Cyclooxygenase-2 expression in cervical cancer
Background/Aim. Cyclooxygenase (COX) or prostaglandin H2 synthase is the first enzyme that catalyzes the first two steps in the biosynthesis of prostaglandins from arachidonic acid. The aim of the study was to determine the expression level of COX-2 in patients with cervical cancer and comp...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2014-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501411997M.pdf |
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| Summary: | Background/Aim. Cyclooxygenase (COX) or prostaglandin H2 synthase is the
first enzyme that catalyzes the first two steps in the biosynthesis of
prostaglandins from arachidonic acid. The aim of the study was to determine
the expression level of COX-2 in patients with cervical cancer and compare it
with that in the control group with no cervical pathology. Methods. The study
included 76 patients divided into two groups: the control group - 30 patients
without histopathological changes and the group A - 46 patients with cervical
cancer, FIGO stage IB-IIA. Histopathological and immunohistochemical analyses
were performed in these two groups of patients. Results. In the control
group, the expression of COX-2 was not confirmed compared to the group A of
26 (56.52%) patients. The expression of COX-2 showed a statistically
significant difference in the presence of lymphocytic stromal infiltration (p
= 0.0053). The expression of COX-2 was more pronounced in the stromal tissue
without lymphocytic infiltration (80% vs 20%). Conclusion. A higher
expression of COX-2 in cervical carcinoma without stromal lymphocytic
infiltration suggests a possible paradoxical effect of COX-2 in
immunosuppression. Frequent COX- 2 expression in the subgroup with poor
prognostic histological parameters in the group A indicates the importance of
COX-2 expression in the carcinogenesis of cervical cancer. |
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| ISSN: | 0042-8450 |