Mood instability and risk of gastrointestinal diseases - a univariable and multivariable mendelian randomization study
Abstract Background Mood instability, characterized by sudden and unpredictable mood shifts, is prevalent in psychiatric disorders and as a personality trait. Its association with gastrointestinal diseases has been recognized but remains poorly understood in terms of causality. Methods This study ai...
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2024-12-01
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| Series: | Annals of General Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12991-024-00537-7 |
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| author | Rui-lin Liu Qing-chun Song Li-ming Liu Yi-feng Yang Wei-hong Zhu |
| author_facet | Rui-lin Liu Qing-chun Song Li-ming Liu Yi-feng Yang Wei-hong Zhu |
| author_sort | Rui-lin Liu |
| collection | DOAJ |
| description | Abstract Background Mood instability, characterized by sudden and unpredictable mood shifts, is prevalent in psychiatric disorders and as a personality trait. Its association with gastrointestinal diseases has been recognized but remains poorly understood in terms of causality. Methods This study aims to investigate the causal relationship between mood instability and a spectrum of gastrointestinal diseases by univariable and multivariable mendelian randomization analysis. The exposure and outcome data were retrieved from the IEU open GWAS database, the UK biobank and the FinnGen study. Instrumental variables were selected to meet relevance, independence, and exclusion restriction criteria. GWAS datasets for mood instability and 28 gastrointestinal diseases were utilized, incorporating diverse populations and genders. Univariable and multivariable Mendelian randomization analyses were conducted using R software. MR statistics from different datasets for the same disease were meta-analyzed to maximize the study population. Results In univariable MR analysis, genetic predisposition to mood instability showed significant associations with increased risk for several gastrointestinal diseases, including: gastroesophageal reflux disease, gastric ulcer, acute gastritis, irritable bowel syndrome, internal hemorrhoids, cirrhosis, cholecystitis, cholelithiasis, acute pancreatitis, chronic pancreatitis. In multivariable MR analysis, after adjusting for major depression, bipolar disorder, anxiety disorder, and schizophrenia, associations with the following gastrointestinal diseases remained statistically significant: internal hemorrhoids, cirrhosis, acute pancreatitis, chronic pancreatitis. Conclusion This study provides compelling evidence for a potential causal relationship between mood instability and certain gastrointestinal diseases underscoring the importance of considering mood instability as a potential risk factor for gastrointestinal diseases as well as the positive role of maintaining mood stability in the prevention of gastrointestinal disorders. |
| format | Article |
| id | doaj-art-81b1f14b36b34ed88a4b02d98e4865c4 |
| institution | OA Journals |
| issn | 1744-859X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
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| series | Annals of General Psychiatry |
| spelling | doaj-art-81b1f14b36b34ed88a4b02d98e4865c42025-08-20T02:31:50ZengBMCAnnals of General Psychiatry1744-859X2024-12-0123111210.1186/s12991-024-00537-7Mood instability and risk of gastrointestinal diseases - a univariable and multivariable mendelian randomization studyRui-lin Liu0Qing-chun Song1Li-ming Liu2Yi-feng Yang3Wei-hong Zhu4Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Central South UniversityDepartment of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Central South UniversityDepartment of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Central South UniversityDepartment of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Central South UniversityDepartment of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Central South UniversityAbstract Background Mood instability, characterized by sudden and unpredictable mood shifts, is prevalent in psychiatric disorders and as a personality trait. Its association with gastrointestinal diseases has been recognized but remains poorly understood in terms of causality. Methods This study aims to investigate the causal relationship between mood instability and a spectrum of gastrointestinal diseases by univariable and multivariable mendelian randomization analysis. The exposure and outcome data were retrieved from the IEU open GWAS database, the UK biobank and the FinnGen study. Instrumental variables were selected to meet relevance, independence, and exclusion restriction criteria. GWAS datasets for mood instability and 28 gastrointestinal diseases were utilized, incorporating diverse populations and genders. Univariable and multivariable Mendelian randomization analyses were conducted using R software. MR statistics from different datasets for the same disease were meta-analyzed to maximize the study population. Results In univariable MR analysis, genetic predisposition to mood instability showed significant associations with increased risk for several gastrointestinal diseases, including: gastroesophageal reflux disease, gastric ulcer, acute gastritis, irritable bowel syndrome, internal hemorrhoids, cirrhosis, cholecystitis, cholelithiasis, acute pancreatitis, chronic pancreatitis. In multivariable MR analysis, after adjusting for major depression, bipolar disorder, anxiety disorder, and schizophrenia, associations with the following gastrointestinal diseases remained statistically significant: internal hemorrhoids, cirrhosis, acute pancreatitis, chronic pancreatitis. Conclusion This study provides compelling evidence for a potential causal relationship between mood instability and certain gastrointestinal diseases underscoring the importance of considering mood instability as a potential risk factor for gastrointestinal diseases as well as the positive role of maintaining mood stability in the prevention of gastrointestinal disorders.https://doi.org/10.1186/s12991-024-00537-7Mood instabilityGastrointestinal diseaseMendelian randomization |
| spellingShingle | Rui-lin Liu Qing-chun Song Li-ming Liu Yi-feng Yang Wei-hong Zhu Mood instability and risk of gastrointestinal diseases - a univariable and multivariable mendelian randomization study Annals of General Psychiatry Mood instability Gastrointestinal disease Mendelian randomization |
| title | Mood instability and risk of gastrointestinal diseases - a univariable and multivariable mendelian randomization study |
| title_full | Mood instability and risk of gastrointestinal diseases - a univariable and multivariable mendelian randomization study |
| title_fullStr | Mood instability and risk of gastrointestinal diseases - a univariable and multivariable mendelian randomization study |
| title_full_unstemmed | Mood instability and risk of gastrointestinal diseases - a univariable and multivariable mendelian randomization study |
| title_short | Mood instability and risk of gastrointestinal diseases - a univariable and multivariable mendelian randomization study |
| title_sort | mood instability and risk of gastrointestinal diseases a univariable and multivariable mendelian randomization study |
| topic | Mood instability Gastrointestinal disease Mendelian randomization |
| url | https://doi.org/10.1186/s12991-024-00537-7 |
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