Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles
Strategy to synthesize novel carbazole, that is, 2,3-dihydro-2-phenyl-6H-pyridazino[4, 5-b]carbazole-1,4-dione (2), is developed as key reaction. This novel compound showed ideal reactivity toward different functional groups like methyl, carboxylic, nitro, piperazine, and amine; thus series of its d...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/818739 |
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| author | Ghazala Yaqub Abdul Hannan Erum Akbar Muhammad Usman Almas Hamid Zubi Sadiq Mehwish Iqbal |
| author_facet | Ghazala Yaqub Abdul Hannan Erum Akbar Muhammad Usman Almas Hamid Zubi Sadiq Mehwish Iqbal |
| author_sort | Ghazala Yaqub |
| collection | DOAJ |
| description | Strategy to synthesize novel carbazole, that is, 2,3-dihydro-2-phenyl-6H-pyridazino[4, 5-b]carbazole-1,4-dione (2), is developed as key reaction. This novel compound showed ideal reactivity toward different functional groups like methyl, carboxylic, nitro, piperazine, and amine; thus series of its derivatives are synthesized sequentially with the aim to fuel up the carbazole compounds with new versatile derivatives. All compounds were investigated for their activity against bacteria (MRSA and S. typhi) and fungi (Candida albicans). Among tested compounds 3, 6, and 8 exhibited pronounced antibacterial activities while 2, 5, and 9 also showed moderate activities. 2, 3, 5, 7, and 9 showed stronger antifungal activity against Candida albicans comparable to positive control. |
| format | Article |
| id | doaj-art-81b8ea65952541f8a872b74b3d11380c |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-81b8ea65952541f8a872b74b3d11380c2025-02-03T01:29:55ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/818739818739Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino CarbazolesGhazala Yaqub0Abdul Hannan1Erum Akbar2Muhammad Usman3Almas Hamid4Zubi Sadiq5Mehwish Iqbal6Department of Environmental Sciences, Kinnaird College for Women, Lahore 54000, PakistanDepartment of Microbiology, University of Health Sciences, Lahore 54000, PakistanDepartment of Chemistry, Lahore College for Women University, Lahore 54000, PakistanDepartment of Microbiology, University of Health Sciences, Lahore 54000, PakistanDepartment of Environmental Sciences, Kinnaird College for Women, Lahore 54000, PakistanDepartment of Chemistry (Girls), College of Science, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Chemistry, Lahore College for Women University, Lahore 54000, PakistanStrategy to synthesize novel carbazole, that is, 2,3-dihydro-2-phenyl-6H-pyridazino[4, 5-b]carbazole-1,4-dione (2), is developed as key reaction. This novel compound showed ideal reactivity toward different functional groups like methyl, carboxylic, nitro, piperazine, and amine; thus series of its derivatives are synthesized sequentially with the aim to fuel up the carbazole compounds with new versatile derivatives. All compounds were investigated for their activity against bacteria (MRSA and S. typhi) and fungi (Candida albicans). Among tested compounds 3, 6, and 8 exhibited pronounced antibacterial activities while 2, 5, and 9 also showed moderate activities. 2, 3, 5, 7, and 9 showed stronger antifungal activity against Candida albicans comparable to positive control.http://dx.doi.org/10.1155/2013/818739 |
| spellingShingle | Ghazala Yaqub Abdul Hannan Erum Akbar Muhammad Usman Almas Hamid Zubi Sadiq Mehwish Iqbal Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles Journal of Chemistry |
| title | Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles |
| title_full | Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles |
| title_fullStr | Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles |
| title_full_unstemmed | Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles |
| title_short | Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles |
| title_sort | synthesis antibacterial and antifungal activities of novel pyridazino carbazoles |
| url | http://dx.doi.org/10.1155/2013/818739 |
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