Synthesis of Silver-Doxycycline Complex Nanoparticles and Their Biological Evaluation on MCF-7 Cell Line of the Breast Cancer
In the current study, we aim to evaluate the effect of the combination of silver and doxycycline (silver-doxycycline complex) on the viability of the MCF-7 cell line of the breast in comparison with each of them. The Ag-doxycycline NPs were synthesized using silver nitrate and doxycycline solutions....
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2021/9944214 |
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| author | Vahid Mohammadkarimi Negar Azarpira Zahra Ghanbarinasab Pezhman Shiri Fatemeh Sadat Dehghani Amin Nakhostin-Ansari Fatemeh Tayyebi-Khorrami Amir Atapour Ali Mohammad Amani |
| author_facet | Vahid Mohammadkarimi Negar Azarpira Zahra Ghanbarinasab Pezhman Shiri Fatemeh Sadat Dehghani Amin Nakhostin-Ansari Fatemeh Tayyebi-Khorrami Amir Atapour Ali Mohammad Amani |
| author_sort | Vahid Mohammadkarimi |
| collection | DOAJ |
| description | In the current study, we aim to evaluate the effect of the combination of silver and doxycycline (silver-doxycycline complex) on the viability of the MCF-7 cell line of the breast in comparison with each of them. The Ag-doxycycline NPs were synthesized using silver nitrate and doxycycline solutions. The synthesized Ag-doxycycline NPs were characterized with several analyses. Ag-doxycycline NPs with a concentration of 25 μM is significantly more effective in decreasing the viability of MCF-7 cells than Ag with the same concentration (P<0.05). Doxycycline with a concentration of 6.25 μM also has a more potent effect on the viability of MCF-7 cells than Ag with the same concentration (P<0.05). Ag-doxycycline NPs with a 25 μM concentration is more effective than the concentration of 3.125 μM (P<0.05). Ag-doxycycline NPs were found to be more effective than AgNPs alone in inhibiting the growth of the MCF-7 cells. Also, the increasing utility of nanotechnology in multiple aspects of medicine can lead to using this technology in the treatment of different types of cancer in the future. |
| format | Article |
| id | doaj-art-81be55acc47547b2b30eaae8aa6a1b58 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-81be55acc47547b2b30eaae8aa6a1b582025-02-03T05:43:46ZengWileyJournal of Chemistry2090-90632090-90712021-01-01202110.1155/2021/99442149944214Synthesis of Silver-Doxycycline Complex Nanoparticles and Their Biological Evaluation on MCF-7 Cell Line of the Breast CancerVahid Mohammadkarimi0Negar Azarpira1Zahra Ghanbarinasab2Pezhman Shiri3Fatemeh Sadat Dehghani4Amin Nakhostin-Ansari5Fatemeh Tayyebi-Khorrami6Amir Atapour7Ali Mohammad Amani8Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pathology, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranSports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranIn the current study, we aim to evaluate the effect of the combination of silver and doxycycline (silver-doxycycline complex) on the viability of the MCF-7 cell line of the breast in comparison with each of them. The Ag-doxycycline NPs were synthesized using silver nitrate and doxycycline solutions. The synthesized Ag-doxycycline NPs were characterized with several analyses. Ag-doxycycline NPs with a concentration of 25 μM is significantly more effective in decreasing the viability of MCF-7 cells than Ag with the same concentration (P<0.05). Doxycycline with a concentration of 6.25 μM also has a more potent effect on the viability of MCF-7 cells than Ag with the same concentration (P<0.05). Ag-doxycycline NPs with a 25 μM concentration is more effective than the concentration of 3.125 μM (P<0.05). Ag-doxycycline NPs were found to be more effective than AgNPs alone in inhibiting the growth of the MCF-7 cells. Also, the increasing utility of nanotechnology in multiple aspects of medicine can lead to using this technology in the treatment of different types of cancer in the future.http://dx.doi.org/10.1155/2021/9944214 |
| spellingShingle | Vahid Mohammadkarimi Negar Azarpira Zahra Ghanbarinasab Pezhman Shiri Fatemeh Sadat Dehghani Amin Nakhostin-Ansari Fatemeh Tayyebi-Khorrami Amir Atapour Ali Mohammad Amani Synthesis of Silver-Doxycycline Complex Nanoparticles and Their Biological Evaluation on MCF-7 Cell Line of the Breast Cancer Journal of Chemistry |
| title | Synthesis of Silver-Doxycycline Complex Nanoparticles and Their Biological Evaluation on MCF-7 Cell Line of the Breast Cancer |
| title_full | Synthesis of Silver-Doxycycline Complex Nanoparticles and Their Biological Evaluation on MCF-7 Cell Line of the Breast Cancer |
| title_fullStr | Synthesis of Silver-Doxycycline Complex Nanoparticles and Their Biological Evaluation on MCF-7 Cell Line of the Breast Cancer |
| title_full_unstemmed | Synthesis of Silver-Doxycycline Complex Nanoparticles and Their Biological Evaluation on MCF-7 Cell Line of the Breast Cancer |
| title_short | Synthesis of Silver-Doxycycline Complex Nanoparticles and Their Biological Evaluation on MCF-7 Cell Line of the Breast Cancer |
| title_sort | synthesis of silver doxycycline complex nanoparticles and their biological evaluation on mcf 7 cell line of the breast cancer |
| url | http://dx.doi.org/10.1155/2021/9944214 |
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