without drooling according to item 19 of the NMSS (Nonmotor Symptoms Scale) at V0, V1 (1-year ± 15 days), and V2 for patients and at V0 and V2 for controls. Results. The frequency of drooling in PD patients was 40.1% (277/691) at V0 (2.4% (5/201) in controls; p < 0.0001), 43.7% (264/604) at V1, and 48.2% (242/502) at V2 (3.2% (4/124) in controls; p < 0.0001), with a period prevalence of 63.6% (306/481). Being older (OR = 1.032; p = 0.012), being male (OR = 2.333; p < 0.0001), having greater nonmotor symptom (NMS) burden at the baseline (NMSS total score at V0; OR = 1.020; p < 0.0001), and having a greater increase in the NMS burden from V0 to V2 (change in the NMSS total score from V0 to V2; OR = 1.012; p < 0.0001) were identified as independent predictors of drooling after the 2-year follow-up. Similar results were observed in the group of patients with ≤2 years since symptom onset, with a cumulative prevalence of 64.6% and a higher score on the UPDRS-III at V0 (OR = 1.121; p = 0.007) as a predictor of drooling at V2. Conclusion. Drooling is frequent in PD patients even at the initial onset of the disease and is associated with a greater motor severity and NMS burden. |
| format | Article |
| id | doaj-art-81cf020ff63443259403ed892b65e659 |
| institution | Kabale University |
| issn | 2042-0080 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-81cf020ff63443259403ed892b65e6592025-02-03T06:42:51ZengWileyParkinson's Disease2042-00802023-01-01202310.1155/2023/3104425Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control GroupDiego Santos-García0Teresa de Deus Fonticoba1Carlos Cores Bartolomé2Maria J. Feal Painceiras3Maria Cristina Íñiguez-Alvarado4Silvia Jesús5Maria Teresa Buongiorno6Lluís Planellas7Marina Cosgaya8Juan García Caldentey9Nuria Caballol10Ines Legarda11Jorge Hernández Vara12Iria Cabo13Lydia López Manzanares14Isabel González Aramburu15Maria A. Ávila Rivera16Víctor Gómez Mayordomo17Víctor Nogueira18Víctor Puente19Julio Dotor García-Soto20Carmen Borrué21Berta Solano Vila22María Álvarez Sauco23Lydia Vela24Sonia Escalante25Esther Cubo26Francisco Carrillo Padilla27Juan C. Martínez Castrillo28Pilar Sánchez Alonso29Maria G. Alonso Losada30Nuria López Ariztegui31Itziar Gastón32Jaime Kulisevsky33Marta Blázquez Estrada34Manuel Seijo35Javier Rúiz Martínez36Caridad Valero37Mónica Kurtis38Oriol de Fábregues39Jessica González Ardura40Ruben Alonso Redondo41Carlos Ordás42Luis M. L. López Díaz43Darrian McAfee44Pablo Martinez-Martin45Pablo Mir46Study Group COPPADIS47CHUAC,Complejo Hospitalario Universitario de A CoruñaCHUF,Complejo Hospitalario Universitario de FerrolCHUAC,Complejo Hospitalario Universitario de A CoruñaCHUAC,Complejo Hospitalario Universitario de A CoruñaCHUAC,Complejo Hospitalario Universitario de A CoruñaUnidad de Trastornos del MovimientoHospital Universitari Mutua de TerrassaClínica del PilarHospital Clínic de BarcelonaCentro Neurológico Oms 42Consorci Sanitari IntegralHospital Universitario Son EspasesHospital Universitario Vall d’HebronComplejo Hospitalario Universitario de Pontevedra (CHOP)Hospital Universitario La PrincesaHospital Universitario Marqués de ValdecillaConsorci Sanitari IntegralHospital Universitario Clínico San CarlosHospital Da CostaHospital del MarHospital Universitario Virgen MacarenaHospital Infanta SofíaInstitut d’Assistència Sanitària (IAS)Hospital General Universitario de ElcheFundación Hospital de AlcorcónHospital de Tortosa Verge de La Cinta (HTVC)Complejo Asistencial Universitario de BurgosHospital Universitario de CanariasHospital Universitario Ramón y CajalHospital Universitario Puerta de HierroHospital Álvaro CunqueiroComplejo Hospitalario de ToledoComplejo Hospitalario de NavarraHospital de Sant PauHospital Universitario Central de AsturiasComplejo Hospitalario Universitario