Assessment of Salivary Neutrophil Gelatinase-Associated Lipocalin Levels in Diseased and Healthy Periodontium
Background: periodontal disease is one of the most frequent human diseases. Depending on the severity of the inflammation, the destructive process may affect both the gingiva (gingivitis) and/or the periodontal ligament and alveolar bone that surround and support the teeth (periodontitis). Ob...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Baghdad/ Al-Kindy College of Medicine
2024-12-01
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| Series: | مجله كليه طب الكندي |
| Subjects: | |
| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/956 |
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| Summary: | Background: periodontal disease is one of the most frequent human diseases. Depending on the severity of the inflammation, the destructive process may affect both the gingiva (gingivitis) and/or the periodontal ligament and alveolar bone that surround and support the teeth (periodontitis).
Objective: The study aimed to determine and compare the level of salivary Neutrophil gelatinase-associated lipocalin in periodontal health and disease (gingivitis and periodontitis stage I-III).
Subjects and Methods: A total of 90 individuals participated in the research separated into five groups, clinically healthy (n=10), gingivitis (n=20), stage I periodontitis (n=20), stage II periodontitis (n=20) and stage III periodontitis (n=20), periodontal parameters were recorded, and the level of salivary Neutrophil gelatinase-associated lipocalin was assessed by using the enzyme-linked immunosorbent assay.
Results: Neutrophil gelatinase-associated lipocalin salivary level was significantly higher (p<0.05) in periodontal disease groups compared to healthy controls. A statistically significant difference was also found between gingivitis and advanced periodontitis (stageII-III) (p<0.05). No significant difference (p>0.05) was found between different stages of periodontitis.
Conclusions: Neutrophil gelatinase-associated lipocalin is associated with periodontal diseases and my play a role in its pathogenesis
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| ISSN: | 1810-9543 2521-4365 |