Invalid Self-Assessment of Olfactory Functioning in Parkinson’s Disease Patients May Mislead the Neurologist
Olfactory dysfunction (OD) is a prominent nonmotor symptom in Parkinson’s disease (PD), and OD is a supportive diagnostic criterion for PD. Physicians often ask their patients if they have noticed a smell disorder. This study evaluates the diagnostic validity of OD self-assessment in PD. To this end...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2020/7548394 |
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| _version_ | 1832568508629647360 |
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| author | Nele Schmidt Laura Paschen Karsten Witt |
| author_facet | Nele Schmidt Laura Paschen Karsten Witt |
| author_sort | Nele Schmidt |
| collection | DOAJ |
| description | Olfactory dysfunction (OD) is a prominent nonmotor symptom in Parkinson’s disease (PD), and OD is a supportive diagnostic criterion for PD. Physicians often ask their patients if they have noticed a smell disorder. This study evaluates the diagnostic validity of OD self-assessment in PD. To this end, 64 PD patients and 33 age-matched healthy controls were enrolled in a study assessing subjective and objective olfactory functioning. To examine subjective olfactory abilities, first, patients and controls had to classify their olfactory sense as “impaired” or “unimpaired,” comparable to a realistic situation in an outpatient setting. Second, to evaluate subjective olfactory acuity, a visual analogue scale (VAS) was used. Third, the Sniffin’ Sticks test battery was used as an objective instrument to diagnose OD. Categorical olfactory self-assessment predicts the classification normosmic versus hyposmic based on the global Sniffin’ Sticks score (TDI) with a sensitivity of 0.79 and a specificity of 0.45. TDI correlated significantly with the VAS (r = 0.297, p=0.017). The ROC curve analysis, using the VAS rating as a predictor for objective olfaction, revealed 42 as the best possible cutoff score with an area under the curve of 0.63. These results demonstrate that olfactory self-assessments show a low accuracy and are not suitable for the diagnosis of a smell disorder in PD. Objective measures are necessary to evaluate olfactory sense in clinical and research settings. |
| format | Article |
| id | doaj-art-81b61c2292b7468a9d20b57814e2bc73 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-81b61c2292b7468a9d20b57814e2bc732025-02-03T00:58:52ZengWileyParkinson's Disease2090-80832042-00802020-01-01202010.1155/2020/75483947548394Invalid Self-Assessment of Olfactory Functioning in Parkinson’s Disease Patients May Mislead the NeurologistNele Schmidt0Laura Paschen1Karsten Witt2Department of Neurology, University Oldenburg, Steinweg 13–17, Oldenburg 26122, GermanyDepartment of Neurology, University Medical Center Schleswig-Holstein, Arnold-Heller-Street 3, Kiel 24105, GermanyDepartment of Neurology, University Oldenburg, Steinweg 13–17, Oldenburg 26122, GermanyOlfactory dysfunction (OD) is a prominent nonmotor symptom in Parkinson’s disease (PD), and OD is a supportive diagnostic criterion for PD. Physicians often ask their patients if they have noticed a smell disorder. This study evaluates the diagnostic validity of OD self-assessment in PD. To this end, 64 PD patients and 33 age-matched healthy controls were enrolled in a study assessing subjective and objective olfactory functioning. To examine subjective olfactory abilities, first, patients and controls had to classify their olfactory sense as “impaired” or “unimpaired,” comparable to a realistic situation in an outpatient setting. Second, to evaluate subjective olfactory acuity, a visual analogue scale (VAS) was used. Third, the Sniffin’ Sticks test battery was used as an objective instrument to diagnose OD. Categorical olfactory self-assessment predicts the classification normosmic versus hyposmic based on the global Sniffin’ Sticks score (TDI) with a sensitivity of 0.79 and a specificity of 0.45. TDI correlated significantly with the VAS (r = 0.297, p=0.017). The ROC curve analysis, using the VAS rating as a predictor for objective olfaction, revealed 42 as the best possible cutoff score with an area under the curve of 0.63. These results demonstrate that olfactory self-assessments show a low accuracy and are not suitable for the diagnosis of a smell disorder in PD. Objective measures are necessary to evaluate olfactory sense in clinical and research settings.http://dx.doi.org/10.1155/2020/7548394 |
| spellingShingle | Nele Schmidt Laura Paschen Karsten Witt Invalid Self-Assessment of Olfactory Functioning in Parkinson’s Disease Patients May Mislead the Neurologist Parkinson's Disease |
| title | Invalid Self-Assessment of Olfactory Functioning in Parkinson’s Disease Patients May Mislead the Neurologist |
| title_full | Invalid Self-Assessment of Olfactory Functioning in Parkinson’s Disease Patients May Mislead the Neurologist |
| title_fullStr | Invalid Self-Assessment of Olfactory Functioning in Parkinson’s Disease Patients May Mislead the Neurologist |
| title_full_unstemmed | Invalid Self-Assessment of Olfactory Functioning in Parkinson’s Disease Patients May Mislead the Neurologist |
| title_short | Invalid Self-Assessment of Olfactory Functioning in Parkinson’s Disease Patients May Mislead the Neurologist |
| title_sort | invalid self assessment of olfactory functioning in parkinson s disease patients may mislead the neurologist |
| url | http://dx.doi.org/10.1155/2020/7548394 |
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