de Pontevedra (CHOP)Hospital Universitario DonostiaHospital Arnau de VilanovaHospital Ruber InternacionalHospital Universitario Vall d’HebronHospital de CabueñesUniversitario Lucus Augusti (HULA)Hospital Rey Juan CarlosComplejo Hospitalario Universitario de Orense (CHUO)University of Maryland School of MedicineCIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas)Unidad de Trastornos del MovimientoFundación DegenIntroduction. Drooling in Parkinson’s disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling in a PD cohort and compare it with a control group. Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of very early PD patients. Patients and Methods. PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30-day follow-up (V2) from 35 centers in Spain from the COPPADIS cohort were included in this longitudinal prospective study. Subjects were classified as with or without drooling according to item 19 of the NMSS (Nonmotor Symptoms Scale) at V0, V1 (1-year ± 15 days), and V2 for patients and at V0 and V2 for controls. Results. The frequency of drooling in PD patients was 40.1% (277/691) at V0 (2.4% (5/201) in controls; p < 0.0001), 43.7% (264/604) at V1, and 48.2% (242/502) at V2 (3.2% (4/124) in controls; p < 0.0001), with a period prevalence of 63.6% (306/481). Being older (OR = 1.032; p = 0.012), being male (OR = 2.333; p < 0.0001), having greater nonmotor symptom (NMS) burden at the baseline (NMSS total score at V0; OR = 1.020; p < 0.0001), and having a greater increase in the NMS burden from V0 to V2 (change in the NMSS total score from V0 to V2; OR = 1.012; p < 0.0001) were identified as independent predictors of drooling after the 2-year follow-up. Similar results were observed in the group of patients with ≤2 years since symptom onset, with a cumulative prevalence of 64.6% and a higher score on the UPDRS-III at V0 (OR = 1.121; p = 0.007) as a predictor of drooling at V2. Conclusion. Drooling is frequent in PD patients even at the initial onset of the disease and is associated with a greater motor severity and NMS burden.http://dx.doi.org/10.1155/2023/3104425 |
| spellingShingle | Diego Santos-García Teresa de Deus Fonticoba Carlos Cores Bartolomé Maria J. Feal Painceiras Maria Cristina Íñiguez-Alvarado Silvia Jesús Maria Teresa Buongiorno Lluís Planellas Marina Cosgaya Juan García Caldentey Nuria Caballol Ines Legarda Jorge Hernández Vara Iria Cabo Lydia López Manzanares Isabel González Aramburu Maria A. Ávila Rivera Víctor Gómez Mayordomo Víctor Nogueira Víctor Puente Julio Dotor García-Soto Carmen Borrué Berta Solano Vila María Álvarez Sauco Lydia Vela Sonia Escalante Esther Cubo Francisco Carrillo Padilla Juan C. Martínez Castrillo Pilar Sánchez Alonso Maria G. Alonso Losada Nuria López Ariztegui Itziar Gastón Jaime Kulisevsky Marta Blázquez Estrada Manuel Seijo Javier Rúiz Martínez Caridad Valero Mónica Kurtis Oriol de Fábregues Jessica González Ardura Ruben Alonso Redondo Carlos Ordás Luis M. L. López Díaz Darrian McAfee Pablo Martinez-Martin Pablo Mir Study Group COPPADIS Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group Parkinson's Disease |
| title | Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group |
| title_full | Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group |
| title_fullStr | Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group |
| title_full_unstemmed | Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group |
| title_short | Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group |
| title_sort | prevalence and factors associated with drooling in parkinson s disease results from a longitudinal prospective cohort and comparison with a control group |
| url | http://dx.doi.org/10.1155/2023/3104425 |
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